Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries

Bing Jian Feng, Majida Jalbout, Wided Ben Ayoub, Meriem Khyatti, Sami Dahmoul, Messaoud Ayad, Fatima Maachi, Wided Bedadra, Meriem Abdoun, Sarah Mesli, Mokhtar Hamdi-Cherif, Kada Boualga, Noureddine Bouaouina, Lotfi Chouchane, Abdellatif Benider, Farhat Ben Ayed, David Goldgar, Marilys Corbex

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63 Citations (Scopus)

Abstract

North Africa is one of the major Nasopharyngeal Carcinoma (NPC) endemic regions. Specific food items unique to this area were implicated to be associated with NPC risk, but results were inconsistent. Here we have performed a large-scale case-control study in the Maghrebian population from Tunisia, Algeria and Morocco. From 2002 to 2005, interviews were conducted on 636 cases and 615 controls. Controls were hospitalized individuals from 15 non-cancer hospital departments, or friends and family members of non-NPC cancer subjects, matched by center, childhood household type (rural or urban), age and sex. Conditional logistic regression is used to evaluate the risk of factors. In results, consumption of rancid butter, rancid sheep fat and preserved meat not spicy (mainly quaddid) were associated with significantly increased risk of NPC, while consumption of cooked vegetables and industrial preserved fish was associated with reduced risk. Other foods such as fresh citrus fruits and spicy preserved meat (mainly osban) in childhood, industrial made olive condiments in adulthood, were marginally associated. In multivariate analyses, only rancid butter, rancid sheep fat and cooked vegetables were significantly associated with NPC. In regard to possible causative substances, our results implicate the involvement of butyric acid, a potential Epstein-Barr virus (EBV) activator.

Original languageEnglish
Pages (from-to)1550-1555
Number of pages6
JournalInternational Journal of Cancer
Volume121
Issue number7
DOIs
Publication statusPublished - 1 Oct 2007

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Keywords

  • Algeria
  • Diet
  • Morocco
  • Nasopharyngeal carcinoma
  • Tunisia

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Feng, B. J., Jalbout, M., Ayoub, W. B., Khyatti, M., Dahmoul, S., Ayad, M., Maachi, F., Bedadra, W., Abdoun, M., Mesli, S., Hamdi-Cherif, M., Boualga, K., Bouaouina, N., Chouchane, L., Benider, A., Ayed, F. B., Goldgar, D., & Corbex, M. (2007). Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries. International Journal of Cancer, 121(7), 1550-1555. https://doi.org/10.1002/ijc.22813