Deoxynivalenol biomarkers in the urine of UK vegetarians

Liz Wells, Laura Hardie, Courtney Williams, Kay White, Yunru Liu, Barbara De Santis, Francesca Debegnach, Georgio Moretti, Stephanie Greetham, Carlo Brera, Maria Papageorgiou, Natalie J. Thatcher, Alan Rigby, Stephen Atkin, Thozhukat Sathyapalan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Deoxynivalenol (DON) is produced by Fusarium graminearum and is one of the most commonly occurring trichothecenes. Vegetarians are alleged to be a high-risk group for DON exposure due to high intakes of cereals susceptible to the growth of the mycotoxin. This study provides the levels of DON and de-epoxi Deoxynivalenol (DOM-1) in urine analysed by liquid chromatography-mass spectrometry (LC-MS) in UK vegetarians. Over two consecutive days, morning urine samples were collected from 32 vegetarians and 31 UK adult volunteers, and associated food consumption 24 h prior to the sample was recorded. Statistically significant differences between the weight of the UK adults and vegetarians (t = 3.15. df = 61, p ≤ 0.005 two-tailed) were observed. The mean levels of DON in urine for adults on day 1 was 3.05 ng free DON/mg creatinine, and on day 2 was 2.98 ng free DON/mg creatinine. Even though high mean levels were observed, most adults were within the tolerable daily intake. However, for vegetarians, the mean level of urinary DON on day 1 was 6.69 ng free DON/mg creatinine, and on day 2 was 3.42 ng free DON/mg creatinine. These levels equate to up to 32% of vegetarians exceeding recommended tolerable daily intakes (TDI) of exposure (1 µg/kg b.w./day).

Original languageEnglish
Article number196
JournalToxins
Volume9
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Fingerprint

Biomarkers
Urine
Creatinine
No-Observed-Adverse-Effect Level
deoxynivalenol
Vegetarians
Trichothecenes
Recommended Dietary Allowances
Mycotoxins
Liquid chromatography
Fusarium
Liquid Chromatography
Mass spectrometry
Volunteers
Mass Spectrometry
Weights and Measures
Food

Keywords

  • Deoxynivalenol
  • Mycotoxins
  • Vegetarians
  • Vomitoxin

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Wells, L., Hardie, L., Williams, C., White, K., Liu, Y., De Santis, B., ... Sathyapalan, T. (2017). Deoxynivalenol biomarkers in the urine of UK vegetarians. Toxins, 9(7), [196]. https://doi.org/10.3390/toxins9070196

Deoxynivalenol biomarkers in the urine of UK vegetarians. / Wells, Liz; Hardie, Laura; Williams, Courtney; White, Kay; Liu, Yunru; De Santis, Barbara; Debegnach, Francesca; Moretti, Georgio; Greetham, Stephanie; Brera, Carlo; Papageorgiou, Maria; Thatcher, Natalie J.; Rigby, Alan; Atkin, Stephen; Sathyapalan, Thozhukat.

In: Toxins, Vol. 9, No. 7, 196, 01.07.2017.

Research output: Contribution to journalArticle

Wells, L, Hardie, L, Williams, C, White, K, Liu, Y, De Santis, B, Debegnach, F, Moretti, G, Greetham, S, Brera, C, Papageorgiou, M, Thatcher, NJ, Rigby, A, Atkin, S & Sathyapalan, T 2017, 'Deoxynivalenol biomarkers in the urine of UK vegetarians', Toxins, vol. 9, no. 7, 196. https://doi.org/10.3390/toxins9070196
Wells L, Hardie L, Williams C, White K, Liu Y, De Santis B et al. Deoxynivalenol biomarkers in the urine of UK vegetarians. Toxins. 2017 Jul 1;9(7). 196. https://doi.org/10.3390/toxins9070196
Wells, Liz ; Hardie, Laura ; Williams, Courtney ; White, Kay ; Liu, Yunru ; De Santis, Barbara ; Debegnach, Francesca ; Moretti, Georgio ; Greetham, Stephanie ; Brera, Carlo ; Papageorgiou, Maria ; Thatcher, Natalie J. ; Rigby, Alan ; Atkin, Stephen ; Sathyapalan, Thozhukat. / Deoxynivalenol biomarkers in the urine of UK vegetarians. In: Toxins. 2017 ; Vol. 9, No. 7.
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