Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses

Elizabeth Forbes, Nicholas J. Van Panhuys, Booki Min, Graham Le Gros

Research output: Contribution to journalReview article

25 Citations (Scopus)


Improved analytical tools have revealed that the development and expression of a Th2 immune response can be broken down into distinct stages with respect to the cytokine microenvironment that is required. Although IL-4 and its STAT6-signalling pathway are critical for the expression of Th2 effector immune responses in peripheral tissues such as the skin, lung and gut, IL-4 and STAT6 signalling are not required for the initial generation of IL-4-producing Th2 cells in the lymph node. This finding reveals that we have yet to identify the key cytokine or microenvironment that stimulates the development of this most intriguing CD4 T-helper subset and emphasises the tissue specificity and timing of IL-4/STAT6-dependent Th2 effector responses.

Original languageEnglish
Pages (from-to)240-243
Number of pages4
JournalImmunology and Cell Biology
Issue number3
Publication statusPublished - Mar 2010
Externally publishedYes


ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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