Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses

Elizabeth Forbes, Nicholas J. Van Panhuys, Booki Min, Graham Le Gros

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Improved analytical tools have revealed that the development and expression of a Th2 immune response can be broken down into distinct stages with respect to the cytokine microenvironment that is required. Although IL-4 and its STAT6-signalling pathway are critical for the expression of Th2 effector immune responses in peripheral tissues such as the skin, lung and gut, IL-4 and STAT6 signalling are not required for the initial generation of IL-4-producing Th2 cells in the lymph node. This finding reveals that we have yet to identify the key cytokine or microenvironment that stimulates the development of this most intriguing CD4 T-helper subset and emphasises the tissue specificity and timing of IL-4/STAT6-dependent Th2 effector responses.

Original languageEnglish
Pages (from-to)240-243
Number of pages4
JournalImmunology and Cell Biology
Volume88
Issue number3
DOIs
Publication statusPublished - Mar 2010
Externally publishedYes

Fingerprint

Interleukin-4
T-Lymphocytes
Cytokines
Th2 Cells
Organ Specificity
Critical Pathways
Lymph Nodes
Lung
Skin

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses. / Forbes, Elizabeth; Van Panhuys, Nicholas J.; Min, Booki; Le Gros, Graham.

In: Immunology and Cell Biology, Vol. 88, No. 3, 03.2010, p. 240-243.

Research output: Contribution to journalReview article

@article{6e8c727a7b8e44b79d93710e95269288,
title = "Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses",
abstract = "Improved analytical tools have revealed that the development and expression of a Th2 immune response can be broken down into distinct stages with respect to the cytokine microenvironment that is required. Although IL-4 and its STAT6-signalling pathway are critical for the expression of Th2 effector immune responses in peripheral tissues such as the skin, lung and gut, IL-4 and STAT6 signalling are not required for the initial generation of IL-4-producing Th2 cells in the lymph node. This finding reveals that we have yet to identify the key cytokine or microenvironment that stimulates the development of this most intriguing CD4 T-helper subset and emphasises the tissue specificity and timing of IL-4/STAT6-dependent Th2 effector responses.",
author = "Elizabeth Forbes and {Van Panhuys}, {Nicholas J.} and Booki Min and {Le Gros}, Graham",
year = "2010",
month = "3",
doi = "10.1038/icb.2009.101",
language = "English",
volume = "88",
pages = "240--243",
journal = "Immunology and Cell Biology",
issn = "0818-9641",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses

AU - Forbes, Elizabeth

AU - Van Panhuys, Nicholas J.

AU - Min, Booki

AU - Le Gros, Graham

PY - 2010/3

Y1 - 2010/3

N2 - Improved analytical tools have revealed that the development and expression of a Th2 immune response can be broken down into distinct stages with respect to the cytokine microenvironment that is required. Although IL-4 and its STAT6-signalling pathway are critical for the expression of Th2 effector immune responses in peripheral tissues such as the skin, lung and gut, IL-4 and STAT6 signalling are not required for the initial generation of IL-4-producing Th2 cells in the lymph node. This finding reveals that we have yet to identify the key cytokine or microenvironment that stimulates the development of this most intriguing CD4 T-helper subset and emphasises the tissue specificity and timing of IL-4/STAT6-dependent Th2 effector responses.

AB - Improved analytical tools have revealed that the development and expression of a Th2 immune response can be broken down into distinct stages with respect to the cytokine microenvironment that is required. Although IL-4 and its STAT6-signalling pathway are critical for the expression of Th2 effector immune responses in peripheral tissues such as the skin, lung and gut, IL-4 and STAT6 signalling are not required for the initial generation of IL-4-producing Th2 cells in the lymph node. This finding reveals that we have yet to identify the key cytokine or microenvironment that stimulates the development of this most intriguing CD4 T-helper subset and emphasises the tissue specificity and timing of IL-4/STAT6-dependent Th2 effector responses.

UR - http://www.scopus.com/inward/record.url?scp=77949876184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949876184&partnerID=8YFLogxK

U2 - 10.1038/icb.2009.101

DO - 10.1038/icb.2009.101

M3 - Review article

VL - 88

SP - 240

EP - 243

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

SN - 0818-9641

IS - 3

ER -