Dietary phytochemicals targeting cancer stem cells

Alena Liskova, Peter Kubatka, Marek Samec, Pavol Zubor, Milos Mlyncek, Tibor Bielik, Samson Mathews Samuel, Anthony Zulli, Taeg Kyu Kwon, Dietrich Busselberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research.

Original languageEnglish
Article number899
JournalMolecules
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Neoplastic Stem Cells
stem cells
Phytochemicals
Stem cells
cancer
Neoplasms
Vegetables
Nutrition
Fruits
Research
Fruit
diets
vegetables
Cells
fruits
Health
Apoptosis
Neoplasm Metastasis
Diet
apoptosis

Keywords

  • Cancer stem cells
  • Cell signaling
  • Fruit
  • Phytochemicals
  • Plant-derived foods
  • Vegetable

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Liskova, A., Kubatka, P., Samec, M., Zubor, P., Mlyncek, M., Bielik, T., ... Busselberg, D. (2019). Dietary phytochemicals targeting cancer stem cells. Molecules, [899]. https://doi.org/10.3390/molecules24050899

Dietary phytochemicals targeting cancer stem cells. / Liskova, Alena; Kubatka, Peter; Samec, Marek; Zubor, Pavol; Mlyncek, Milos; Bielik, Tibor; Mathews Samuel, Samson; Zulli, Anthony; Kwon, Taeg Kyu; Busselberg, Dietrich.

In: Molecules, 01.01.2019.

Research output: Contribution to journalArticle

Liskova, A, Kubatka, P, Samec, M, Zubor, P, Mlyncek, M, Bielik, T, Mathews Samuel, S, Zulli, A, Kwon, TK & Busselberg, D 2019, 'Dietary phytochemicals targeting cancer stem cells', Molecules. https://doi.org/10.3390/molecules24050899
Liskova A, Kubatka P, Samec M, Zubor P, Mlyncek M, Bielik T et al. Dietary phytochemicals targeting cancer stem cells. Molecules. 2019 Jan 1. 899. https://doi.org/10.3390/molecules24050899
Liskova, Alena ; Kubatka, Peter ; Samec, Marek ; Zubor, Pavol ; Mlyncek, Milos ; Bielik, Tibor ; Mathews Samuel, Samson ; Zulli, Anthony ; Kwon, Taeg Kyu ; Busselberg, Dietrich. / Dietary phytochemicals targeting cancer stem cells. In: Molecules. 2019.
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