Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome

Elizaveta Nikitskaya, Anna Lebedeva, Oxana Ivanova, Elena Maryukhnich, Alexander Shpektor, Jean-Charles B. Grivel, Leonid Margolis, Elena Vasilieva

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Although an association between human herpesvirus (HHV) infection and atherosclerosis has been suggested, the data supporting such an association are controversial and, in most cases, are based on serological evidence or on the presence of cell-associated HHV DNA, which do not report about actual viral replication. We quantified the DNA of all 8 types of HHVs in plasma, in which their presence is evidence of viral replication. Methods and Results: Using quantitative real-time polymerase chain reaction, we evaluated the presence of HHV DNA in blood samples obtained at the time of hospitalization from 71 patients with acute coronary syndrome, 26 patients with stable coronary artery disease, and 53 healthy volunteers and in atherosclerotic plaques of 22 patients with peripheral artery disease who underwent endarterectomy. HHV-5 (cytomegalovirus [CMV]) was the only HHV with a level that was higher in acute coronary syndrome patients than in the control group and that correlated with the level of high-sensitivity C-reactive protein. The numbers of effector memory T cells positively correlated with the numbers of CMV genome copies in carotid arteries plaques, whereas the numbers of central memory T cells negatively correlated with CMV copy numbers. Conclusions: Of all HHV levels, only CMV was higher in patients with stable coronary artery disease and acute coronary syndrome than in the healthy group, and its load correlated with the level of high-sensitivity C-reactive protein. The level of CMV in atherosclerotic plaques correlated with the state of immunoactivation of lymphocytes in plaques, suggesting that the reactivation of CMV may contribute to the immune activation associated with the progression of atherosclerosis.

Original languageEnglish
Article numbere003759
JournalJournal of the American Heart Association
Volume5
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016

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Cytomegalovirus Infections
Acute Coronary Syndrome
Cytomegalovirus
Herpesviridae
Atherosclerotic Plaques
C-Reactive Protein
Coronary Artery Disease
DNA
Atherosclerosis
T-Lymphocytes
Herpesviridae Infections
Human Herpesvirus 8
Endarterectomy
Carotid Stenosis
Peripheral Arterial Disease
Real-Time Polymerase Chain Reaction
Healthy Volunteers
Hospitalization
Genome
Lymphocytes

Keywords

  • Acute coronary syndrome
  • Atherosclerosis
  • Human herpesvirus
  • Immune system
  • Myocardial infarction
  • Polymerase chain reaction
  • Virus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nikitskaya, E., Lebedeva, A., Ivanova, O., Maryukhnich, E., Shpektor, A., Grivel, J-C. B., ... Vasilieva, E. (2016). Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome. Journal of the American Heart Association, 5(8), [e003759]. https://doi.org/10.1161/JAHA.116.003759

Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome. / Nikitskaya, Elizaveta; Lebedeva, Anna; Ivanova, Oxana; Maryukhnich, Elena; Shpektor, Alexander; Grivel, Jean-Charles B.; Margolis, Leonid; Vasilieva, Elena.

In: Journal of the American Heart Association, Vol. 5, No. 8, e003759, 01.08.2016.

Research output: Contribution to journalArticle

Nikitskaya, E, Lebedeva, A, Ivanova, O, Maryukhnich, E, Shpektor, A, Grivel, J-CB, Margolis, L & Vasilieva, E 2016, 'Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome', Journal of the American Heart Association, vol. 5, no. 8, e003759. https://doi.org/10.1161/JAHA.116.003759
Nikitskaya, Elizaveta ; Lebedeva, Anna ; Ivanova, Oxana ; Maryukhnich, Elena ; Shpektor, Alexander ; Grivel, Jean-Charles B. ; Margolis, Leonid ; Vasilieva, Elena. / Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome. In: Journal of the American Heart Association. 2016 ; Vol. 5, No. 8.
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