Decoding ARE-mediated decay: Is microRNA part of the equation?

Christopher Von Roretz, Imed Gallouzi

Research output: Contribution to journalShort survey

81 Citations (Scopus)

Abstract

Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalJournal of Cell Biology
Volume181
Issue number2
DOIs
Publication statusPublished - 21 Apr 2008
Externally publishedYes

Fingerprint

Uridine
Adenine
MicroRNAs
RNA
Oncogene Proteins
3' Untranslated Regions
Intercellular Signaling Peptides and Proteins
Cytokines

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Decoding ARE-mediated decay : Is microRNA part of the equation? / Von Roretz, Christopher; Gallouzi, Imed.

In: Journal of Cell Biology, Vol. 181, No. 2, 21.04.2008, p. 189-194.

Research output: Contribution to journalShort survey

Von Roretz, Christopher ; Gallouzi, Imed. / Decoding ARE-mediated decay : Is microRNA part of the equation?. In: Journal of Cell Biology. 2008 ; Vol. 181, No. 2. pp. 189-194.
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