Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells

Janet Dyson, Frank Le Foll, Pierre Magal, Ahmed Noussair, Jennifer Pasquier

Research output: Contribution to journalArticle

Abstract

The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results.

Original languageEnglish
Pages (from-to)239-253
Number of pages15
JournalJournal of Theoretical Biology
Volume461
DOIs
Publication statusPublished - 14 Jan 2019

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Keywords

  • Indirect transfers
  • Kinetic
  • Population dynamics models
  • Quasi-linear equation

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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