Diabetic gastroparesis: Therapeutic options

Uazman Alam, Omar Asghar, Rayaz Malik

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Gastroparesis is a condition characterized by delayed gastric emptying and the most common known underlying cause is diabetes mellitus. Symptoms include nausea, vomiting, abdominal fullness, and early satiety, which impact to varying degrees on the patient's quality of life. Symptoms and deficits do not necessarily relate to each other, hence despite significant abnormalities in gastric emptying, some individuals have only minimal symptoms and, conversely, severe symptoms do not always relate to measures of gastric emptying. Prokinetic agents such as metoclopramide, domperidone, and erythromycin enhance gastric motility and have remained the mainstay of treatment for several decades, despite unwanted side effects and numerous drug interactions. Mechanical therapies such as endoscopic pyloric botulinum toxin injection, gastric electrical stimulation, and gastrostomy or jejunostomy are used in intractable diabetic gastroparesis (DG), refractory to prokinetic therapies. Mitemcinal and TZP-101 are novel investigational motilin receptor and ghrelin agonists, respectively, and show promise in the treatment of DG. The aim of this review is to provide an update on prokinetic and mechanical therapies in the treatment of DG.

Original languageEnglish
Pages (from-to)32-43
Number of pages12
JournalDiabetes Therapy
Volume1
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

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Keywords

  • diabetic gastroparesis
  • gastric electrical stimulation
  • ghrelin
  • mechanical therapy
  • prokinetic therapy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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