Definition of genetic factors in hypertension: A search for major genes. Polygenes, and homogeneous subtypes

Roger R. Williams, Steven Hunt, Sandra J. Hasstedt, Thomas D. Berry, Thomas D. Lily, Gary K. Barlow, Barry M. Stults, Hiroshi Kuida

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Abstract

Essential hypertension is a heterogeneous group of disorders with different causes. This report report reviews approaches taken and results found in current studies of the genetic and environmental determinants of essential hypertension. Recent observations from the University of Utah Cardiovascular Genetics Research Clinic and published data from other studies are cited. Several biochemical tests show strong associations with hypertension and substantial major gene and or poly genie determination including: urinary kallikrein eeretion, intracellular sodium concentration. Sodium-lithium countertransport, plasma haptoglobin phenotypes. MN blood group, and famitial dyslipidemia.

Original languageEnglish
Pages (from-to)S7-S20
JournalJournal of Cardiovascular Pharmacology
Volume12
Issue number3
Publication statusPublished - 1988
Externally publishedYes

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Keywords

  • Biochemistry
  • Coronary heart disease
  • Epidemiology
  • Family history
  • Genetics
  • Hypertension
  • Lipids
  • Pathophysiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Williams, R. R., Hunt, S., Hasstedt, S. J., Berry, T. D., Lily, T. D., Barlow, G. K., Stults, B. M., & Kuida, H. (1988). Definition of genetic factors in hypertension: A search for major genes. Polygenes, and homogeneous subtypes. Journal of Cardiovascular Pharmacology, 12(3), S7-S20.