Developmental regulation of elastin synthesis

Jeffrey M. Davidson, Shigeki Shibahara, Kent Smith, Ronald Crystal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The regulation of elastin production has been evaluated and compared in two systems in the developing sheep: nuchal ligament and lung. Absolute rates of production in explant culture were estimated by immunoprecipitation of newly synthesized elastin and determination of precursor pool specific activities. Lung elastin production increased about 2.5-fold while nuchal ligament production increased about 9-fold during the latter half of gestation. In comparison, the activities of elastin messenger RNA(mRNAE) of these tissues were determined in a cell-free system by immunoprecipitation. The increases in mRNAE activity largely paralleled the rises in elastin production, suggesting that elastin synthesis in these tissues is regulated, at least in part, by the availability of translationally active mRNAE.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalConnective Tissue Research
Volume8
Issue number3-4
DOIs
Publication statusPublished - 1 Jan 1981
Externally publishedYes

Fingerprint

Elastin
Ligaments
Immunoprecipitation
Tissue
Nuchal Translucency Measurement
Lung
Cell-Free System
Sheep
Availability
Pregnancy
Messenger RNA

ASJC Scopus subject areas

  • Rheumatology
  • Biochemistry
  • Orthopedics and Sports Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Developmental regulation of elastin synthesis. / Davidson, Jeffrey M.; Shibahara, Shigeki; Smith, Kent; Crystal, Ronald.

In: Connective Tissue Research, Vol. 8, No. 3-4, 01.01.1981, p. 209-212.

Research output: Contribution to journalArticle

Davidson, Jeffrey M. ; Shibahara, Shigeki ; Smith, Kent ; Crystal, Ronald. / Developmental regulation of elastin synthesis. In: Connective Tissue Research. 1981 ; Vol. 8, No. 3-4. pp. 209-212.
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