CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies

S. Nishino, T. Kanbayashi, N. Fujiki, M. Uchino, B. Ripley, M. Watanabe, G. J. Lammers, H. Ishiguro, S. Shoji, Y. Nishida, S. Overeem, I. Toyoshima, Y. Yoshida, T. Shimizu, S. Taheri, E. Mignot

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Abstract

CSF hypocretin-1 was measured in 28 Guillain-Barré syndrome (GBS), 12 Miller-Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects. Seven GBS subjects had undetectably low hypocretin-1 levels (<100 pg/mL). Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities.

Original languageEnglish
Pages (from-to)823-825
Number of pages3
JournalNeurology
Volume61
Issue number6
DOIs
Publication statusPublished - 23 Sep 2003

ASJC Scopus subject areas

  • Clinical Neurology

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    Nishino, S., Kanbayashi, T., Fujiki, N., Uchino, M., Ripley, B., Watanabe, M., Lammers, G. J., Ishiguro, H., Shoji, S., Nishida, Y., Overeem, S., Toyoshima, I., Yoshida, Y., Shimizu, T., Taheri, S., & Mignot, E. (2003). CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies. Neurology, 61(6), 823-825. https://doi.org/10.1212/01.WNL.0000081049.14098.50