Different plasma ionized calcium correlations with blood pressure in high and low renin normotensive adults in utah

Steven C. Hunt, Roger R. Williams, Hiroshi Kuida

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12 Citations (Scopus)


Plasma ionized calcium levels have been shown to be lower than normotensive control levels in hy­pertensive patients with low plasma renin activity and higher than control levels in hypertensive pa­tients with high renin activity; they did not differ between high and low plasma renin activity groups of normotensive controls. To see if ionized calcium may have different relationships with blood pres­sure across renin categories in normotensive indi­viduals, plasma ionized calcium was measured on 875 healthy individuals, ages 3 to 83, who had never been diagnosed as having hypertension. Blood pressures were measured in the sitting, standing, and supine positions, along with pressures mea­sured during two stress maneuvers: Isometric hand­grip and a 50° tilt from a supine position. There was no linear correlation of blood pressure with plasma ionized calcium in the entire sample of youths or adults. However, after dividing the adults into ter- tiles based on plasma renin activity, there were sig­nificant inverse correlations between ionized cal­cium and systolic and diastolic blood pressure in the low renin group (r = -0.16 to -0.25, P <.05), while the systolic blood pressure correlations were signifi­cantly positive in the high renin group (r = 0.14 to 0.22, P <.05). Adults with normal renin levels did not have any significant correlations of plasma ionized calcium with blood pressure. These con­founding effects of renin were greater for systolic than for diastolic blood pressure. These correlations within renin tertiles occurred even though there were no differences in mean blood pressure, plasma ionized calcium, total plasma protein and plasma sodium across renin categories. Youths did not show any consistent blood pressure correlations with cal­cium across the renin categories. We conclude that, in normotensive adults, the relationship of plasma ionized calcium to blood pressure partially depends on plasma renin activity, and that intervention measures such as calcium supplementation de­signed to prevent future hypertension in high risk individuals may need to be tailored to the renin status of the normotensive person to ensure that blood pressure remains normal rather than being made worse.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalAmerican journal of hypertension
Issue number1
Publication statusPublished - Apr 1991



  • Blood pressure
  • Calcium
  • Plasma renin activity
  • Sodium

ASJC Scopus subject areas

  • Internal Medicine

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