CXCR4-Tropic HIV-1 Suppresses Replication of CCR5-Tropic HIV-1 in Human Lymphoid Tissue by Selective Induction of CC-Chemokines

Yoshinori Ito, Jean-Charles B. Grivel, Silvia Chen, Yana Kiselyeva, Patricia Reichelderfer, Leonid Margolis

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In infected individuals, human immunodeficiency virus type 1 (HIV-1) exist as a "swarm" of quasi species compartmentalized in tissues where individual viral variants may interact locally. We have used human lymphoid tissue, where the critical events of HIV disease occur, to study local interactions in model HIV-1 binary swarms ex vivo. We infected tissue blocks with binary mixtures consisting either of CCR5-dependent and CXCR4-dependent variants or of 2 dual-tropic HIV-1 variants, of which one is skewed to utilization of CXCR4 and the other of CCR5. HIV-1 variants that use CXCR4 suppress replication of CCR5-dependent HIV-1 variants, whereas CCR5-dependent HIV-1 variants do not affect replication of CXCR4-dependent HIV-1. CC-chemokines that inhibit replication of CCR5-dependent HIV-1 variants were up-regulated by CXCR4-dependent HIV-1, thus possibly contributing to this suppression. Tissue-specific chemokine/cytokine network modulations triggered by individual HIV-1 variants may be an important mechanism of local interactions among HIV-1 quasi species in infected tissue.

Original languageEnglish
Pages (from-to)506-514
Number of pages9
JournalJournal of Infectious Diseases
Volume189
Issue number3
DOIs
Publication statusPublished - 1 Feb 2004
Externally publishedYes

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CC Chemokines
Lymphoid Tissue
HIV-1
Chemokines
HIV

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

CXCR4-Tropic HIV-1 Suppresses Replication of CCR5-Tropic HIV-1 in Human Lymphoid Tissue by Selective Induction of CC-Chemokines. / Ito, Yoshinori; Grivel, Jean-Charles B.; Chen, Silvia; Kiselyeva, Yana; Reichelderfer, Patricia; Margolis, Leonid.

In: Journal of Infectious Diseases, Vol. 189, No. 3, 01.02.2004, p. 506-514.

Research output: Contribution to journalArticle

Ito, Yoshinori ; Grivel, Jean-Charles B. ; Chen, Silvia ; Kiselyeva, Yana ; Reichelderfer, Patricia ; Margolis, Leonid. / CXCR4-Tropic HIV-1 Suppresses Replication of CCR5-Tropic HIV-1 in Human Lymphoid Tissue by Selective Induction of CC-Chemokines. In: Journal of Infectious Diseases. 2004 ; Vol. 189, No. 3. pp. 506-514.
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