Differentially expressed circulating microRNAs in the development of acute diabetic Charcot foot

Jennifer Pasquier, Vimal Ramachandran, Moh'D Rasheed Abu-Qaoud, Binitha Thomas, Manasi J. Benurwar, Omar Chidiac, Jessica Hoarau, Amal Robay, Khalid Adnan Mohamed A. Fakhro, Robert A. Menzies, Amin Jayyousi, Mahmoud Zirie, Jassim Al Suwaidi, Rayaz Malik, Talal K. Talal, Hani Najafi, Arash Rafii Tabrizi, Charbel Abi Khalil

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Abstract

Aim: Charcot foot (CF) is a rare complication of Type 2 diabetes (T2D). Materials & methods: We assessed circulating miRNAs in 17 patients with T2D and acute CF (G1), 17 patients with T2D (G2) and equivalent neuropathy and 17 patients with T2D without neuropathy (G3) using the high-throughput miRNA expression profiling. Results: 51 significantly deregulated miRNAs were identified in G1 versus G2, 37 in G1 versus G3 and 64 in G2 versus G3. Furthermore, we demonstrated that 16 miRNAs differentially expressed between G1 versus G2 could be involved in osteoclastic differentiation. Among them, eight are key factors involved in CF pathophysiology. Conclusion: Our data reveal that CF patients exhibit an altered expression profile of circulating miRNA.

Original languageEnglish
Pages (from-to)1267-1278
Number of pages12
JournalEpigenomics
Volume10
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

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Keywords

  • Charcot foot
  • diabetes
  • epigenetics
  • inflammation
  • micro-RNA

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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