Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract

T. Ozaki, S. I. Rennard, Ronald Crystal

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cyclooxygenase metabolites of arachidonic acid are thought to play an important role in the regulation of diverse physiological functions in the lung. Although the concentration of these metabolites required to have effects is several orders of magnitude greater than the concentration of these mediators in the blood, it has been postulated that local concentrations within tissues are much higher. In a direct test of this hypothesis, the concentrations of the cyclooxygenase products of arachidonic acid including prostaglandin (PG) E, PGF(2α), 6-keto-PGF(1α), and thromboxane B2, were measured in a specialized tissue compartment, the epithelial surface of the lower respiratory tract. The concentration of these mediators within this compartment was 50- to 80-fold greater than concurrent blood levels and are sufficient to likely have physiological effects. Thus the epithelial surface of the lower respiratory tract represents a specialized compartment with high local levels of cyclooxygenase products of arachidonic acid.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalJournal of Applied Physiology
Volume62
Issue number1
Publication statusPublished - 1 Jan 1987
Externally publishedYes

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Prostaglandin-Endoperoxide Synthases
Respiratory System
Prostaglandins F
Thromboxane B2
Prostaglandins E
Epithelium
Lung

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract. / Ozaki, T.; Rennard, S. I.; Crystal, Ronald.

In: Journal of Applied Physiology, Vol. 62, No. 1, 01.01.1987, p. 219-222.

Research output: Contribution to journalArticle

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