Developing a tool for the validation of quantitative DCE-MRI

Karin Bol, Joost C. Haeck, Lejla Alic, Monique Bernsen, Marion De Jong, Wiro J. Niessen, Jifke F. Veenland

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is becoming an indispensable tool to non-invasively study tumor characteristics. However, many different DCE-analysis methods are currently being used. To compare and validate different methods, histology is the gold standard. For this purpose, exact co-localization between histology and MRI images is a prerequisite. In this study a methodology is developed to validate DCE-data with histology with an emphasis on correct registration of DCE-MRI and histological data. A pancreatic tumor was grown in a rat model. The tumor was dissected after MR imaging, embedded in paraffin, and cut into thin slices. These slices were stained with haematoxylin and eosin, digitized and stacked in a 3D volume. Next, the 3D histology was registered to exvivo SWI-weighted MR images, which in turn were registered to in-vivo SWI and DCE images to achieve correct colocalization. Semi-quantitative and quantitative parameters were calculated. Preliminary results suggest that both pharmacokinetic and heuristic DCE-parameters can discriminate between vital and non-vital tumor regions. The developed method offers the basis for an accurate spatial correlation between DCE-MRI derived parametric maps and histology, and facilitates the evaluation of different DCE-MRI analysis methods.

Original languageEnglish
Title of host publicationMedical Imaging 2011
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
Volume7965
DOIs
Publication statusPublished - 16 May 2011
Externally publishedYes
EventMedical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: 13 Feb 201116 Feb 2011

Other

OtherMedical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period13/2/1116/2/11

Fingerprint

Histology
histology
magnetic resonance
Magnetic Resonance Imaging
Tumors
tumors
Neoplasms
Pharmacokinetics
paraffins
Hematoxylin
Eosine Yellowish-(YS)
Paraffin
Magnetic resonance imaging
Paraffins
rats
Rats
methodology
Imaging techniques
evaluation

Keywords

  • DCE-analysis
  • DCE-MRI
  • Histology
  • Pharmacokinetic modeling
  • Quantitative
  • Registration
  • Semi-quantitative
  • Two-compartment model

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Bol, K., Haeck, J. C., Alic, L., Bernsen, M., De Jong, M., Niessen, W. J., & Veenland, J. F. (2011). Developing a tool for the validation of quantitative DCE-MRI. In Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 7965). [79651J] https://doi.org/10.1117/12.877834

Developing a tool for the validation of quantitative DCE-MRI. / Bol, Karin; Haeck, Joost C.; Alic, Lejla; Bernsen, Monique; De Jong, Marion; Niessen, Wiro J.; Veenland, Jifke F.

Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 7965 2011. 79651J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bol, K, Haeck, JC, Alic, L, Bernsen, M, De Jong, M, Niessen, WJ & Veenland, JF 2011, Developing a tool for the validation of quantitative DCE-MRI. in Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging. vol. 7965, 79651J, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, Lake Buena Vista, FL, United States, 13/2/11. https://doi.org/10.1117/12.877834
Bol K, Haeck JC, Alic L, Bernsen M, De Jong M, Niessen WJ et al. Developing a tool for the validation of quantitative DCE-MRI. In Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 7965. 2011. 79651J https://doi.org/10.1117/12.877834
Bol, Karin ; Haeck, Joost C. ; Alic, Lejla ; Bernsen, Monique ; De Jong, Marion ; Niessen, Wiro J. ; Veenland, Jifke F. / Developing a tool for the validation of quantitative DCE-MRI. Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 7965 2011.
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