Diabetic neuropathy: A focus on small fibres

Research output: Contribution to journalArticle

Abstract

Diabetic peripheral neuropathy (DPN) is diagnosed too late, which contrasts with our approach for diabetic retinopathy and nephropathy, where incipient disease is detected early enabling timely treatment. The 10-g monofilament and a foot exam are the commonly used methods for screening diabetic neuropathy, but this primarily identifies moderate to severe diabetic neuropathy. Small fibres are damaged early and are associated with the development of painful diabetic neuropathy, foot ulceration, and Charcot foot. Tests of small fibre damage include thermal thresholds, microneurography, evoked potentials, sudomotor function, laser Doppler flare, skin biopsy, and corneal confocal microscopy. Measures of small fibre damage and repair may be key to the assessment of efficacy in clinical trials of disease modifying therapies for diabetic neuropathy.

Original languageEnglish
Article numbere3255
JournalDiabetes/Metabolism Research and Reviews
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Fingerprint

Diabetic Neuropathies
Foot
Diabetic Foot
Diabetic Nephropathies
Peripheral Nervous System Diseases
Diabetic Retinopathy
Evoked Potentials
Confocal Microscopy
Lasers
Hot Temperature
Clinical Trials
Biopsy
Skin

Keywords

  • corneal confocal microscopy
  • diabetes
  • diagnosis
  • neuropathy
  • skin biopsy
  • small fibres
  • sudomotor

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Diabetic neuropathy : A focus on small fibres. / Malik, Rayaz A.

In: Diabetes/Metabolism Research and Reviews, 01.01.2019.

Research output: Contribution to journalArticle

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