Cross-sectional associations between air pollution and chronic bronchitis

An ESCAPE meta-analysis across five cohorts

Yutong Cai, Tamara Schikowski, Martin Adam, Anna Buschka, Anne Elie Carsin, Benedicte Jacquemin, Alessandro Marcon, Margaux Sanchez, Andrea Vierkötter, Zeinab Al Kanaani, Rob Beelen, Matthias Birk, Bert Brunekreef, Marta Cirach, Franc¸oise Clavel-Chapelon, Christophe Declercq, Kees De Hoogh, Audrey De Nazelle, Regina E. Ducret-Stich, Virginia Valeria Ferretti & 23 others Bertil Forsberg, Margaret W. Gerbase, Rebecca Hardy, Joachim Heinrich, Gerard Hoek, Debbie Jarvis, Dirk Keidel, Diana Kuh, Mark J. Nieuwenhuijsen, Martina S. Ragettli, Andrea Ranzi, Thierry Rochat, Christian Schindler, Dorothea Sugiri, Sofia Temam, Ming Yi Tsai, Raphaëlle Varraso, Francine Kauffmann, Ursula Krämer, Jordi Sunyer, Nino Künzli, Nicole Probst-Hensch, Anna L. Hansell

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in fi ve cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project. Methods: Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008-2011 were assigned to home address at most recent assessments (1998-2011). Symptoms examined were chronic bronchitis (cough and phlegm for ≥3 months of the year for ≥2 years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-speci fic cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis. Results: 15 279 and 10 537 participants respectively were included in the main NO2and PM analyses at assessments in 1998-2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2and PM10for assessments in 1985-2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarseOR 1.31 (1.05 to 1.64) per 5 μg/m3increase and PM10with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs(black carbon) exposures. Conclusions: Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.

Original languageEnglish
Pages (from-to)1005-1014
Number of pages10
JournalThorax
Volume69
Issue number11
DOIs
Publication statusPublished - 1 Nov 2014
Externally publishedYes

Fingerprint

Chronic Bronchitis
Air Pollution
Cough
Meta-Analysis
Cohort Studies
Soot
Nitrogen Dioxide
Air Pollutants
Particulate Matter
Asthma
Logistic Models
Smoking
Regression Analysis
Interviews
Education
Population

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Cai, Y., Schikowski, T., Adam, M., Buschka, A., Carsin, A. E., Jacquemin, B., ... Hansell, A. L. (2014). Cross-sectional associations between air pollution and chronic bronchitis: An ESCAPE meta-analysis across five cohorts. Thorax, 69(11), 1005-1014. https://doi.org/10.1136/thoraxjnl-2013-204352

Cross-sectional associations between air pollution and chronic bronchitis : An ESCAPE meta-analysis across five cohorts. / Cai, Yutong; Schikowski, Tamara; Adam, Martin; Buschka, Anna; Carsin, Anne Elie; Jacquemin, Benedicte; Marcon, Alessandro; Sanchez, Margaux; Vierkötter, Andrea; Al Kanaani, Zeinab; Beelen, Rob; Birk, Matthias; Brunekreef, Bert; Cirach, Marta; Clavel-Chapelon, Franc¸oise; Declercq, Christophe; De Hoogh, Kees; De Nazelle, Audrey; Ducret-Stich, Regina E.; Ferretti, Virginia Valeria; Forsberg, Bertil; Gerbase, Margaret W.; Hardy, Rebecca; Heinrich, Joachim; Hoek, Gerard; Jarvis, Debbie; Keidel, Dirk; Kuh, Diana; Nieuwenhuijsen, Mark J.; Ragettli, Martina S.; Ranzi, Andrea; Rochat, Thierry; Schindler, Christian; Sugiri, Dorothea; Temam, Sofia; Tsai, Ming Yi; Varraso, Raphaëlle; Kauffmann, Francine; Krämer, Ursula; Sunyer, Jordi; Künzli, Nino; Probst-Hensch, Nicole; Hansell, Anna L.

In: Thorax, Vol. 69, No. 11, 01.11.2014, p. 1005-1014.

Research output: Contribution to journalArticle

Cai, Y, Schikowski, T, Adam, M, Buschka, A, Carsin, AE, Jacquemin, B, Marcon, A, Sanchez, M, Vierkötter, A, Al Kanaani, Z, Beelen, R, Birk, M, Brunekreef, B, Cirach, M, Clavel-Chapelon, F, Declercq, C, De Hoogh, K, De Nazelle, A, Ducret-Stich, RE, Ferretti, VV, Forsberg, B, Gerbase, MW, Hardy, R, Heinrich, J, Hoek, G, Jarvis, D, Keidel, D, Kuh, D, Nieuwenhuijsen, MJ, Ragettli, MS, Ranzi, A, Rochat, T, Schindler, C, Sugiri, D, Temam, S, Tsai, MY, Varraso, R, Kauffmann, F, Krämer, U, Sunyer, J, Künzli, N, Probst-Hensch, N & Hansell, AL 2014, 'Cross-sectional associations between air pollution and chronic bronchitis: An ESCAPE meta-analysis across five cohorts', Thorax, vol. 69, no. 11, pp. 1005-1014. https://doi.org/10.1136/thoraxjnl-2013-204352
Cai, Yutong ; Schikowski, Tamara ; Adam, Martin ; Buschka, Anna ; Carsin, Anne Elie ; Jacquemin, Benedicte ; Marcon, Alessandro ; Sanchez, Margaux ; Vierkötter, Andrea ; Al Kanaani, Zeinab ; Beelen, Rob ; Birk, Matthias ; Brunekreef, Bert ; Cirach, Marta ; Clavel-Chapelon, Franc¸oise ; Declercq, Christophe ; De Hoogh, Kees ; De Nazelle, Audrey ; Ducret-Stich, Regina E. ; Ferretti, Virginia Valeria ; Forsberg, Bertil ; Gerbase, Margaret W. ; Hardy, Rebecca ; Heinrich, Joachim ; Hoek, Gerard ; Jarvis, Debbie ; Keidel, Dirk ; Kuh, Diana ; Nieuwenhuijsen, Mark J. ; Ragettli, Martina S. ; Ranzi, Andrea ; Rochat, Thierry ; Schindler, Christian ; Sugiri, Dorothea ; Temam, Sofia ; Tsai, Ming Yi ; Varraso, Raphaëlle ; Kauffmann, Francine ; Krämer, Ursula ; Sunyer, Jordi ; Künzli, Nino ; Probst-Hensch, Nicole ; Hansell, Anna L. / Cross-sectional associations between air pollution and chronic bronchitis : An ESCAPE meta-analysis across five cohorts. In: Thorax. 2014 ; Vol. 69, No. 11. pp. 1005-1014.
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abstract = "Background: This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in fi ve cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project. Methods: Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008-2011 were assigned to home address at most recent assessments (1998-2011). Symptoms examined were chronic bronchitis (cough and phlegm for ≥3 months of the year for ≥2 years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-speci fic cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis. Results: 15 279 and 10 537 participants respectively were included in the main NO2and PM analyses at assessments in 1998-2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2and PM10for assessments in 1985-2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarseOR 1.31 (1.05 to 1.64) per 5 μg/m3increase and PM10with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs(black carbon) exposures. Conclusions: Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.",
author = "Yutong Cai and Tamara Schikowski and Martin Adam and Anna Buschka and Carsin, {Anne Elie} and Benedicte Jacquemin and Alessandro Marcon and Margaux Sanchez and Andrea Vierk{\"o}tter and {Al Kanaani}, Zeinab and Rob Beelen and Matthias Birk and Bert Brunekreef and Marta Cirach and Franc¸oise Clavel-Chapelon and Christophe Declercq and {De Hoogh}, Kees and {De Nazelle}, Audrey and Ducret-Stich, {Regina E.} and Ferretti, {Virginia Valeria} and Bertil Forsberg and Gerbase, {Margaret W.} and Rebecca Hardy and Joachim Heinrich and Gerard Hoek and Debbie Jarvis and Dirk Keidel and Diana Kuh and Nieuwenhuijsen, {Mark J.} and Ragettli, {Martina S.} and Andrea Ranzi and Thierry Rochat and Christian Schindler and Dorothea Sugiri and Sofia Temam and Tsai, {Ming Yi} and Rapha{\"e}lle Varraso and Francine Kauffmann and Ursula Kr{\"a}mer and Jordi Sunyer and Nino K{\"u}nzli and Nicole Probst-Hensch and Hansell, {Anna L.}",
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TY - JOUR

T1 - Cross-sectional associations between air pollution and chronic bronchitis

T2 - An ESCAPE meta-analysis across five cohorts

AU - Cai, Yutong

AU - Schikowski, Tamara

AU - Adam, Martin

AU - Buschka, Anna

AU - Carsin, Anne Elie

AU - Jacquemin, Benedicte

AU - Marcon, Alessandro

AU - Sanchez, Margaux

AU - Vierkötter, Andrea

AU - Al Kanaani, Zeinab

AU - Beelen, Rob

AU - Birk, Matthias

AU - Brunekreef, Bert

AU - Cirach, Marta

AU - Clavel-Chapelon, Franc¸oise

AU - Declercq, Christophe

AU - De Hoogh, Kees

AU - De Nazelle, Audrey

AU - Ducret-Stich, Regina E.

AU - Ferretti, Virginia Valeria

AU - Forsberg, Bertil

AU - Gerbase, Margaret W.

AU - Hardy, Rebecca

AU - Heinrich, Joachim

AU - Hoek, Gerard

AU - Jarvis, Debbie

AU - Keidel, Dirk

AU - Kuh, Diana

AU - Nieuwenhuijsen, Mark J.

AU - Ragettli, Martina S.

AU - Ranzi, Andrea

AU - Rochat, Thierry

AU - Schindler, Christian

AU - Sugiri, Dorothea

AU - Temam, Sofia

AU - Tsai, Ming Yi

AU - Varraso, Raphaëlle

AU - Kauffmann, Francine

AU - Krämer, Ursula

AU - Sunyer, Jordi

AU - Künzli, Nino

AU - Probst-Hensch, Nicole

AU - Hansell, Anna L.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Background: This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in fi ve cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project. Methods: Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008-2011 were assigned to home address at most recent assessments (1998-2011). Symptoms examined were chronic bronchitis (cough and phlegm for ≥3 months of the year for ≥2 years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-speci fic cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis. Results: 15 279 and 10 537 participants respectively were included in the main NO2and PM analyses at assessments in 1998-2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2and PM10for assessments in 1985-2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarseOR 1.31 (1.05 to 1.64) per 5 μg/m3increase and PM10with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs(black carbon) exposures. Conclusions: Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.

AB - Background: This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in fi ve cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project. Methods: Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008-2011 were assigned to home address at most recent assessments (1998-2011). Symptoms examined were chronic bronchitis (cough and phlegm for ≥3 months of the year for ≥2 years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-speci fic cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis. Results: 15 279 and 10 537 participants respectively were included in the main NO2and PM analyses at assessments in 1998-2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2and PM10for assessments in 1985-2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarseOR 1.31 (1.05 to 1.64) per 5 μg/m3increase and PM10with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs(black carbon) exposures. Conclusions: Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.

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