Defining the role of common variation in the genomic and biological architecture of adult human height

Andrew R. Wood, Tonu Esko, Jian Yang, Sailaja Vedantam, Tune H. Pers, Stefan Gustafsson, Audrey Y. Chu, Karol Estrada, Jian'An Luan, Zoltán Kutalik, Najaf Amin, Martin L. Buchkovich, Damien C. Croteau-Chonka, Felix R. Day, Yanan Duan, Tove Fall, Rudolf Fehrmann, Teresa Ferreira, Anne U. Jackson, Juha Karjalainen & 425 others Ken Sin Lo, Adam E. Locke, Reedik Mägi, Evelin Mihailov, Eleonora Porcu, Joshua C. Randall, André Scherag, Anna A.E. Vinkhuyzen, Harm Jan Westra, Thomas W. Winkler, Tsegaselassie Workalemahu, Jing Hua Zhao, Devin Absher, Eva Albrecht, Denise Anderson, Jeffrey Baron, Marian Beekman, Ayse Demirkan, Georg B. Ehret, Bjarke Feenstra, Mary F. Feitosa, Krista Fischer, Ross M. Fraser, Anuj Goel, Jian Gong, Anne E. Justice, Stavroula Kanoni, Marcus E. Kleber, Kati Kristiansson, Unhee Lim, Vaneet Lotay, Julian C. Lui, Massimo Mangino, Irene Mateo Leach, Carolina Medina-Gomez, Michael A. Nalls, Dale R. Nyholt, Cameron D. Palmer, Dorota Pasko, Sonali Pechlivanis, Inga Prokopenko, Janina S. Ried, Stephan Ripke, Dmitry Shungin, Alena Stancáková, Rona J. Strawbridge, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. Van Der Laan, Jessica Van Setten, Jana V. Van Vliet-Ostaptchouk, Zhaoming Wang, Loïc Yengo, Weihua Zhang, Uzma Afzal, Johan Ärnlöv, Gillian M. Arscott, Stefania Bandinelli, Amy Barrett, Claire Bellis, Amanda J. Bennett, Christian Berne, Matthias Blüher, Jennifer L. Bolton, Yvonne Böttcher, Heather A. Boyd, Marcel Bruinenberg, Brendan M. Buckley, Steven Buyske, Ida H. Caspersen, Peter S. Chines, Robert Clarke, Simone Claudi-Boehm, Matthew Cooper, E. Warwick Daw, Pim A. De Jong, Joris Deelen, Graciela Delgado, Josh C. Denny, Rosalie Dhonukshe-Rutten, Maria Dimitriou, Alex S.F. Doney, Marcus Dörr, Niina Eklund, Elodie Eury, Lasse Folkersen, Melissa E. Garcia, Frank Geller, Vilmantas Giedraitis, Alan S. Go, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Henrik Grönberg, Lisette C.P.G.M. De Groot, Christopher J. Groves, Jeffrey Haessler, Per Hall, Toomas Haller, Goran Hallmans, Anke Hannemann, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Nancy L. Heard-Costa, Quinta Helmer, Gibran Hemani, Anjali K. Henders, Hans L. Hillege, Mark A. Hlatky, Wolfgang Hoffmann, Per Hoffmann, Oddgeir Holmen, Jeanine J. Houwing-Duistermaat, Thomas Illig, Aaron Isaacs, Alan L. James, Janina Jeff, Berit Johansen, Åsa Johansson, Jennifer Jolley, Thorhildur Juliusdottir, Juhani Junttila, Abel N. Kho, Leena Kinnunen, Norman Klopp, Thomas Kocher, Wolfgang Kratzer, Peter Lichtner, Lars Lind, Jaana Lindström, Stéphane Lobbens, Mattias Lorentzon, Yingchang Lu, Valeriya Lyssenko, Patrik K.E. Magnusson, Anubha Mahajan, Marc Maillard, Wendy L. McArdle, Colin A. McKenzie, Stela McLachlan, Paul J. McLaren, Cristina Menni, Sigrun Merger, Lili Milani, Alireza Moayyeri, Keri L. Monda, Mario A. Morken, Gabriele Müller, Martina Müller-Nurasyid, Arthur W. Musk, Narisu Narisu, Matthias Nauck, Ilja M. Nolte, Markus M. Nöthen, Laticia Oozageer, Stefan Pilz, Nigel W. Rayner, Frida Renstrom, Neil R. Robertson, Lynda M. Rose, Ronan Roussel, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Fredrick R. Schumacher, Heribert Schunkert, Robert A. Scott, Joban Sehmi, Thomas Seufferlein, Jianxin Shi, Karri Silventoinen, Johannes H. Smit, Albert Vernon Smith, Joanna Smolonska, Alice V. Stanton, Kathleen Stirrups, David J. Stott, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Ann Christine Syvänen, Bamidele O. Tayo, Gudmar Thorleifsson, Jonathan P. Tyrer, Suzanne Van Dijk, Natasja M. Van Schoor, Nathalie Van Der Velde, Diana Van Heemst, Floor V.A. Van Oort, Sita H. Vermeulen, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Melanie Waldenberger, Roman Wennauer, Lynne R. Wilkens, Christina Willenborg, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Alan F. Wright, Qunyuan Zhang, Dominique Arveiler, Stephan J.L. Bakker, John Beilby, Richard N. Bergman, Sven Bergmann, Reiner Biffar, John Blangero, Dorret I. Boomsma, Stefan R. Bornstein, Pascal Bovet, Paolo Brambilla, Morris J. Brown, Harry Campbell, Mark J. Caulfield, Aravinda Chakravarti, Rory Collins, Francis S. Collins, Dana C. Crawford, L. Adrienne Cupples, John Danesh, Ulf De Faire, Hester M. Den Ruijter, Raimund Erbel, Jeanette Erdmann, Johan G. Eriksson, Martin Farrall, Ele Ferrannini, Jean Ferrières, Ian Ford, Nita G. Forouhi, Terrence Forrester, Ron T. Gansevoort, Pablo V. Gejman, Christian Gieger, Alain Golay, Omri Gottesman, Vilmundur Gudnason, Ulf Gyllensten, David W. Haas, Alistair S. Hall, Tamara B. Harris, Andrew T. Hattersley, Andrew C. Heath, Christian Hengstenberg, Andrew A. Hicks, Lucia A. Hindorff, Aroon D. Hingorani, Albert Hofman, G. Kees Hovingh, Steve E. Humphries, Steven Hunt, Elina Hypponen, Kevin B. Jacobs, Marjo Riitta Jarvelin, Pekka Jousilahti, Antti M. Jula, Jaakko Kaprio, John J.P. Kastelein, Manfred Kayser, Frank Kee, Sirkka M. Keinanen-Kiukaanniemi, Lambertus A. Kiemeney, Jaspal S. Kooner, Charles Kooperberg, Seppo Koskinen, Peter Kovacs, Aldi T. Kraja, Meena Kumari, Johanna Kuusisto, Timo A. Lakka, Claudia Langenberg, Loic Le Marchand, Terho Lehtimäki, Sara Lupoli, Pamela A.F. Madden, Satu Männistö, Paolo Manunta, André Marette, Tara C. Matise, Barbara McKnight, Thomas Meitinger, Frans L. Moll, Grant W. Montgomery, Andrew D. Morris, Andrew P. Morris, Jeffrey C. Murray, Mari Nelis, Claes Ohlsson, Albertine J. Oldehinkel, Ken K. Ong, Willem H. Ouwehand, Gerard Pasterkamp, Annette Peters, Peter P. Pramstaller, Jackie F. Price, Lu Qi, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Treva K. Rice, Marylyn Ritchie, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Jouko Saramies, Mark A. Sarzynski, Peter E.H. Schwarz, Sylvain Sebert, Peter Sever, Alan R. Shuldiner, Juha Sinisalo, Valgerdur Steinthorsdottir, Ronald P. Stolk, Jean Claude Tardif, Anke Tönjes, Angelo Tremblay, Elena Tremoli, Jarmo Virtamo, Marie Claude Vohl, Philippe Amouyel, Folkert W. Asselbergs, Themistocles L. Assimes, Murielle Bochud, Bernhard O. Boehm, Eric Boerwinkle, Erwin P. Bottinger, Claude Bouchard, Stéphane Cauchi, John C. Chambers, Stephen J. Chanock, Richard S. Cooper, Paul I.W. De Bakker, George Dedoussis, Luigi Ferrucci, Paul W. Franks, Philippe Froguel, Leif C. Groop, Christopher A. Haiman, Anders Hamsten, M. Geoffrey Hayes, Jennie Hui, David J. Hunter, Kristian Hveem, J. Wouter Jukema, Robert C. Kaplan, Mika Kivimaki, Diana Kuh, Markku Laakso, Yongmei Liu, Nicholas G. Martin, Winfried März, Mads Melbye, Susanne Moebus, Patricia B. Munroe, Inger Njølstad, Ben A. Oostra, Colin N.A. Palmer, Nancy L. Pedersen, Markus Perola, Louis Pérusse, Ulrike Peters, Joseph E. Powell, Chris Power, Thomas Quertermous, Rainer Rauramaa, Eva Reinmaa, Paul M. Ridker, Fernando Rivadeneira, Jerome I. Rotter, Timo E. Saaristo, Danish Saleheen, David Schlessinger, P. Eline Slagboom, Harold Snieder, Tim D. Spector, Konstantin Strauch, Michael Stumvoll, Jaakko Tuomilehto, Matti Uusitupa, Pim Van Der Harst, Henry Völzke, Mark Walker, Nicholas J. Wareham, Hugh Watkins, H. Erich Wichmann, James F. Wilson, Pieter Zanen, Panos Deloukas, Iris M. Heid, Cecilia M. Lindgren, Karen L. Mohlke, Elizabeth K. Speliotes, Unnur Thorsteinsdottir, Inês Barroso, Caroline S. Fox, Kari E. North, David P. Strachan, Jacques S. Beckmann, Sonja I. Berndt, Michael Boehnke, Ingrid B. Borecki, Mark I. McCarthy, Andres Metspalu, Kari Stefansson, André G. Uitterlinden, Cornelia M. Van Duijn, Lude Franke, Cristen J. Willer, Alkes L. Price, Guillaume Lettre, Ruth J.F. Loos, Michael N. Weedon, Erik Ingelsson, Jeffrey R. O'Connell, Goncalo R. Abecasis, Daniel I. Chasman, Michael E. Goddard, Peter M. Visscher, Joel N. Hirschhorn, Timothy M. Frayling

Research output: Contribution to journalArticle

749 Citations (Scopus)

Abstract

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/I 2-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

Original languageEnglish
Pages (from-to)1173-1186
Number of pages14
JournalNature Genetics
Volume46
Issue number11
DOIs
Publication statusPublished - 5 Nov 2014
Externally publishedYes

Fingerprint

Genes
Genome
Catenins
Fibroblast Growth Factors
Chondroitin Sulfates
Medical Genetics
Hyaluronic Acid
Growth
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Genetics

Cite this

Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., ... Frayling, T. M. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46(11), 1173-1186. https://doi.org/10.1038/ng.3097

Defining the role of common variation in the genomic and biological architecture of adult human height. / Wood, Andrew R.; Esko, Tonu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H.; Gustafsson, Stefan; Chu, Audrey Y.; Estrada, Karol; Luan, Jian'An; Kutalik, Zoltán; Amin, Najaf; Buchkovich, Martin L.; Croteau-Chonka, Damien C.; Day, Felix R.; Duan, Yanan; Fall, Tove; Fehrmann, Rudolf; Ferreira, Teresa; Jackson, Anne U.; Karjalainen, Juha; Lo, Ken Sin; Locke, Adam E.; Mägi, Reedik; Mihailov, Evelin; Porcu, Eleonora; Randall, Joshua C.; Scherag, André; Vinkhuyzen, Anna A.E.; Westra, Harm Jan; Winkler, Thomas W.; Workalemahu, Tsegaselassie; Zhao, Jing Hua; Absher, Devin; Albrecht, Eva; Anderson, Denise; Baron, Jeffrey; Beekman, Marian; Demirkan, Ayse; Ehret, Georg B.; Feenstra, Bjarke; Feitosa, Mary F.; Fischer, Krista; Fraser, Ross M.; Goel, Anuj; Gong, Jian; Justice, Anne E.; Kanoni, Stavroula; Kleber, Marcus E.; Kristiansson, Kati; Lim, Unhee; Lotay, Vaneet; Lui, Julian C.; Mangino, Massimo; Leach, Irene Mateo; Medina-Gomez, Carolina; Nalls, Michael A.; Nyholt, Dale R.; Palmer, Cameron D.; Pasko, Dorota; Pechlivanis, Sonali; Prokopenko, Inga; Ried, Janina S.; Ripke, Stephan; Shungin, Dmitry; Stancáková, Alena; Strawbridge, Rona J.; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; Van Der Laan, Sander W.; Van Setten, Jessica; Van Vliet-Ostaptchouk, Jana V.; Wang, Zhaoming; Yengo, Loïc; Zhang, Weihua; Afzal, Uzma; Ärnlöv, Johan; Arscott, Gillian M.; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J.; Berne, Christian; Blüher, Matthias; Bolton, Jennifer L.; Böttcher, Yvonne; Boyd, Heather A.; Bruinenberg, Marcel; Buckley, Brendan M.; Buyske, Steven; Caspersen, Ida H.; Chines, Peter S.; Clarke, Robert; Claudi-Boehm, Simone; Cooper, Matthew; Daw, E. Warwick; De Jong, Pim A.; Deelen, Joris; Delgado, Graciela; Denny, Josh C.; Dhonukshe-Rutten, Rosalie; Dimitriou, Maria; Doney, Alex S.F.; Dörr, Marcus; Eklund, Niina; Eury, Elodie; Folkersen, Lasse; Garcia, Melissa E.; Geller, Frank; Giedraitis, Vilmantas; Go, Alan S.; Grallert, Harald; Grammer, Tanja B.; Gräßler, Jürgen; Grönberg, Henrik; De Groot, Lisette C.P.G.M.; Groves, Christopher J.; Haessler, Jeffrey; Hall, Per; Haller, Toomas; Hallmans, Goran; Hannemann, Anke; Hartman, Catharina A.; Hassinen, Maija; Hayward, Caroline; Heard-Costa, Nancy L.; Helmer, Quinta; Hemani, Gibran; Henders, Anjali K.; Hillege, Hans L.; Hlatky, Mark A.; Hoffmann, Wolfgang; Hoffmann, Per; Holmen, Oddgeir; Houwing-Duistermaat, Jeanine J.; Illig, Thomas; Isaacs, Aaron; James, Alan L.; Jeff, Janina; Johansen, Berit; Johansson, Åsa; Jolley, Jennifer; Juliusdottir, Thorhildur; Junttila, Juhani; Kho, Abel N.; Kinnunen, Leena; Klopp, Norman; Kocher, Thomas; Kratzer, Wolfgang; Lichtner, Peter; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; Lorentzon, Mattias; Lu, Yingchang; Lyssenko, Valeriya; Magnusson, Patrik K.E.; Mahajan, Anubha; Maillard, Marc; McArdle, Wendy L.; McKenzie, Colin A.; McLachlan, Stela; McLaren, Paul J.; Menni, Cristina; Merger, Sigrun; Milani, Lili; Moayyeri, Alireza; Monda, Keri L.; Morken, Mario A.; Müller, Gabriele; Müller-Nurasyid, Martina; Musk, Arthur W.; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M.; Nöthen, Markus M.; Oozageer, Laticia; Pilz, Stefan; Rayner, Nigel W.; Renstrom, Frida; Robertson, Neil R.; Rose, Lynda M.; Roussel, Ronan; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Schumacher, Fredrick R.; Schunkert, Heribert; Scott, Robert A.; Sehmi, Joban; Seufferlein, Thomas; Shi, Jianxin; Silventoinen, Karri; Smit, Johannes H.; Smith, Albert Vernon; Smolonska, Joanna; Stanton, Alice V.; Stirrups, Kathleen; Stott, David J.; Stringham, Heather M.; Sundström, Johan; Swertz, Morris A.; Syvänen, Ann Christine; Tayo, Bamidele O.; Thorleifsson, Gudmar; Tyrer, Jonathan P.; Van Dijk, Suzanne; Van Schoor, Natasja M.; Van Der Velde, Nathalie; Van Heemst, Diana; Van Oort, Floor V.A.; Vermeulen, Sita H.; Verweij, Niek; Vonk, Judith M.; Waite, Lindsay L.; Waldenberger, Melanie; Wennauer, Roman; Wilkens, Lynne R.; Willenborg, Christina; Wilsgaard, Tom; Wojczynski, Mary K.; Wong, Andrew; Wright, Alan F.; Zhang, Qunyuan; Arveiler, Dominique; Bakker, Stephan J.L.; Beilby, John; Bergman, Richard N.; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boomsma, Dorret I.; Bornstein, Stefan R.; Bovet, Pascal; Brambilla, Paolo; Brown, Morris J.; Campbell, Harry; Caulfield, Mark J.; Chakravarti, Aravinda; Collins, Rory; Collins, Francis S.; Crawford, Dana C.; Cupples, L. Adrienne; Danesh, John; De Faire, Ulf; Den Ruijter, Hester M.; Erbel, Raimund; Erdmann, Jeanette; Eriksson, Johan G.; Farrall, Martin; Ferrannini, Ele; Ferrières, Jean; Ford, Ian; Forouhi, Nita G.; Forrester, Terrence; Gansevoort, Ron T.; Gejman, Pablo V.; Gieger, Christian; Golay, Alain; Gottesman, Omri; Gudnason, Vilmundur; Gyllensten, Ulf; Haas, David W.; Hall, Alistair S.; Harris, Tamara B.; Hattersley, Andrew T.; Heath, Andrew C.; Hengstenberg, Christian; Hicks, Andrew A.; Hindorff, Lucia A.; Hingorani, Aroon D.; Hofman, Albert; Hovingh, G. Kees; Humphries, Steve E.; Hunt, Steven; Hypponen, Elina; Jacobs, Kevin B.; Jarvelin, Marjo Riitta; Jousilahti, Pekka; Jula, Antti M.; Kaprio, Jaakko; Kastelein, John J.P.; Kayser, Manfred; Kee, Frank; Keinanen-Kiukaanniemi, Sirkka M.; Kiemeney, Lambertus A.; Kooner, Jaspal S.; Kooperberg, Charles; Koskinen, Seppo; Kovacs, Peter; Kraja, Aldi T.; Kumari, Meena; Kuusisto, Johanna; Lakka, Timo A.; Langenberg, Claudia; Le Marchand, Loic; Lehtimäki, Terho; Lupoli, Sara; Madden, Pamela A.F.; Männistö, Satu; Manunta, Paolo; Marette, André; Matise, Tara C.; McKnight, Barbara; Meitinger, Thomas; Moll, Frans L.; Montgomery, Grant W.; Morris, Andrew D.; Morris, Andrew P.; Murray, Jeffrey C.; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J.; Ong, Ken K.; Ouwehand, Willem H.; Pasterkamp, Gerard; Peters, Annette; Pramstaller, Peter P.; Price, Jackie F.; Qi, Lu; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rice, Treva K.; Ritchie, Marylyn; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J.; Saramies, Jouko; Sarzynski, Mark A.; Schwarz, Peter E.H.; Sebert, Sylvain; Sever, Peter; Shuldiner, Alan R.; Sinisalo, Juha; Steinthorsdottir, Valgerdur; Stolk, Ronald P.; Tardif, Jean Claude; Tönjes, Anke; Tremblay, Angelo; Tremoli, Elena; Virtamo, Jarmo; Vohl, Marie Claude; Amouyel, Philippe; Asselbergs, Folkert W.; Assimes, Themistocles L.; Bochud, Murielle; Boehm, Bernhard O.; Boerwinkle, Eric; Bottinger, Erwin P.; Bouchard, Claude; Cauchi, Stéphane; Chambers, John C.; Chanock, Stephen J.; Cooper, Richard S.; De Bakker, Paul I.W.; Dedoussis, George; Ferrucci, Luigi; Franks, Paul W.; Froguel, Philippe; Groop, Leif C.; Haiman, Christopher A.; Hamsten, Anders; Hayes, M. Geoffrey; Hui, Jennie; Hunter, David J.; Hveem, Kristian; Jukema, J. Wouter; Kaplan, Robert C.; Kivimaki, Mika; Kuh, Diana; Laakso, Markku; Liu, Yongmei; Martin, Nicholas G.; März, Winfried; Melbye, Mads; Moebus, Susanne; Munroe, Patricia B.; Njølstad, Inger; Oostra, Ben A.; Palmer, Colin N.A.; Pedersen, Nancy L.; Perola, Markus; Pérusse, Louis; Peters, Ulrike; Powell, Joseph E.; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Reinmaa, Eva; Ridker, Paul M.; Rivadeneira, Fernando; Rotter, Jerome I.; Saaristo, Timo E.; Saleheen, Danish; Schlessinger, David; Slagboom, P. Eline; Snieder, Harold; Spector, Tim D.; Strauch, Konstantin; Stumvoll, Michael; Tuomilehto, Jaakko; Uusitupa, Matti; Van Der Harst, Pim; Völzke, Henry; Walker, Mark; Wareham, Nicholas J.; Watkins, Hugh; Wichmann, H. Erich; Wilson, James F.; Zanen, Pieter; Deloukas, Panos; Heid, Iris M.; Lindgren, Cecilia M.; Mohlke, Karen L.; Speliotes, Elizabeth K.; Thorsteinsdottir, Unnur; Barroso, Inês; Fox, Caroline S.; North, Kari E.; Strachan, David P.; Beckmann, Jacques S.; Berndt, Sonja I.; Boehnke, Michael; Borecki, Ingrid B.; McCarthy, Mark I.; Metspalu, Andres; Stefansson, Kari; Uitterlinden, André G.; Van Duijn, Cornelia M.; Franke, Lude; Willer, Cristen J.; Price, Alkes L.; Lettre, Guillaume; Loos, Ruth J.F.; Weedon, Michael N.; Ingelsson, Erik; O'Connell, Jeffrey R.; Abecasis, Goncalo R.; Chasman, Daniel I.; Goddard, Michael E.; Visscher, Peter M.; Hirschhorn, Joel N.; Frayling, Timothy M.

In: Nature Genetics, Vol. 46, No. 11, 05.11.2014, p. 1173-1186.

Research output: Contribution to journalArticle

Wood, AR, Esko, T, Yang, J, Vedantam, S, Pers, TH, Gustafsson, S, Chu, AY, Estrada, K, Luan, JA, Kutalik, Z, Amin, N, Buchkovich, ML, Croteau-Chonka, DC, Day, FR, Duan, Y, Fall, T, Fehrmann, R, Ferreira, T, Jackson, AU, Karjalainen, J, Lo, KS, Locke, AE, Mägi, R, Mihailov, E, Porcu, E, Randall, JC, Scherag, A, Vinkhuyzen, AAE, Westra, HJ, Winkler, TW, Workalemahu, T, Zhao, JH, Absher, D, Albrecht, E, Anderson, D, Baron, J, Beekman, M, Demirkan, A, Ehret, GB, Feenstra, B, Feitosa, MF, Fischer, K, Fraser, RM, Goel, A, Gong, J, Justice, AE, Kanoni, S, Kleber, ME, Kristiansson, K, Lim, U, Lotay, V, Lui, JC, Mangino, M, Leach, IM, Medina-Gomez, C, Nalls, MA, Nyholt, DR, Palmer, CD, Pasko, D, Pechlivanis, S, Prokopenko, I, Ried, JS, Ripke, S, Shungin, D, Stancáková, A, Strawbridge, RJ, Sung, YJ, Tanaka, T, Teumer, A, Trompet, S, Van Der Laan, SW, Van Setten, J, Van Vliet-Ostaptchouk, JV, Wang, Z, Yengo, L, Zhang, W, Afzal, U, Ärnlöv, J, Arscott, GM, Bandinelli, S, Barrett, A, Bellis, C, Bennett, AJ, Berne, C, Blüher, M, Bolton, JL, Böttcher, Y, Boyd, HA, Bruinenberg, M, Buckley, BM, Buyske, S, Caspersen, IH, Chines, PS, Clarke, R, Claudi-Boehm, S, Cooper, M, Daw, EW, De Jong, PA, Deelen, J, Delgado, G, Denny, JC, Dhonukshe-Rutten, R, Dimitriou, M, Doney, ASF, Dörr, M, Eklund, N, Eury, E, Folkersen, L, Garcia, ME, Geller, F, Giedraitis, V, Go, AS, Grallert, H, Grammer, TB, Gräßler, J, Grönberg, H, De Groot, LCPGM, Groves, CJ, Haessler, J, Hall, P, Haller, T, Hallmans, G, Hannemann, A, Hartman, CA, Hassinen, M, Hayward, C, Heard-Costa, NL, Helmer, Q, Hemani, G, Henders, AK, Hillege, HL, Hlatky, MA, Hoffmann, W, Hoffmann, P, Holmen, O, Houwing-Duistermaat, JJ, Illig, T, Isaacs, A, James, AL, Jeff, J, Johansen, B, Johansson, Å, Jolley, J, Juliusdottir, T, Junttila, J, Kho, AN, Kinnunen, L, Klopp, N, Kocher, T, Kratzer, W, Lichtner, P, Lind, L, Lindström, J, Lobbens, S, Lorentzon, M, Lu, Y, Lyssenko, V, Magnusson, PKE, Mahajan, A, Maillard, M, McArdle, WL, McKenzie, CA, McLachlan, S, McLaren, PJ, Menni, C, Merger, S, Milani, L, Moayyeri, A, Monda, KL, Morken, MA, Müller, G, Müller-Nurasyid, M, Musk, AW, Narisu, N, Nauck, M, Nolte, IM, Nöthen, MM, Oozageer, L, Pilz, S, Rayner, NW, Renstrom, F, Robertson, NR, Rose, LM, Roussel, R, Sanna, S, Scharnagl, H, Scholtens, S, Schumacher, FR, Schunkert, H, Scott, RA, Sehmi, J, Seufferlein, T, Shi, J, Silventoinen, K, Smit, JH, Smith, AV, Smolonska, J, Stanton, AV, Stirrups, K, Stott, DJ, Stringham, HM, Sundström, J, Swertz, MA, Syvänen, AC, Tayo, BO, Thorleifsson, G, Tyrer, JP, Van Dijk, S, Van Schoor, NM, Van Der Velde, N, Van Heemst, D, Van Oort, FVA, Vermeulen, SH, Verweij, N, Vonk, JM, Waite, LL, Waldenberger, M, Wennauer, R, Wilkens, LR, Willenborg, C, Wilsgaard, T, Wojczynski, MK, Wong, A, Wright, AF, Zhang, Q, Arveiler, D, Bakker, SJL, Beilby, J, Bergman, RN, Bergmann, S, Biffar, R, Blangero, J, Boomsma, DI, Bornstein, SR, Bovet, P, Brambilla, P, Brown, MJ, Campbell, H, Caulfield, MJ, Chakravarti, A, Collins, R, Collins, FS, Crawford, DC, Cupples, LA, Danesh, J, De Faire, U, Den Ruijter, HM, Erbel, R, Erdmann, J, Eriksson, JG, Farrall, M, Ferrannini, E, Ferrières, J, Ford, I, Forouhi, NG, Forrester, T, Gansevoort, RT, Gejman, PV, Gieger, C, Golay, A, Gottesman, O, Gudnason, V, Gyllensten, U, Haas, DW, Hall, AS, Harris, TB, Hattersley, AT, Heath, AC, Hengstenberg, C, Hicks, AA, Hindorff, LA, Hingorani, AD, Hofman, A, Hovingh, GK, Humphries, SE, Hunt, S, Hypponen, E, Jacobs, KB, Jarvelin, MR, Jousilahti, P, Jula, AM, Kaprio, J, Kastelein, JJP, Kayser, M, Kee, F, Keinanen-Kiukaanniemi, SM, Kiemeney, LA, Kooner, JS, Kooperberg, C, Koskinen, S, Kovacs, P, Kraja, AT, Kumari, M, Kuusisto, J, Lakka, TA, Langenberg, C, Le Marchand, L, Lehtimäki, T, Lupoli, S, Madden, PAF, Männistö, S, Manunta, P, Marette, A, Matise, TC, McKnight, B, Meitinger, T, Moll, FL, Montgomery, GW, Morris, AD, Morris, AP, Murray, JC, Nelis, M, Ohlsson, C, Oldehinkel, AJ, Ong, KK, Ouwehand, WH, Pasterkamp, G, Peters, A, Pramstaller, PP, Price, JF, Qi, L, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Ritchie, M, Rudan, I, Salomaa, V, Samani, NJ, Saramies, J, Sarzynski, MA, Schwarz, PEH, Sebert, S, Sever, P, Shuldiner, AR, Sinisalo, J, Steinthorsdottir, V, Stolk, RP, Tardif, JC, Tönjes, A, Tremblay, A, Tremoli, E, Virtamo, J, Vohl, MC, Amouyel, P, Asselbergs, FW, Assimes, TL, Bochud, M, Boehm, BO, Boerwinkle, E, Bottinger, EP, Bouchard, C, Cauchi, S, Chambers, JC, Chanock, SJ, Cooper, RS, De Bakker, PIW, Dedoussis, G, Ferrucci, L, Franks, PW, Froguel, P, Groop, LC, Haiman, CA, Hamsten, A, Hayes, MG, Hui, J, Hunter, DJ, Hveem, K, Jukema, JW, Kaplan, RC, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Martin, NG, März, W, Melbye, M, Moebus, S, Munroe, PB, Njølstad, I, Oostra, BA, Palmer, CNA, Pedersen, NL, Perola, M, Pérusse, L, Peters, U, Powell, JE, Power, C, Quertermous, T, Rauramaa, R, Reinmaa, E, Ridker, PM, Rivadeneira, F, Rotter, JI, Saaristo, TE, Saleheen, D, Schlessinger, D, Slagboom, PE, Snieder, H, Spector, TD, Strauch, K, Stumvoll, M, Tuomilehto, J, Uusitupa, M, Van Der Harst, P, Völzke, H, Walker, M, Wareham, NJ, Watkins, H, Wichmann, HE, Wilson, JF, Zanen, P, Deloukas, P, Heid, IM, Lindgren, CM, Mohlke, KL, Speliotes, EK, Thorsteinsdottir, U, Barroso, I, Fox, CS, North, KE, Strachan, DP, Beckmann, JS, Berndt, SI, Boehnke, M, Borecki, IB, McCarthy, MI, Metspalu, A, Stefansson, K, Uitterlinden, AG, Van Duijn, CM, Franke, L, Willer, CJ, Price, AL, Lettre, G, Loos, RJF, Weedon, MN, Ingelsson, E, O'Connell, JR, Abecasis, GR, Chasman, DI, Goddard, ME, Visscher, PM, Hirschhorn, JN & Frayling, TM 2014, 'Defining the role of common variation in the genomic and biological architecture of adult human height', Nature Genetics, vol. 46, no. 11, pp. 1173-1186. https://doi.org/10.1038/ng.3097
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 2014 Nov 5;46(11):1173-1186. https://doi.org/10.1038/ng.3097
Wood, Andrew R. ; Esko, Tonu ; Yang, Jian ; Vedantam, Sailaja ; Pers, Tune H. ; Gustafsson, Stefan ; Chu, Audrey Y. ; Estrada, Karol ; Luan, Jian'An ; Kutalik, Zoltán ; Amin, Najaf ; Buchkovich, Martin L. ; Croteau-Chonka, Damien C. ; Day, Felix R. ; Duan, Yanan ; Fall, Tove ; Fehrmann, Rudolf ; Ferreira, Teresa ; Jackson, Anne U. ; Karjalainen, Juha ; Lo, Ken Sin ; Locke, Adam E. ; Mägi, Reedik ; Mihailov, Evelin ; Porcu, Eleonora ; Randall, Joshua C. ; Scherag, André ; Vinkhuyzen, Anna A.E. ; Westra, Harm Jan ; Winkler, Thomas W. ; Workalemahu, Tsegaselassie ; Zhao, Jing Hua ; Absher, Devin ; Albrecht, Eva ; Anderson, Denise ; Baron, Jeffrey ; Beekman, Marian ; Demirkan, Ayse ; Ehret, Georg B. ; Feenstra, Bjarke ; Feitosa, Mary F. ; Fischer, Krista ; Fraser, Ross M. ; Goel, Anuj ; Gong, Jian ; Justice, Anne E. ; Kanoni, Stavroula ; Kleber, Marcus E. ; Kristiansson, Kati ; Lim, Unhee ; Lotay, Vaneet ; Lui, Julian C. ; Mangino, Massimo ; Leach, Irene Mateo ; Medina-Gomez, Carolina ; Nalls, Michael A. ; Nyholt, Dale R. ; Palmer, Cameron D. ; Pasko, Dorota ; Pechlivanis, Sonali ; Prokopenko, Inga ; Ried, Janina S. ; Ripke, Stephan ; Shungin, Dmitry ; Stancáková, Alena ; Strawbridge, Rona J. ; Sung, Yun Ju ; Tanaka, Toshiko ; Teumer, Alexander ; Trompet, Stella ; Van Der Laan, Sander W. ; Van Setten, Jessica ; Van Vliet-Ostaptchouk, Jana V. ; Wang, Zhaoming ; Yengo, Loïc ; Zhang, Weihua ; Afzal, Uzma ; Ärnlöv, Johan ; Arscott, Gillian M. ; Bandinelli, Stefania ; Barrett, Amy ; Bellis, Claire ; Bennett, Amanda J. ; Berne, Christian ; Blüher, Matthias ; Bolton, Jennifer L. ; Böttcher, Yvonne ; Boyd, Heather A. ; Bruinenberg, Marcel ; Buckley, Brendan M. ; Buyske, Steven ; Caspersen, Ida H. ; Chines, Peter S. ; Clarke, Robert ; Claudi-Boehm, Simone ; Cooper, Matthew ; Daw, E. Warwick ; De Jong, Pim A. ; Deelen, Joris ; Delgado, Graciela ; Denny, Josh C. ; Dhonukshe-Rutten, Rosalie ; Dimitriou, Maria ; Doney, Alex S.F. ; Dörr, Marcus ; Eklund, Niina ; Eury, Elodie ; Folkersen, Lasse ; Garcia, Melissa E. ; Geller, Frank ; Giedraitis, Vilmantas ; Go, Alan S. ; Grallert, Harald ; Grammer, Tanja B. ; Gräßler, Jürgen ; Grönberg, Henrik ; De Groot, Lisette C.P.G.M. ; Groves, Christopher J. ; Haessler, Jeffrey ; Hall, Per ; Haller, Toomas ; Hallmans, Goran ; Hannemann, Anke ; Hartman, Catharina A. ; Hassinen, Maija ; Hayward, Caroline ; Heard-Costa, Nancy L. ; Helmer, Quinta ; Hemani, Gibran ; Henders, Anjali K. ; Hillege, Hans L. ; Hlatky, Mark A. ; Hoffmann, Wolfgang ; Hoffmann, Per ; Holmen, Oddgeir ; Houwing-Duistermaat, Jeanine J. ; Illig, Thomas ; Isaacs, Aaron ; James, Alan L. ; Jeff, Janina ; Johansen, Berit ; Johansson, Åsa ; Jolley, Jennifer ; Juliusdottir, Thorhildur ; Junttila, Juhani ; Kho, Abel N. ; Kinnunen, Leena ; Klopp, Norman ; Kocher, Thomas ; Kratzer, Wolfgang ; Lichtner, Peter ; Lind, Lars ; Lindström, Jaana ; Lobbens, Stéphane ; Lorentzon, Mattias ; Lu, Yingchang ; Lyssenko, Valeriya ; Magnusson, Patrik K.E. ; Mahajan, Anubha ; Maillard, Marc ; McArdle, Wendy L. ; McKenzie, Colin A. ; McLachlan, Stela ; McLaren, Paul J. ; Menni, Cristina ; Merger, Sigrun ; Milani, Lili ; Moayyeri, Alireza ; Monda, Keri L. ; Morken, Mario A. ; Müller, Gabriele ; Müller-Nurasyid, Martina ; Musk, Arthur W. ; Narisu, Narisu ; Nauck, Matthias ; Nolte, Ilja M. ; Nöthen, Markus M. ; Oozageer, Laticia ; Pilz, Stefan ; Rayner, Nigel W. ; Renstrom, Frida ; Robertson, Neil R. ; Rose, Lynda M. ; Roussel, Ronan ; Sanna, Serena ; Scharnagl, Hubert ; Scholtens, Salome ; Schumacher, Fredrick R. ; Schunkert, Heribert ; Scott, Robert A. ; Sehmi, Joban ; Seufferlein, Thomas ; Shi, Jianxin ; Silventoinen, Karri ; Smit, Johannes H. ; Smith, Albert Vernon ; Smolonska, Joanna ; Stanton, Alice V. ; Stirrups, Kathleen ; Stott, David J. ; Stringham, Heather M. ; Sundström, Johan ; Swertz, Morris A. ; Syvänen, Ann Christine ; Tayo, Bamidele O. ; Thorleifsson, Gudmar ; Tyrer, Jonathan P. ; Van Dijk, Suzanne ; Van Schoor, Natasja M. ; Van Der Velde, Nathalie ; Van Heemst, Diana ; Van Oort, Floor V.A. ; Vermeulen, Sita H. ; Verweij, Niek ; Vonk, Judith M. ; Waite, Lindsay L. ; Waldenberger, Melanie ; Wennauer, Roman ; Wilkens, Lynne R. ; Willenborg, Christina ; Wilsgaard, Tom ; Wojczynski, Mary K. ; Wong, Andrew ; Wright, Alan F. ; Zhang, Qunyuan ; Arveiler, Dominique ; Bakker, Stephan J.L. ; Beilby, John ; Bergman, Richard N. ; Bergmann, Sven ; Biffar, Reiner ; Blangero, John ; Boomsma, Dorret I. ; Bornstein, Stefan R. ; Bovet, Pascal ; Brambilla, Paolo ; Brown, Morris J. ; Campbell, Harry ; Caulfield, Mark J. ; Chakravarti, Aravinda ; Collins, Rory ; Collins, Francis S. ; Crawford, Dana C. ; Cupples, L. Adrienne ; Danesh, John ; De Faire, Ulf ; Den Ruijter, Hester M. ; Erbel, Raimund ; Erdmann, Jeanette ; Eriksson, Johan G. ; Farrall, Martin ; Ferrannini, Ele ; Ferrières, Jean ; Ford, Ian ; Forouhi, Nita G. ; Forrester, Terrence ; Gansevoort, Ron T. ; Gejman, Pablo V. ; Gieger, Christian ; Golay, Alain ; Gottesman, Omri ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Haas, David W. ; Hall, Alistair S. ; Harris, Tamara B. ; Hattersley, Andrew T. ; Heath, Andrew C. ; Hengstenberg, Christian ; Hicks, Andrew A. ; Hindorff, Lucia A. ; Hingorani, Aroon D. ; Hofman, Albert ; Hovingh, G. Kees ; Humphries, Steve E. ; Hunt, Steven ; Hypponen, Elina ; Jacobs, Kevin B. ; Jarvelin, Marjo Riitta ; Jousilahti, Pekka ; Jula, Antti M. ; Kaprio, Jaakko ; Kastelein, John J.P. ; Kayser, Manfred ; Kee, Frank ; Keinanen-Kiukaanniemi, Sirkka M. ; Kiemeney, Lambertus A. ; Kooner, Jaspal S. ; Kooperberg, Charles ; Koskinen, Seppo ; Kovacs, Peter ; Kraja, Aldi T. ; Kumari, Meena ; Kuusisto, Johanna ; Lakka, Timo A. ; Langenberg, Claudia ; Le Marchand, Loic ; Lehtimäki, Terho ; Lupoli, Sara ; Madden, Pamela A.F. ; Männistö, Satu ; Manunta, Paolo ; Marette, André ; Matise, Tara C. ; McKnight, Barbara ; Meitinger, Thomas ; Moll, Frans L. ; Montgomery, Grant W. ; Morris, Andrew D. ; Morris, Andrew P. ; Murray, Jeffrey C. ; Nelis, Mari ; Ohlsson, Claes ; Oldehinkel, Albertine J. ; Ong, Ken K. ; Ouwehand, Willem H. ; Pasterkamp, Gerard ; Peters, Annette ; Pramstaller, Peter P. ; Price, Jackie F. ; Qi, Lu ; Raitakari, Olli T. ; Rankinen, Tuomo ; Rao, D. C. ; Rice, Treva K. ; Ritchie, Marylyn ; Rudan, Igor ; Salomaa, Veikko ; Samani, Nilesh J. ; Saramies, Jouko ; Sarzynski, Mark A. ; Schwarz, Peter E.H. ; Sebert, Sylvain ; Sever, Peter ; Shuldiner, Alan R. ; Sinisalo, Juha ; Steinthorsdottir, Valgerdur ; Stolk, Ronald P. ; Tardif, Jean Claude ; Tönjes, Anke ; Tremblay, Angelo ; Tremoli, Elena ; Virtamo, Jarmo ; Vohl, Marie Claude ; Amouyel, Philippe ; Asselbergs, Folkert W. ; Assimes, Themistocles L. ; Bochud, Murielle ; Boehm, Bernhard O. ; Boerwinkle, Eric ; Bottinger, Erwin P. ; Bouchard, Claude ; Cauchi, Stéphane ; Chambers, John C. ; Chanock, Stephen J. ; Cooper, Richard S. ; De Bakker, Paul I.W. ; Dedoussis, George ; Ferrucci, Luigi ; Franks, Paul W. ; Froguel, Philippe ; Groop, Leif C. ; Haiman, Christopher A. ; Hamsten, Anders ; Hayes, M. Geoffrey ; Hui, Jennie ; Hunter, David J. ; Hveem, Kristian ; Jukema, J. Wouter ; Kaplan, Robert C. ; Kivimaki, Mika ; Kuh, Diana ; Laakso, Markku ; Liu, Yongmei ; Martin, Nicholas G. ; März, Winfried ; Melbye, Mads ; Moebus, Susanne ; Munroe, Patricia B. ; Njølstad, Inger ; Oostra, Ben A. ; Palmer, Colin N.A. ; Pedersen, Nancy L. ; Perola, Markus ; Pérusse, Louis ; Peters, Ulrike ; Powell, Joseph E. ; Power, Chris ; Quertermous, Thomas ; Rauramaa, Rainer ; Reinmaa, Eva ; Ridker, Paul M. ; Rivadeneira, Fernando ; Rotter, Jerome I. ; Saaristo, Timo E. ; Saleheen, Danish ; Schlessinger, David ; Slagboom, P. Eline ; Snieder, Harold ; Spector, Tim D. ; Strauch, Konstantin ; Stumvoll, Michael ; Tuomilehto, Jaakko ; Uusitupa, Matti ; Van Der Harst, Pim ; Völzke, Henry ; Walker, Mark ; Wareham, Nicholas J. ; Watkins, Hugh ; Wichmann, H. Erich ; Wilson, James F. ; Zanen, Pieter ; Deloukas, Panos ; Heid, Iris M. ; Lindgren, Cecilia M. ; Mohlke, Karen L. ; Speliotes, Elizabeth K. ; Thorsteinsdottir, Unnur ; Barroso, Inês ; Fox, Caroline S. ; North, Kari E. ; Strachan, David P. ; Beckmann, Jacques S. ; Berndt, Sonja I. ; Boehnke, Michael ; Borecki, Ingrid B. ; McCarthy, Mark I. ; Metspalu, Andres ; Stefansson, Kari ; Uitterlinden, André G. ; Van Duijn, Cornelia M. ; Franke, Lude ; Willer, Cristen J. ; Price, Alkes L. ; Lettre, Guillaume ; Loos, Ruth J.F. ; Weedon, Michael N. ; Ingelsson, Erik ; O'Connell, Jeffrey R. ; Abecasis, Goncalo R. ; Chasman, Daniel I. ; Goddard, Michael E. ; Visscher, Peter M. ; Hirschhorn, Joel N. ; Frayling, Timothy M. / Defining the role of common variation in the genomic and biological architecture of adult human height. In: Nature Genetics. 2014 ; Vol. 46, No. 11. pp. 1173-1186.
@article{51ea0d2f519d42e697380b83cf4fa8bb,
title = "Defining the role of common variation in the genomic and biological architecture of adult human height",
abstract = "Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421{\%}, 1/424{\%} and 1/429{\%} of phenotypic variance. Furthermore, all common variants together captured 60{\%} of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/I 2-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.",
author = "Wood, {Andrew R.} and Tonu Esko and Jian Yang and Sailaja Vedantam and Pers, {Tune H.} and Stefan Gustafsson and Chu, {Audrey Y.} and Karol Estrada and Jian'An Luan and Zolt{\'a}n Kutalik and Najaf Amin and Buchkovich, {Martin L.} and Croteau-Chonka, {Damien C.} and Day, {Felix R.} and Yanan Duan and Tove Fall and Rudolf Fehrmann and Teresa Ferreira and Jackson, {Anne U.} and Juha Karjalainen and Lo, {Ken Sin} and Locke, {Adam E.} and Reedik M{\"a}gi and Evelin Mihailov and Eleonora Porcu and Randall, {Joshua C.} and Andr{\'e} Scherag and Vinkhuyzen, {Anna A.E.} and Westra, {Harm Jan} and Winkler, {Thomas W.} and Tsegaselassie Workalemahu and Zhao, {Jing Hua} and Devin Absher and Eva Albrecht and Denise Anderson and Jeffrey Baron and Marian Beekman and Ayse Demirkan and Ehret, {Georg B.} and Bjarke Feenstra and Feitosa, {Mary F.} and Krista Fischer and Fraser, {Ross M.} and Anuj Goel and Jian Gong and Justice, {Anne E.} and Stavroula Kanoni and Kleber, {Marcus E.} and Kati Kristiansson and Unhee Lim and Vaneet Lotay and Lui, {Julian C.} and Massimo Mangino and Leach, {Irene Mateo} and Carolina Medina-Gomez and Nalls, {Michael A.} and Nyholt, {Dale R.} and Palmer, {Cameron D.} and Dorota Pasko and Sonali Pechlivanis and Inga Prokopenko and Ried, {Janina S.} and Stephan Ripke and Dmitry Shungin and Alena Stanc{\'a}kov{\'a} and Strawbridge, {Rona J.} and Sung, {Yun Ju} and Toshiko Tanaka and Alexander Teumer and Stella Trompet and {Van Der Laan}, {Sander W.} and {Van Setten}, Jessica and {Van Vliet-Ostaptchouk}, {Jana V.} and Zhaoming Wang and Lo{\"i}c Yengo and Weihua Zhang and Uzma Afzal and Johan {\"A}rnl{\"o}v and Arscott, {Gillian M.} and Stefania Bandinelli and Amy Barrett and Claire Bellis and Bennett, {Amanda J.} and Christian Berne and Matthias Bl{\"u}her and Bolton, {Jennifer L.} and Yvonne B{\"o}ttcher and Boyd, {Heather A.} and Marcel Bruinenberg and Buckley, {Brendan M.} and Steven Buyske and Caspersen, {Ida H.} and Chines, {Peter S.} and Robert Clarke and Simone Claudi-Boehm and Matthew Cooper and Daw, {E. Warwick} and {De Jong}, {Pim A.} and Joris Deelen and Graciela Delgado and Denny, {Josh C.} and Rosalie Dhonukshe-Rutten and Maria Dimitriou and Doney, {Alex S.F.} and Marcus D{\"o}rr and Niina Eklund and Elodie Eury and Lasse Folkersen and Garcia, {Melissa E.} and Frank Geller and Vilmantas Giedraitis and Go, {Alan S.} and Harald Grallert and Grammer, {Tanja B.} and J{\"u}rgen Gr{\"a}{\ss}ler and Henrik Gr{\"o}nberg and {De Groot}, {Lisette C.P.G.M.} and Groves, {Christopher J.} and Jeffrey Haessler and Per Hall and Toomas Haller and Goran Hallmans and Anke Hannemann and Hartman, {Catharina A.} and Maija Hassinen and Caroline Hayward and Heard-Costa, {Nancy L.} and Quinta Helmer and Gibran Hemani and Henders, {Anjali K.} and Hillege, {Hans L.} and Hlatky, {Mark A.} and Wolfgang Hoffmann and Per Hoffmann and Oddgeir Holmen and Houwing-Duistermaat, {Jeanine J.} and Thomas Illig and Aaron Isaacs and James, {Alan L.} and Janina Jeff and Berit Johansen and {\AA}sa Johansson and Jennifer Jolley and Thorhildur Juliusdottir and Juhani Junttila and Kho, {Abel N.} and Leena Kinnunen and Norman Klopp and Thomas Kocher and Wolfgang Kratzer and Peter Lichtner and Lars Lind and Jaana Lindstr{\"o}m and St{\'e}phane Lobbens and Mattias Lorentzon and Yingchang Lu and Valeriya Lyssenko and Magnusson, {Patrik K.E.} and Anubha Mahajan and Marc Maillard and McArdle, {Wendy L.} and McKenzie, {Colin A.} and Stela McLachlan and McLaren, {Paul J.} and Cristina Menni and Sigrun Merger and Lili Milani and Alireza Moayyeri and Monda, {Keri L.} and Morken, {Mario A.} and Gabriele M{\"u}ller and Martina M{\"u}ller-Nurasyid and Musk, {Arthur W.} and Narisu Narisu and Matthias Nauck and Nolte, {Ilja M.} and N{\"o}then, {Markus M.} and Laticia Oozageer and Stefan Pilz and Rayner, {Nigel W.} and Frida Renstrom and Robertson, {Neil R.} and Rose, {Lynda M.} and Ronan Roussel and Serena Sanna and Hubert Scharnagl and Salome Scholtens and Schumacher, {Fredrick R.} and Heribert Schunkert and Scott, {Robert A.} and Joban Sehmi and Thomas Seufferlein and Jianxin Shi and Karri Silventoinen and Smit, {Johannes H.} and Smith, {Albert Vernon} and Joanna Smolonska and Stanton, {Alice V.} and Kathleen Stirrups and Stott, {David J.} and Stringham, {Heather M.} and Johan Sundstr{\"o}m and Swertz, {Morris A.} and Syv{\"a}nen, {Ann Christine} and Tayo, {Bamidele O.} and Gudmar Thorleifsson and Tyrer, {Jonathan P.} and {Van Dijk}, Suzanne and {Van Schoor}, {Natasja M.} and {Van Der Velde}, Nathalie and {Van Heemst}, Diana and {Van Oort}, {Floor V.A.} and Vermeulen, {Sita H.} and Niek Verweij and Vonk, {Judith M.} and Waite, {Lindsay L.} and Melanie Waldenberger and Roman Wennauer and Wilkens, {Lynne R.} and Christina Willenborg and Tom Wilsgaard and Wojczynski, {Mary K.} and Andrew Wong and Wright, {Alan F.} and Qunyuan Zhang and Dominique Arveiler and Bakker, {Stephan J.L.} and John Beilby and Bergman, {Richard N.} and Sven Bergmann and Reiner Biffar and John Blangero and Boomsma, {Dorret I.} and Bornstein, {Stefan R.} and Pascal Bovet and Paolo Brambilla and Brown, {Morris J.} and Harry Campbell and Caulfield, {Mark J.} and Aravinda Chakravarti and Rory Collins and Collins, {Francis S.} and Crawford, {Dana C.} and Cupples, {L. Adrienne} and John Danesh and {De Faire}, Ulf and {Den Ruijter}, {Hester M.} and Raimund Erbel and Jeanette Erdmann and Eriksson, {Johan G.} and Martin Farrall and Ele Ferrannini and Jean Ferri{\`e}res and Ian Ford and Forouhi, {Nita G.} and Terrence Forrester and Gansevoort, {Ron T.} and Gejman, {Pablo V.} and Christian Gieger and Alain Golay and Omri Gottesman and Vilmundur Gudnason and Ulf Gyllensten and Haas, {David W.} and Hall, {Alistair S.} and Harris, {Tamara B.} and Hattersley, {Andrew T.} and Heath, {Andrew C.} and Christian Hengstenberg and Hicks, {Andrew A.} and Hindorff, {Lucia A.} and Hingorani, {Aroon D.} and Albert Hofman and Hovingh, {G. Kees} and Humphries, {Steve E.} and Steven Hunt and Elina Hypponen and Jacobs, {Kevin B.} and Jarvelin, {Marjo Riitta} and Pekka Jousilahti and Jula, {Antti M.} and Jaakko Kaprio and Kastelein, {John J.P.} and Manfred Kayser and Frank Kee and Keinanen-Kiukaanniemi, {Sirkka M.} and Kiemeney, {Lambertus A.} and Kooner, {Jaspal S.} and Charles Kooperberg and Seppo Koskinen and Peter Kovacs and Kraja, {Aldi T.} and Meena Kumari and Johanna Kuusisto and Lakka, {Timo A.} and Claudia Langenberg and {Le Marchand}, Loic and Terho Lehtim{\"a}ki and Sara Lupoli and Madden, {Pamela A.F.} and Satu M{\"a}nnist{\"o} and Paolo Manunta and Andr{\'e} Marette and Matise, {Tara C.} and Barbara McKnight and Thomas Meitinger and Moll, {Frans L.} and Montgomery, {Grant W.} and Morris, {Andrew D.} and Morris, {Andrew P.} and Murray, {Jeffrey C.} and Mari Nelis and Claes Ohlsson and Oldehinkel, {Albertine J.} and Ong, {Ken K.} and Ouwehand, {Willem H.} and Gerard Pasterkamp and Annette Peters and Pramstaller, {Peter P.} and Price, {Jackie F.} and Lu Qi and Raitakari, {Olli T.} and Tuomo Rankinen and Rao, {D. C.} and Rice, {Treva K.} and Marylyn Ritchie and Igor Rudan and Veikko Salomaa and Samani, {Nilesh J.} and Jouko Saramies and Sarzynski, {Mark A.} and Schwarz, {Peter E.H.} and Sylvain Sebert and Peter Sever and Shuldiner, {Alan R.} and Juha Sinisalo and Valgerdur Steinthorsdottir and Stolk, {Ronald P.} and Tardif, {Jean Claude} and Anke T{\"o}njes and Angelo Tremblay and Elena Tremoli and Jarmo Virtamo and Vohl, {Marie Claude} and Philippe Amouyel and Asselbergs, {Folkert W.} and Assimes, {Themistocles L.} and Murielle Bochud and Boehm, {Bernhard O.} and Eric Boerwinkle and Bottinger, {Erwin P.} and Claude Bouchard and St{\'e}phane Cauchi and Chambers, {John C.} and Chanock, {Stephen J.} and Cooper, {Richard S.} and {De Bakker}, {Paul I.W.} and George Dedoussis and Luigi Ferrucci and Franks, {Paul W.} and Philippe Froguel and Groop, {Leif C.} and Haiman, {Christopher A.} and Anders Hamsten and Hayes, {M. Geoffrey} and Jennie Hui and Hunter, {David J.} and Kristian Hveem and Jukema, {J. Wouter} and Kaplan, {Robert C.} and Mika Kivimaki and Diana Kuh and Markku Laakso and Yongmei Liu and Martin, {Nicholas G.} and Winfried M{\"a}rz and Mads Melbye and Susanne Moebus and Munroe, {Patricia B.} and Inger Nj{\o}lstad and Oostra, {Ben A.} and Palmer, {Colin N.A.} and Pedersen, {Nancy L.} and Markus Perola and Louis P{\'e}russe and Ulrike Peters and Powell, {Joseph E.} and Chris Power and Thomas Quertermous and Rainer Rauramaa and Eva Reinmaa and Ridker, {Paul M.} and Fernando Rivadeneira and Rotter, {Jerome I.} and Saaristo, {Timo E.} and Danish Saleheen and David Schlessinger and Slagboom, {P. Eline} and Harold Snieder and Spector, {Tim D.} and Konstantin Strauch and Michael Stumvoll and Jaakko Tuomilehto and Matti Uusitupa and {Van Der Harst}, Pim and Henry V{\"o}lzke and Mark Walker and Wareham, {Nicholas J.} and Hugh Watkins and Wichmann, {H. Erich} and Wilson, {James F.} and Pieter Zanen and Panos Deloukas and Heid, {Iris M.} and Lindgren, {Cecilia M.} and Mohlke, {Karen L.} and Speliotes, {Elizabeth K.} and Unnur Thorsteinsdottir and In{\^e}s Barroso and Fox, {Caroline S.} and North, {Kari E.} and Strachan, {David P.} and Beckmann, {Jacques S.} and Berndt, {Sonja I.} and Michael Boehnke and Borecki, {Ingrid B.} and McCarthy, {Mark I.} and Andres Metspalu and Kari Stefansson and Uitterlinden, {Andr{\'e} G.} and {Van Duijn}, {Cornelia M.} and Lude Franke and Willer, {Cristen J.} and Price, {Alkes L.} and Guillaume Lettre and Loos, {Ruth J.F.} and Weedon, {Michael N.} and Erik Ingelsson and O'Connell, {Jeffrey R.} and Abecasis, {Goncalo R.} and Chasman, {Daniel I.} and Goddard, {Michael E.} and Visscher, {Peter M.} and Hirschhorn, {Joel N.} and Frayling, {Timothy M.}",
year = "2014",
month = "11",
day = "5",
doi = "10.1038/ng.3097",
language = "English",
volume = "46",
pages = "1173--1186",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Defining the role of common variation in the genomic and biological architecture of adult human height

AU - Wood, Andrew R.

AU - Esko, Tonu

AU - Yang, Jian

AU - Vedantam, Sailaja

AU - Pers, Tune H.

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AU - Estrada, Karol

AU - Luan, Jian'An

AU - Kutalik, Zoltán

AU - Amin, Najaf

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AU - Croteau-Chonka, Damien C.

AU - Day, Felix R.

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AU - Mägi, Reedik

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AU - Porcu, Eleonora

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AU - Kleber, Marcus E.

AU - Kristiansson, Kati

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AU - Lotay, Vaneet

AU - Lui, Julian C.

AU - Mangino, Massimo

AU - Leach, Irene Mateo

AU - Medina-Gomez, Carolina

AU - Nalls, Michael A.

AU - Nyholt, Dale R.

AU - Palmer, Cameron D.

AU - Pasko, Dorota

AU - Pechlivanis, Sonali

AU - Prokopenko, Inga

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AU - Ripke, Stephan

AU - Shungin, Dmitry

AU - Stancáková, Alena

AU - Strawbridge, Rona J.

AU - Sung, Yun Ju

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AU - Teumer, Alexander

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AU - Wang, Zhaoming

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AU - Zhang, Weihua

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AU - Bellis, Claire

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AU - Böttcher, Yvonne

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AU - Clarke, Robert

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AU - Cooper, Matthew

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AU - Delgado, Graciela

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AU - Dhonukshe-Rutten, Rosalie

AU - Dimitriou, Maria

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AU - Folkersen, Lasse

AU - Garcia, Melissa E.

AU - Geller, Frank

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AU - Go, Alan S.

AU - Grallert, Harald

AU - Grammer, Tanja B.

AU - Gräßler, Jürgen

AU - Grönberg, Henrik

AU - De Groot, Lisette C.P.G.M.

AU - Groves, Christopher J.

AU - Haessler, Jeffrey

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AU - Hassinen, Maija

AU - Hayward, Caroline

AU - Heard-Costa, Nancy L.

AU - Helmer, Quinta

AU - Hemani, Gibran

AU - Henders, Anjali K.

AU - Hillege, Hans L.

AU - Hlatky, Mark A.

AU - Hoffmann, Wolfgang

AU - Hoffmann, Per

AU - Holmen, Oddgeir

AU - Houwing-Duistermaat, Jeanine J.

AU - Illig, Thomas

AU - Isaacs, Aaron

AU - James, Alan L.

AU - Jeff, Janina

AU - Johansen, Berit

AU - Johansson, Åsa

AU - Jolley, Jennifer

AU - Juliusdottir, Thorhildur

AU - Junttila, Juhani

AU - Kho, Abel N.

AU - Kinnunen, Leena

AU - Klopp, Norman

AU - Kocher, Thomas

AU - Kratzer, Wolfgang

AU - Lichtner, Peter

AU - Lind, Lars

AU - Lindström, Jaana

AU - Lobbens, Stéphane

AU - Lorentzon, Mattias

AU - Lu, Yingchang

AU - Lyssenko, Valeriya

AU - Magnusson, Patrik K.E.

AU - Mahajan, Anubha

AU - Maillard, Marc

AU - McArdle, Wendy L.

AU - McKenzie, Colin A.

AU - McLachlan, Stela

AU - McLaren, Paul J.

AU - Menni, Cristina

AU - Merger, Sigrun

AU - Milani, Lili

AU - Moayyeri, Alireza

AU - Monda, Keri L.

AU - Morken, Mario A.

AU - Müller, Gabriele

AU - Müller-Nurasyid, Martina

AU - Musk, Arthur W.

AU - Narisu, Narisu

AU - Nauck, Matthias

AU - Nolte, Ilja M.

AU - Nöthen, Markus M.

AU - Oozageer, Laticia

AU - Pilz, Stefan

AU - Rayner, Nigel W.

AU - Renstrom, Frida

AU - Robertson, Neil R.

AU - Rose, Lynda M.

AU - Roussel, Ronan

AU - Sanna, Serena

AU - Scharnagl, Hubert

AU - Scholtens, Salome

AU - Schumacher, Fredrick R.

AU - Schunkert, Heribert

AU - Scott, Robert A.

AU - Sehmi, Joban

AU - Seufferlein, Thomas

AU - Shi, Jianxin

AU - Silventoinen, Karri

AU - Smit, Johannes H.

AU - Smith, Albert Vernon

AU - Smolonska, Joanna

AU - Stanton, Alice V.

AU - Stirrups, Kathleen

AU - Stott, David J.

AU - Stringham, Heather M.

AU - Sundström, Johan

AU - Swertz, Morris A.

AU - Syvänen, Ann Christine

AU - Tayo, Bamidele O.

AU - Thorleifsson, Gudmar

AU - Tyrer, Jonathan P.

AU - Van Dijk, Suzanne

AU - Van Schoor, Natasja M.

AU - Van Der Velde, Nathalie

AU - Van Heemst, Diana

AU - Van Oort, Floor V.A.

AU - Vermeulen, Sita H.

AU - Verweij, Niek

AU - Vonk, Judith M.

AU - Waite, Lindsay L.

AU - Waldenberger, Melanie

AU - Wennauer, Roman

AU - Wilkens, Lynne R.

AU - Willenborg, Christina

AU - Wilsgaard, Tom

AU - Wojczynski, Mary K.

AU - Wong, Andrew

AU - Wright, Alan F.

AU - Zhang, Qunyuan

AU - Arveiler, Dominique

AU - Bakker, Stephan J.L.

AU - Beilby, John

AU - Bergman, Richard N.

AU - Bergmann, Sven

AU - Biffar, Reiner

AU - Blangero, John

AU - Boomsma, Dorret I.

AU - Bornstein, Stefan R.

AU - Bovet, Pascal

AU - Brambilla, Paolo

AU - Brown, Morris J.

AU - Campbell, Harry

AU - Caulfield, Mark J.

AU - Chakravarti, Aravinda

AU - Collins, Rory

AU - Collins, Francis S.

AU - Crawford, Dana C.

AU - Cupples, L. Adrienne

AU - Danesh, John

AU - De Faire, Ulf

AU - Den Ruijter, Hester M.

AU - Erbel, Raimund

AU - Erdmann, Jeanette

AU - Eriksson, Johan G.

AU - Farrall, Martin

AU - Ferrannini, Ele

AU - Ferrières, Jean

AU - Ford, Ian

AU - Forouhi, Nita G.

AU - Forrester, Terrence

AU - Gansevoort, Ron T.

AU - Gejman, Pablo V.

AU - Gieger, Christian

AU - Golay, Alain

AU - Gottesman, Omri

AU - Gudnason, Vilmundur

AU - Gyllensten, Ulf

AU - Haas, David W.

AU - Hall, Alistair S.

AU - Harris, Tamara B.

AU - Hattersley, Andrew T.

AU - Heath, Andrew C.

AU - Hengstenberg, Christian

AU - Hicks, Andrew A.

AU - Hindorff, Lucia A.

AU - Hingorani, Aroon D.

AU - Hofman, Albert

AU - Hovingh, G. Kees

AU - Humphries, Steve E.

AU - Hunt, Steven

AU - Hypponen, Elina

AU - Jacobs, Kevin B.

AU - Jarvelin, Marjo Riitta

AU - Jousilahti, Pekka

AU - Jula, Antti M.

AU - Kaprio, Jaakko

AU - Kastelein, John J.P.

AU - Kayser, Manfred

AU - Kee, Frank

AU - Keinanen-Kiukaanniemi, Sirkka M.

AU - Kiemeney, Lambertus A.

AU - Kooner, Jaspal S.

AU - Kooperberg, Charles

AU - Koskinen, Seppo

AU - Kovacs, Peter

AU - Kraja, Aldi T.

AU - Kumari, Meena

AU - Kuusisto, Johanna

AU - Lakka, Timo A.

AU - Langenberg, Claudia

AU - Le Marchand, Loic

AU - Lehtimäki, Terho

AU - Lupoli, Sara

AU - Madden, Pamela A.F.

AU - Männistö, Satu

AU - Manunta, Paolo

AU - Marette, André

AU - Matise, Tara C.

AU - McKnight, Barbara

AU - Meitinger, Thomas

AU - Moll, Frans L.

AU - Montgomery, Grant W.

AU - Morris, Andrew D.

AU - Morris, Andrew P.

AU - Murray, Jeffrey C.

AU - Nelis, Mari

AU - Ohlsson, Claes

AU - Oldehinkel, Albertine J.

AU - Ong, Ken K.

AU - Ouwehand, Willem H.

AU - Pasterkamp, Gerard

AU - Peters, Annette

AU - Pramstaller, Peter P.

AU - Price, Jackie F.

AU - Qi, Lu

AU - Raitakari, Olli T.

AU - Rankinen, Tuomo

AU - Rao, D. C.

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AU - Ritchie, Marylyn

AU - Rudan, Igor

AU - Salomaa, Veikko

AU - Samani, Nilesh J.

AU - Saramies, Jouko

AU - Sarzynski, Mark A.

AU - Schwarz, Peter E.H.

AU - Sebert, Sylvain

AU - Sever, Peter

AU - Shuldiner, Alan R.

AU - Sinisalo, Juha

AU - Steinthorsdottir, Valgerdur

AU - Stolk, Ronald P.

AU - Tardif, Jean Claude

AU - Tönjes, Anke

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AU - Tremoli, Elena

AU - Virtamo, Jarmo

AU - Vohl, Marie Claude

AU - Amouyel, Philippe

AU - Asselbergs, Folkert W.

AU - Assimes, Themistocles L.

AU - Bochud, Murielle

AU - Boehm, Bernhard O.

AU - Boerwinkle, Eric

AU - Bottinger, Erwin P.

AU - Bouchard, Claude

AU - Cauchi, Stéphane

AU - Chambers, John C.

AU - Chanock, Stephen J.

AU - Cooper, Richard S.

AU - De Bakker, Paul I.W.

AU - Dedoussis, George

AU - Ferrucci, Luigi

AU - Franks, Paul W.

AU - Froguel, Philippe

AU - Groop, Leif C.

AU - Haiman, Christopher A.

AU - Hamsten, Anders

AU - Hayes, M. Geoffrey

AU - Hui, Jennie

AU - Hunter, David J.

AU - Hveem, Kristian

AU - Jukema, J. Wouter

AU - Kaplan, Robert C.

AU - Kivimaki, Mika

AU - Kuh, Diana

AU - Laakso, Markku

AU - Liu, Yongmei

AU - Martin, Nicholas G.

AU - März, Winfried

AU - Melbye, Mads

AU - Moebus, Susanne

AU - Munroe, Patricia B.

AU - Njølstad, Inger

AU - Oostra, Ben A.

AU - Palmer, Colin N.A.

AU - Pedersen, Nancy L.

AU - Perola, Markus

AU - Pérusse, Louis

AU - Peters, Ulrike

AU - Powell, Joseph E.

AU - Power, Chris

AU - Quertermous, Thomas

AU - Rauramaa, Rainer

AU - Reinmaa, Eva

AU - Ridker, Paul M.

AU - Rivadeneira, Fernando

AU - Rotter, Jerome I.

AU - Saaristo, Timo E.

AU - Saleheen, Danish

AU - Schlessinger, David

AU - Slagboom, P. Eline

AU - Snieder, Harold

AU - Spector, Tim D.

AU - Strauch, Konstantin

AU - Stumvoll, Michael

AU - Tuomilehto, Jaakko

AU - Uusitupa, Matti

AU - Van Der Harst, Pim

AU - Völzke, Henry

AU - Walker, Mark

AU - Wareham, Nicholas J.

AU - Watkins, Hugh

AU - Wichmann, H. Erich

AU - Wilson, James F.

AU - Zanen, Pieter

AU - Deloukas, Panos

AU - Heid, Iris M.

AU - Lindgren, Cecilia M.

AU - Mohlke, Karen L.

AU - Speliotes, Elizabeth K.

AU - Thorsteinsdottir, Unnur

AU - Barroso, Inês

AU - Fox, Caroline S.

AU - North, Kari E.

AU - Strachan, David P.

AU - Beckmann, Jacques S.

AU - Berndt, Sonja I.

AU - Boehnke, Michael

AU - Borecki, Ingrid B.

AU - McCarthy, Mark I.

AU - Metspalu, Andres

AU - Stefansson, Kari

AU - Uitterlinden, André G.

AU - Van Duijn, Cornelia M.

AU - Franke, Lude

AU - Willer, Cristen J.

AU - Price, Alkes L.

AU - Lettre, Guillaume

AU - Loos, Ruth J.F.

AU - Weedon, Michael N.

AU - Ingelsson, Erik

AU - O'Connell, Jeffrey R.

AU - Abecasis, Goncalo R.

AU - Chasman, Daniel I.

AU - Goddard, Michael E.

AU - Visscher, Peter M.

AU - Hirschhorn, Joel N.

AU - Frayling, Timothy M.

PY - 2014/11/5

Y1 - 2014/11/5

N2 - Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/I 2-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

AB - Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/I 2-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

UR - http://www.scopus.com/inward/record.url?scp=84908890496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908890496&partnerID=8YFLogxK

U2 - 10.1038/ng.3097

DO - 10.1038/ng.3097

M3 - Article

VL - 46

SP - 1173

EP - 1186

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 11

ER -