Determination of trisomy 9p by molecular cytogenetic technology

D. Xiuyuan, D. Sanoudou, Y. Fengtang, C. Hong

Research output: Contribution to journalArticle

Abstract

Objective. To use molecular cytogenetic techniques for the determination of complex chromosomal aberrations that could not be distinguished by conventional cytogenetic method. Methods. Chromosome painting, comparative genomic hybridization (CGH) and color banding chromosome analysis (RxFISH) were used to identify a case with chromosome 9 aberration by G-banding. Results. The patient has a karyotype of 46,XX,9p+ by G-banding. Both chromosomes 9 were uniformly painted, including the extra segment on one of the 9p alleles. CGH revealed a duplication of the entire 9p short arm. After analysis with RxFISH the patient's karyotype could be accurately described as 46,XX,dup9p(p11→p24:: p24→qter). Conclusion. The present report shows that some late technological developments in the field of cytogenetics can facilitate the study of the diseases linked to complex chromosomal aberrations and may find significant application in basic and clinical medical studies.

Original languageEnglish
Pages (from-to)383-385
Number of pages3
JournalChinese Journal of Medical Genetics
Volume16
Issue number6
Publication statusPublished - 28 Dec 1999
Externally publishedYes

Fingerprint

Trisomy
Chromosomes
Cytogenetics
Chromosome Aberrations
Chromosomes, Human, Pair 9
Comparative Genomic Hybridization
Aberrations
Technology
Karyotype
Chromosome Painting
Chromosome Banding
Cytogenetic Analysis
Painting
Color
Alleles

Keywords

  • Chromosomal aberration
  • Chromosome analysis
  • Chromosome painting
  • Color banding
  • Comparative genomic hybridization

ASJC Scopus subject areas

  • Genetics(clinical)
  • Bioengineering

Cite this

Xiuyuan, D., Sanoudou, D., Fengtang, Y., & Hong, C. (1999). Determination of trisomy 9p by molecular cytogenetic technology. Chinese Journal of Medical Genetics, 16(6), 383-385.

Determination of trisomy 9p by molecular cytogenetic technology. / Xiuyuan, D.; Sanoudou, D.; Fengtang, Y.; Hong, C.

In: Chinese Journal of Medical Genetics, Vol. 16, No. 6, 28.12.1999, p. 383-385.

Research output: Contribution to journalArticle

Xiuyuan, D, Sanoudou, D, Fengtang, Y & Hong, C 1999, 'Determination of trisomy 9p by molecular cytogenetic technology', Chinese Journal of Medical Genetics, vol. 16, no. 6, pp. 383-385.
Xiuyuan D, Sanoudou D, Fengtang Y, Hong C. Determination of trisomy 9p by molecular cytogenetic technology. Chinese Journal of Medical Genetics. 1999 Dec 28;16(6):383-385.
Xiuyuan, D. ; Sanoudou, D. ; Fengtang, Y. ; Hong, C. / Determination of trisomy 9p by molecular cytogenetic technology. In: Chinese Journal of Medical Genetics. 1999 ; Vol. 16, No. 6. pp. 383-385.
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