Declining Transplantability of Prospective Kidney Transplant Recipients

Jhoong S. Cheigh, Marilena Fotino, William T. Stubenbord, Manikkam Suthanthiran, Robert R. Riggio, Stuart D. Saal

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The total number of cadaveric kidney transplants has been declining, despite an increasing dialysis population, greater understanding of transplant immunology, and improved transplant management. To explore the causes of this decline, various factors were studied in 140 dialysis patients who were awaiting transplantation and 100 consecutive recipients of cadaveric kidney transplants. The study indicates that there is a growing, now predominant, prospective kidney recipient population that is highly sensitized because of previous blood transfusions and kidney transplantations. As a result, 92% of the prospective recipients exhibit varying degrees of lymphocytotoxic antibodies. Thus, a major problem in clinical transplantation is the growing number of dialysis patients who are virtually untransplantable. The declining number of cadaveric kidney transplantations may be caused by, in part, changing immunologic characteristics in the recipient population.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume246
Issue number2
DOIs
Publication statusPublished - 10 Jul 1981
Externally publishedYes

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Transplants
Kidney
Dialysis
Kidney Transplantation
Transplantation
Population
Antilymphocyte Serum
Allergy and Immunology
Blood Transfusion
Transplant Recipients

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Declining Transplantability of Prospective Kidney Transplant Recipients. / Cheigh, Jhoong S.; Fotino, Marilena; Stubenbord, William T.; Suthanthiran, Manikkam; Riggio, Robert R.; Saal, Stuart D.

In: JAMA: The Journal of the American Medical Association, Vol. 246, No. 2, 10.07.1981, p. 135-139.

Research output: Contribution to journalArticle

Cheigh, Jhoong S. ; Fotino, Marilena ; Stubenbord, William T. ; Suthanthiran, Manikkam ; Riggio, Robert R. ; Saal, Stuart D. / Declining Transplantability of Prospective Kidney Transplant Recipients. In: JAMA: The Journal of the American Medical Association. 1981 ; Vol. 246, No. 2. pp. 135-139.
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