Democratizing systems immunology with modular transcriptional repertoire analyses

Damien Chaussabel, Nicole Baldwin

Research output: Contribution to journalReview article

89 Citations (Scopus)


Individual elements that constitute the immune system have been characterized over the few past decades, mostly through reductionist approaches. The introduction of large-scale profiling platforms has more recently facilitated the assessment of these elements on a global scale. However, the analysis and the interpretation of such large-scale datasets remains a challenge and a barrier for the wider adoption of systems approaches in immunological and clinical studies. In this Innovation article, we describe an analytical strategy that relies on the a priori determination of co-dependent gene sets for a given biological system. Such modular transcriptional repertoires can in turn be used to simplify the analysis and the interpretation of large-scale datasets, and to design targeted immune fingerprinting assays and web applications that will further facilitate the dissemination of systems approaches in immunology.

Original languageEnglish
Pages (from-to)271-280
Number of pages10
JournalNature Reviews Immunology
Issue number4
Publication statusPublished - Apr 2014


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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