Cytokine mRNA expressions in symptomatic vs. asymptomatic amoebiasis patients

D. Bansal, R. Sehgal, Y. Chawla, N. Malla, R. C. Mahajan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Infection with Entamoeba histolytica results in high mortality worldwide. Studies on the cytokine response in symptomatic and asymptomatic amoebiasis (caused by E. histolytica, the pathogenic species and E. dispar, the non-pathogenic species) subjects and their correlation with symptomatology are lacking. The present study reports the cytokine response (TNF-α, IFN-γ, IL-4, IL-10 and TGF-β) in such subjects as measured by RT-PCR. The results showed significantly (< 0.05) higher expressions of IL-10 and TGF-β in the symptomatic group as compared to the asymptomatic and healthy controls. The cytokine profile indicated the role of suppressive immune response in symptomatic amoebiasis patients.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalParasite Immunology
Volume27
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 2005

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Keywords

  • Cytokines
  • Suppression
  • Symptomatic/asymptomatic amoebiasis
  • Th1/Th2/Th3
  • mRNA expression

ASJC Scopus subject areas

  • Parasitology
  • Immunology

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