Cyclosporine-induced remission of relapsing nephrotic syndrome in children

Amir Tejani, K. halid Butt, H. oward Trachtman, Manikkam Suthanthiran, C. J. Rosenthal, M. R. Khawar

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Abstract

We treated 20 steroid-resistant or steroid-dependent nephrotic patients with oral cyclosporine for 8 weeks; they had been treated previously with cyclophosphamide or chlorambucil. Cyclosporine was started at 7 mg/kg/d and titrated to maintain a serum level of 100 to 200 ng/mL. Of 20 patients, 14 had a complete remission and the remaining six had a reduction in their proteinuria. By life table analysis, 40% of the responders show a sustained remission of up to a year. Pretherapy levels of interleukin 2, measured in 10 patients, were normal or supranormal in eight, six of whom were treatment responders; two patients with low levels of interleukin 2 were both nonresponders. Cyclosporine can be used to induce a remission in relapsing nephrotic patients, and short-term cyclosporine therapy does not produce nephrotoxic effects.

Original languageEnglish
Pages (from-to)1056-1062
Number of pages7
JournalThe Journal of Pediatrics
Volume111
Issue number6 PART 2
DOIs
Publication statusPublished - 1 Jan 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Tejani, A., Butt, K. H., Trachtman, H. O., Suthanthiran, M., Rosenthal, C. J., & Khawar, M. R. (1987). Cyclosporine-induced remission of relapsing nephrotic syndrome in children. The Journal of Pediatrics, 111(6 PART 2), 1056-1062. https://doi.org/10.1016/S0022-3476(87)80056-2