Democratizing systems immunology with modular transcriptional repertoire analyses

Damien Chaussabel, Nicole Baldwin

Research output: Contribution to journalReview article

89 Citations (Scopus)

Abstract

Individual elements that constitute the immune system have been characterized over the few past decades, mostly through reductionist approaches. The introduction of large-scale profiling platforms has more recently facilitated the assessment of these elements on a global scale. However, the analysis and the interpretation of such large-scale datasets remains a challenge and a barrier for the wider adoption of systems approaches in immunological and clinical studies. In this Innovation article, we describe an analytical strategy that relies on the a priori determination of co-dependent gene sets for a given biological system. Such modular transcriptional repertoires can in turn be used to simplify the analysis and the interpretation of large-scale datasets, and to design targeted immune fingerprinting assays and web applications that will further facilitate the dissemination of systems approaches in immunology.

Original languageEnglish
Pages (from-to)271-280
Number of pages10
JournalNature Reviews Immunology
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 2014

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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