Developing a tool for the validation of quantitative DCE-MRI

Karin Bol, Joost C. Haeck, Lejla Alic, Monique Bernsen, Marion De Jong, Wiro J. Niessen, Jifke F. Veenland

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is becoming an indispensable tool to non-invasively study tumor characteristics. However, many different DCE-analysis methods are currently being used. To compare and validate different methods, histology is the gold standard. For this purpose, exact co-localization between histology and MRI images is a prerequisite. In this study a methodology is developed to validate DCE-data with histology with an emphasis on correct registration of DCE-MRI and histological data. A pancreatic tumor was grown in a rat model. The tumor was dissected after MR imaging, embedded in paraffin, and cut into thin slices. These slices were stained with haematoxylin and eosin, digitized and stacked in a 3D volume. Next, the 3D histology was registered to exvivo SWI-weighted MR images, which in turn were registered to in-vivo SWI and DCE images to achieve correct colocalization. Semi-quantitative and quantitative parameters were calculated. Preliminary results suggest that both pharmacokinetic and heuristic DCE-parameters can discriminate between vital and non-vital tumor regions. The developed method offers the basis for an accurate spatial correlation between DCE-MRI derived parametric maps and histology, and facilitates the evaluation of different DCE-MRI analysis methods.

Original languageEnglish
Title of host publicationMedical Imaging 2011
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
DOIs
Publication statusPublished - 16 May 2011
EventMedical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: 13 Feb 201116 Feb 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7965
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period13/2/1116/2/11

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Keywords

  • DCE-MRI
  • DCE-analysis
  • Histology
  • Pharmacokinetic modeling
  • Quantitative
  • Registration
  • Semi-quantitative
  • Two-compartment model

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Bol, K., Haeck, J. C., Alic, L., Bernsen, M., De Jong, M., Niessen, W. J., & Veenland, J. F. (2011). Developing a tool for the validation of quantitative DCE-MRI. In Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging [79651J] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7965). https://doi.org/10.1117/12.877834