Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells

Janet Dyson, Frank Le Foll, Pierre Magal, Ahmed Noussair, Jennifer Pasquier

Research output: Contribution to journalArticle

Abstract

The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results.

LanguageEnglish
Pages239-253
Number of pages15
JournalJournal of Theoretical Biology
Volume461
DOIs
Publication statusPublished - 14 Jan 2019

Fingerprint

Glycoproteins
Glycoprotein
P-Glycoprotein
Breast Cancer
breast neoplasms
Cells
Breast Neoplasms
Proteins
Cell
Protein
cells
Theoretical Models
proteins
multiple drug resistance
Drug Resistance
Mathematical models
Multiple Drug Resistance
Mathematical Analysis
mathematical models
Numerical Scheme

Keywords

  • Indirect transfers
  • Kinetic
  • Population dynamics models
  • Quasi-linear equation

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells. / Dyson, Janet; Foll, Frank Le; Magal, Pierre; Noussair, Ahmed; Pasquier, Jennifer.

In: Journal of Theoretical Biology, Vol. 461, 14.01.2019, p. 239-253.

Research output: Contribution to journalArticle

Dyson, Janet ; Foll, Frank Le ; Magal, Pierre ; Noussair, Ahmed ; Pasquier, Jennifer. / Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells. In: Journal of Theoretical Biology. 2019 ; Vol. 461. pp. 239-253.
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