Differential sensitivity of Dahl salt-sensitive and Dahl salt-resistant rats the hypotensive action of acute nifedipine administration

J. N. Sharma, P. G. Fernandez, I. Laher, Christopher Triggle

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Abstract

The calcium antagonist, nifedipine, was intravenously administered in a cumulative fashion, from 0.5 to 12 mg/kg, to Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats which had been maintained on a high (8.0%) or low (0.4%) salt (NaCl) diet. We observed, compared with the DR rats, dose-related and significant (P < 0.001) falls in the systolic (SBP) (72 ± 3 and 60 ± 9%, respectively) and diatolic blood pressure (DBP) (67 ± 2 and 62 ± 6%) of the DS rats maintained either on the low (0.4%) or high (8.0%) salt diets. In contrast, nifedipine therapy comparatively produced only moderate changes in the SBP and DBP of the DR rats (36 ± 12, 27 ± 9, 31 ± 10, and 30 ± 11%, respectively). We hypothesize that this differential sensitivity of the DS and DR rats to the hypotensive action of nifedipine may reflect a significantly more important role for a high resting Ca2+ influx, through nifedipine sensitive channels, in the maintenance of the blood pressure of the DS rat.

Original languageEnglish
Pages (from-to)241-243
Number of pages3
JournalCanadian Journal of Physiology and Pharmacology
Volume62
Issue number2
Publication statusPublished - 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Pharmacology
  • Physiology (medical)

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