Diffuse fibrotic lung disease: a correlative study

J. D. Fulmer, W. C. Roberts, Ronald Crystal

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Diffuse fibrotic lung disease is a complex, clinically protean disorder. The authors have undertaken a large scale, multidisciplinary study of the etiology, pathogenesis, pathophysiology, and therapy of this disorder. This paper presents correlative clinical, physiologic, and pathologic data in a selected group of patients with diffuse fibrotic lung disease. The data suggest the following: obstructive disease of airways with increased resistance to air flow is present in a significant percentage of patients with diffuse fibrotic lung disease; although the peak transpulmonary pressure correlated with the degree of fibrosis, the lack of correlation of other parameters of the volume pressure curve with the histopathology casts doubt on the usefulness of the volume pressure relationships as a longterm monitor of diffuse fibrotic disease; exercise physiologic testing with quantitation of the rate of change in PaO2 with oxygen consumption appears to be the most sensitive correlate to clinical severity of disease; the dead space to tidal volume ratio during exercise correlates poorly with evidence of pulmonary vascular disease, but appears to correlate well with evidence of obstruction of airways. The value of this test in the diagnosis of pulmonary vascular disease must be interpreted in light of co existing abnormalities of distribution of ventilation.

Original languageEnglish
Pages (from-to)263-265
Number of pages3
JournalChest
Volume69
Issue number2 .sup.
Publication statusPublished - 1 Dec 1976
Externally publishedYes

Fingerprint

Lung Diseases
Vascular Diseases
Pressure
Exercise
Tidal Volume
Airway Obstruction
Oxygen Consumption
Ventilation
Fibrosis
Air
Therapeutics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Fulmer, J. D., Roberts, W. C., & Crystal, R. (1976). Diffuse fibrotic lung disease: a correlative study. Chest, 69(2 .sup.), 263-265.

Diffuse fibrotic lung disease : a correlative study. / Fulmer, J. D.; Roberts, W. C.; Crystal, Ronald.

In: Chest, Vol. 69, No. 2 .sup., 01.12.1976, p. 263-265.

Research output: Contribution to journalArticle

Fulmer, JD, Roberts, WC & Crystal, R 1976, 'Diffuse fibrotic lung disease: a correlative study', Chest, vol. 69, no. 2 .sup., pp. 263-265.
Fulmer JD, Roberts WC, Crystal R. Diffuse fibrotic lung disease: a correlative study. Chest. 1976 Dec 1;69(2 .sup.):263-265.
Fulmer, J. D. ; Roberts, W. C. ; Crystal, Ronald. / Diffuse fibrotic lung disease : a correlative study. In: Chest. 1976 ; Vol. 69, No. 2 .sup. pp. 263-265.
@article{d6d2ffa39f4547baa0fcb9cad9add0db,
title = "Diffuse fibrotic lung disease: a correlative study",
abstract = "Diffuse fibrotic lung disease is a complex, clinically protean disorder. The authors have undertaken a large scale, multidisciplinary study of the etiology, pathogenesis, pathophysiology, and therapy of this disorder. This paper presents correlative clinical, physiologic, and pathologic data in a selected group of patients with diffuse fibrotic lung disease. The data suggest the following: obstructive disease of airways with increased resistance to air flow is present in a significant percentage of patients with diffuse fibrotic lung disease; although the peak transpulmonary pressure correlated with the degree of fibrosis, the lack of correlation of other parameters of the volume pressure curve with the histopathology casts doubt on the usefulness of the volume pressure relationships as a longterm monitor of diffuse fibrotic disease; exercise physiologic testing with quantitation of the rate of change in PaO2 with oxygen consumption appears to be the most sensitive correlate to clinical severity of disease; the dead space to tidal volume ratio during exercise correlates poorly with evidence of pulmonary vascular disease, but appears to correlate well with evidence of obstruction of airways. The value of this test in the diagnosis of pulmonary vascular disease must be interpreted in light of co existing abnormalities of distribution of ventilation.",
author = "Fulmer, {J. D.} and Roberts, {W. C.} and Ronald Crystal",
year = "1976",
month = "12",
day = "1",
language = "English",
volume = "69",
pages = "263--265",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "2 .sup.",

}

TY - JOUR

T1 - Diffuse fibrotic lung disease

T2 - a correlative study

AU - Fulmer, J. D.

AU - Roberts, W. C.

AU - Crystal, Ronald

PY - 1976/12/1

Y1 - 1976/12/1

N2 - Diffuse fibrotic lung disease is a complex, clinically protean disorder. The authors have undertaken a large scale, multidisciplinary study of the etiology, pathogenesis, pathophysiology, and therapy of this disorder. This paper presents correlative clinical, physiologic, and pathologic data in a selected group of patients with diffuse fibrotic lung disease. The data suggest the following: obstructive disease of airways with increased resistance to air flow is present in a significant percentage of patients with diffuse fibrotic lung disease; although the peak transpulmonary pressure correlated with the degree of fibrosis, the lack of correlation of other parameters of the volume pressure curve with the histopathology casts doubt on the usefulness of the volume pressure relationships as a longterm monitor of diffuse fibrotic disease; exercise physiologic testing with quantitation of the rate of change in PaO2 with oxygen consumption appears to be the most sensitive correlate to clinical severity of disease; the dead space to tidal volume ratio during exercise correlates poorly with evidence of pulmonary vascular disease, but appears to correlate well with evidence of obstruction of airways. The value of this test in the diagnosis of pulmonary vascular disease must be interpreted in light of co existing abnormalities of distribution of ventilation.

AB - Diffuse fibrotic lung disease is a complex, clinically protean disorder. The authors have undertaken a large scale, multidisciplinary study of the etiology, pathogenesis, pathophysiology, and therapy of this disorder. This paper presents correlative clinical, physiologic, and pathologic data in a selected group of patients with diffuse fibrotic lung disease. The data suggest the following: obstructive disease of airways with increased resistance to air flow is present in a significant percentage of patients with diffuse fibrotic lung disease; although the peak transpulmonary pressure correlated with the degree of fibrosis, the lack of correlation of other parameters of the volume pressure curve with the histopathology casts doubt on the usefulness of the volume pressure relationships as a longterm monitor of diffuse fibrotic disease; exercise physiologic testing with quantitation of the rate of change in PaO2 with oxygen consumption appears to be the most sensitive correlate to clinical severity of disease; the dead space to tidal volume ratio during exercise correlates poorly with evidence of pulmonary vascular disease, but appears to correlate well with evidence of obstruction of airways. The value of this test in the diagnosis of pulmonary vascular disease must be interpreted in light of co existing abnormalities of distribution of ventilation.

UR - http://www.scopus.com/inward/record.url?scp=0017258458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017258458&partnerID=8YFLogxK

M3 - Article

C2 - 1248300

AN - SCOPUS:0017258458

VL - 69

SP - 263

EP - 265

JO - Chest

JF - Chest

SN - 0012-3692

IS - 2 .sup.

ER -