Diabetes Dyslipidemia

Jonathan D. Schofield, Yifen Liu, Prasanna Rao-Balakrishna, Rayaz Malik, Handrean Soran

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

Diabetes mellitus is associated with a considerably increased risk of premature atherosclerotic cardiovascular disease. Intensive glycemic control has essentially failed to significantly improve cardiovascular outcomes in clinical trials. Dyslipidemia is common in diabetes and there is strong evidence that cholesterol lowering improves cardiovascular outcomes, even in patients with apparently unremarkable lipid profiles. Here, the authors review the pathophysiology and implications of the alterations in lipoproteins observed in both type 1 and type 2 diabetes, the effect of medications commonly used in the management of diabetes on the lipid profile, the evidence for lifestyle and pharmaceutical interventions, and national and international recommendations for the management of dyslipidemia in patients with diabetes.

Original languageEnglish
Pages (from-to)203-219
Number of pages17
JournalDiabetes Therapy
Volume7
Issue number2
DOIs
Publication statusPublished - 1 Jun 2016

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Keywords

  • Cardiovascular risk
  • Diabetes
  • Dyslipidemia
  • Lipoproteins
  • Low density lipoprotein cholesterol

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Schofield, J. D., Liu, Y., Rao-Balakrishna, P., Malik, R., & Soran, H. (2016). Diabetes Dyslipidemia. Diabetes Therapy, 7(2), 203-219. https://doi.org/10.1007/s13300-016-0167-x