Cross-ontological analytics: Combining associative and hierarchical relations in the gene ontologies to assess gene product similarity

C. Posse, A. Sanfilippo, B. Gopalan, R. Riensche, N. Beagley, B. Baddeley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Gene and gene product similarity is a fundamental diagnostic measure in analyzing biological data and constructing predictive models for functional genomics. With the rising influence of the gene ontologies, two complementary approaches have emerged where the similarity between two genes/gene products is obtained by comparing gene ontology (GO) annotations associated with the gene/gene products. One approach captures GO-based similarity in terms of hierarchical relations within each gene ontology. The other approach identifies GO-based similarity in terms of associative relations across the three gene ontologies. We propose a novel methodology where the two approaches can be merged with ensuing benefits in coverage and accuracy.

Original languageEnglish
Title of host publicationComputational Science - ICCS 2006
Subtitle of host publication6th International Conference, Proceedings
PublisherSpringer Verlag
Pages871-878
Number of pages8
ISBN (Print)3540343814, 9783540343813
DOIs
Publication statusPublished - 1 Jan 2006
EventICCS 2006: 6th International Conference on Computational Science - Reading, United Kingdom
Duration: 28 May 200631 May 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3992 LNCS - II
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

ConferenceICCS 2006: 6th International Conference on Computational Science
CountryUnited Kingdom
CityReading
Period28/5/0631/5/06

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ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Posse, C., Sanfilippo, A., Gopalan, B., Riensche, R., Beagley, N., & Baddeley, B. (2006). Cross-ontological analytics: Combining associative and hierarchical relations in the gene ontologies to assess gene product similarity. In Computational Science - ICCS 2006: 6th International Conference, Proceedings (pp. 871-878). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 3992 LNCS - II). Springer Verlag. https://doi.org/10.1007/11758525_116