Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

Chris Wai Tung Leung, Feng Guo, Yuning Hong, Engui Zhao, Ryan Tsz Kin Kwok, Nelson Lik Ching Leung, Sijie Chen, Nishant Vaikath, Omar Ali El-Agnaf, Youhong Tang, Wei Ping Gai, Ben Zhong Tang

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Abstract

We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.

Original languageEnglish
Pages (from-to)1866-1869
Number of pages4
JournalChemical Communications
Volume51
Issue number10
DOIs
Publication statusPublished - 4 Feb 2015
Externally publishedYes

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Leung, C. W. T., Guo, F., Hong, Y., Zhao, E., Kwok, R. T. K., Leung, N. L. C., Chen, S., Vaikath, N., Ali El-Agnaf, O., Tang, Y., Gai, W. P., & Tang, B. Z. (2015). Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence. Chemical Communications, 51(10), 1866-1869. https://doi.org/10.1039/c4cc07911f