Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease

Balpreet Matharu, Omar Ali El-Agnaf, Amna Razvi, Brian M. Austen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a devastating degenerative disorder of the brain for which there is no cure or effective treatment. There is much evidence to suggest that β-amyloid protein (Aβ) aggregation in the brain leading to deposits is an important step in the development of AD. Recently, two peptides, RGKLVFFGR (OR1) and RGKLVFFGR-NH2 (OR2) containing the sequence KLVFF, which is the central region (residues 16-20) of Aβ, have been found to be potent inhibitors of Aβ aggregate formation. Here we report that retro-inversion of these sequences increases efficacy of the peptides in the inhibition of aggregation and toxicity of β-amyloid. We describe the synthesis and inhibitory properties of these retro-inverso peptides.

Original languageEnglish
Pages (from-to)1866-1872
Number of pages7
JournalPeptides
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

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Keywords

  • β-Amyloid
  • Aggregation
  • Alzheimer's disease

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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