Deep dermatophytosis and inherited CARD9 deficiency

Fanny Lanternier, Saad Pathan, Quentin B. Vincent, Luyan Liu, Sophie Cypowyj, Carolina Prando, Mélanie Migaud, Lynda Taibi, Aomar Ammar-Khodja, Omar Boudghene Stambouli, Boumediene Guellil, Frederique Jacobs, Jean Christophe Goffard, Kinda Schepers, Véronique Del Marmol, Lobna Boussofara, Mohamed Denguezli, Molka Larif, Hervé Bachelez, Laurence Michel & 13 others Gérard Lefranc, Rod Hay, Gregory Jouvion, Fabrice Chretien, Sylvie Fraitag, Marie Elisabeth Bougnoux, Merad Boudia, Laurent Abel, Olivier Lortholary, Jean Laurent Casanova, Capucine Picard, Bodo Grimbacher, Anne Puel

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

BACKGROUND: Deep dermatophytosis is a severe and sometimes life-threatening fungal infection caused by dermatophytes. It is characterized by extensive dermal and subcutaneous tissue invasion and by frequent dissemination to the lymph nodes and, occasionally, the central nervous system. The condition is different from common superficial dermatophyte infection and has been reported in patients with no known immunodeficiency. Patients are mostly from North African, consanguineous, multiplex families, which strongly suggests a mendelian genetic cause. METHODS: We studied the clinical features of deep dermatophytosis in 17 patients with no known immunodeficiency from eight unrelated Tunisian, Algerian, and Moroccan families. Because CARD9 (caspase recruitment domain-containing protein 9) deficiency has been reported in an Iranian family with invasive fungal infections, we also sequenced CARD9 in the patients. RESULTS: Four patients died, at 28, 29, 37, and 39 years of age, with clinically active deep dermatophytosis. No other severe infections, fungal or otherwise, were reported in the surviving patients, who ranged in age from 37 to 75 years. The 15 Algerian and Tunisian patients, from seven unrelated families, had a homozygous Q289X CARD9 allele, due to a founder effect. The 2 Moroccan siblings were homozygous for the R101C CARD9 allele. Both alleles are rare deleterious variants. The familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance. CONCLUSIONS: All the patients with deep dermatophytosis had autosomal recessive CARD9 deficiency. Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency.

Original languageEnglish
Pages (from-to)1704-1714
Number of pages11
JournalNew England Journal of Medicine
Volume369
Issue number18
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Protein Deficiency
Tinea
Alleles
Arthrodermataceae
Mycoses
Founder Effect
Proteins
Caspase Activation and Recruitment Domain
Penetrance
Subcutaneous Tissue
Siblings
Central Nervous System
Lymph Nodes
Skin
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lanternier, F., Pathan, S., Vincent, Q. B., Liu, L., Cypowyj, S., Prando, C., ... Puel, A. (2013). Deep dermatophytosis and inherited CARD9 deficiency. New England Journal of Medicine, 369(18), 1704-1714. https://doi.org/10.1056/NEJMoa1208487

Deep dermatophytosis and inherited CARD9 deficiency. / Lanternier, Fanny; Pathan, Saad; Vincent, Quentin B.; Liu, Luyan; Cypowyj, Sophie; Prando, Carolina; Migaud, Mélanie; Taibi, Lynda; Ammar-Khodja, Aomar; Stambouli, Omar Boudghene; Guellil, Boumediene; Jacobs, Frederique; Goffard, Jean Christophe; Schepers, Kinda; Del Marmol, Véronique; Boussofara, Lobna; Denguezli, Mohamed; Larif, Molka; Bachelez, Hervé; Michel, Laurence; Lefranc, Gérard; Hay, Rod; Jouvion, Gregory; Chretien, Fabrice; Fraitag, Sylvie; Bougnoux, Marie Elisabeth; Boudia, Merad; Abel, Laurent; Lortholary, Olivier; Casanova, Jean Laurent; Picard, Capucine; Grimbacher, Bodo; Puel, Anne.

In: New England Journal of Medicine, Vol. 369, No. 18, 2013, p. 1704-1714.

Research output: Contribution to journalArticle

Lanternier, F, Pathan, S, Vincent, QB, Liu, L, Cypowyj, S, Prando, C, Migaud, M, Taibi, L, Ammar-Khodja, A, Stambouli, OB, Guellil, B, Jacobs, F, Goffard, JC, Schepers, K, Del Marmol, V, Boussofara, L, Denguezli, M, Larif, M, Bachelez, H, Michel, L, Lefranc, G, Hay, R, Jouvion, G, Chretien, F, Fraitag, S, Bougnoux, ME, Boudia, M, Abel, L, Lortholary, O, Casanova, JL, Picard, C, Grimbacher, B & Puel, A 2013, 'Deep dermatophytosis and inherited CARD9 deficiency', New England Journal of Medicine, vol. 369, no. 18, pp. 1704-1714. https://doi.org/10.1056/NEJMoa1208487
Lanternier F, Pathan S, Vincent QB, Liu L, Cypowyj S, Prando C et al. Deep dermatophytosis and inherited CARD9 deficiency. New England Journal of Medicine. 2013;369(18):1704-1714. https://doi.org/10.1056/NEJMoa1208487
Lanternier, Fanny ; Pathan, Saad ; Vincent, Quentin B. ; Liu, Luyan ; Cypowyj, Sophie ; Prando, Carolina ; Migaud, Mélanie ; Taibi, Lynda ; Ammar-Khodja, Aomar ; Stambouli, Omar Boudghene ; Guellil, Boumediene ; Jacobs, Frederique ; Goffard, Jean Christophe ; Schepers, Kinda ; Del Marmol, Véronique ; Boussofara, Lobna ; Denguezli, Mohamed ; Larif, Molka ; Bachelez, Hervé ; Michel, Laurence ; Lefranc, Gérard ; Hay, Rod ; Jouvion, Gregory ; Chretien, Fabrice ; Fraitag, Sylvie ; Bougnoux, Marie Elisabeth ; Boudia, Merad ; Abel, Laurent ; Lortholary, Olivier ; Casanova, Jean Laurent ; Picard, Capucine ; Grimbacher, Bodo ; Puel, Anne. / Deep dermatophytosis and inherited CARD9 deficiency. In: New England Journal of Medicine. 2013 ; Vol. 369, No. 18. pp. 1704-1714.
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abstract = "BACKGROUND: Deep dermatophytosis is a severe and sometimes life-threatening fungal infection caused by dermatophytes. It is characterized by extensive dermal and subcutaneous tissue invasion and by frequent dissemination to the lymph nodes and, occasionally, the central nervous system. The condition is different from common superficial dermatophyte infection and has been reported in patients with no known immunodeficiency. Patients are mostly from North African, consanguineous, multiplex families, which strongly suggests a mendelian genetic cause. METHODS: We studied the clinical features of deep dermatophytosis in 17 patients with no known immunodeficiency from eight unrelated Tunisian, Algerian, and Moroccan families. Because CARD9 (caspase recruitment domain-containing protein 9) deficiency has been reported in an Iranian family with invasive fungal infections, we also sequenced CARD9 in the patients. RESULTS: Four patients died, at 28, 29, 37, and 39 years of age, with clinically active deep dermatophytosis. No other severe infections, fungal or otherwise, were reported in the surviving patients, who ranged in age from 37 to 75 years. The 15 Algerian and Tunisian patients, from seven unrelated families, had a homozygous Q289X CARD9 allele, due to a founder effect. The 2 Moroccan siblings were homozygous for the R101C CARD9 allele. Both alleles are rare deleterious variants. The familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance. CONCLUSIONS: All the patients with deep dermatophytosis had autosomal recessive CARD9 deficiency. Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency.",
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T1 - Deep dermatophytosis and inherited CARD9 deficiency

AU - Lanternier, Fanny

AU - Pathan, Saad

AU - Vincent, Quentin B.

AU - Liu, Luyan

AU - Cypowyj, Sophie

AU - Prando, Carolina

AU - Migaud, Mélanie

AU - Taibi, Lynda

AU - Ammar-Khodja, Aomar

AU - Stambouli, Omar Boudghene

AU - Guellil, Boumediene

AU - Jacobs, Frederique

AU - Goffard, Jean Christophe

AU - Schepers, Kinda

AU - Del Marmol, Véronique

AU - Boussofara, Lobna

AU - Denguezli, Mohamed

AU - Larif, Molka

AU - Bachelez, Hervé

AU - Michel, Laurence

AU - Lefranc, Gérard

AU - Hay, Rod

AU - Jouvion, Gregory

AU - Chretien, Fabrice

AU - Fraitag, Sylvie

AU - Bougnoux, Marie Elisabeth

AU - Boudia, Merad

AU - Abel, Laurent

AU - Lortholary, Olivier

AU - Casanova, Jean Laurent

AU - Picard, Capucine

AU - Grimbacher, Bodo

AU - Puel, Anne

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Deep dermatophytosis is a severe and sometimes life-threatening fungal infection caused by dermatophytes. It is characterized by extensive dermal and subcutaneous tissue invasion and by frequent dissemination to the lymph nodes and, occasionally, the central nervous system. The condition is different from common superficial dermatophyte infection and has been reported in patients with no known immunodeficiency. Patients are mostly from North African, consanguineous, multiplex families, which strongly suggests a mendelian genetic cause. METHODS: We studied the clinical features of deep dermatophytosis in 17 patients with no known immunodeficiency from eight unrelated Tunisian, Algerian, and Moroccan families. Because CARD9 (caspase recruitment domain-containing protein 9) deficiency has been reported in an Iranian family with invasive fungal infections, we also sequenced CARD9 in the patients. RESULTS: Four patients died, at 28, 29, 37, and 39 years of age, with clinically active deep dermatophytosis. No other severe infections, fungal or otherwise, were reported in the surviving patients, who ranged in age from 37 to 75 years. The 15 Algerian and Tunisian patients, from seven unrelated families, had a homozygous Q289X CARD9 allele, due to a founder effect. The 2 Moroccan siblings were homozygous for the R101C CARD9 allele. Both alleles are rare deleterious variants. The familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance. CONCLUSIONS: All the patients with deep dermatophytosis had autosomal recessive CARD9 deficiency. Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency.

AB - BACKGROUND: Deep dermatophytosis is a severe and sometimes life-threatening fungal infection caused by dermatophytes. It is characterized by extensive dermal and subcutaneous tissue invasion and by frequent dissemination to the lymph nodes and, occasionally, the central nervous system. The condition is different from common superficial dermatophyte infection and has been reported in patients with no known immunodeficiency. Patients are mostly from North African, consanguineous, multiplex families, which strongly suggests a mendelian genetic cause. METHODS: We studied the clinical features of deep dermatophytosis in 17 patients with no known immunodeficiency from eight unrelated Tunisian, Algerian, and Moroccan families. Because CARD9 (caspase recruitment domain-containing protein 9) deficiency has been reported in an Iranian family with invasive fungal infections, we also sequenced CARD9 in the patients. RESULTS: Four patients died, at 28, 29, 37, and 39 years of age, with clinically active deep dermatophytosis. No other severe infections, fungal or otherwise, were reported in the surviving patients, who ranged in age from 37 to 75 years. The 15 Algerian and Tunisian patients, from seven unrelated families, had a homozygous Q289X CARD9 allele, due to a founder effect. The 2 Moroccan siblings were homozygous for the R101C CARD9 allele. Both alleles are rare deleterious variants. The familial segregation of these alleles was consistent with autosomal recessive inheritance and complete clinical penetrance. CONCLUSIONS: All the patients with deep dermatophytosis had autosomal recessive CARD9 deficiency. Deep dermatophytosis appears to be an important clinical manifestation of CARD9 deficiency.

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