Creatine kinase is a marker of metabolic syndrome in qatari women with and without polycystic ovarian syndrome

Noora Al-Hail, Alexandra E. Butler, Soha Dargham, Ahmed Abou Seif, Stephen Atkin

Research output: Contribution to journalArticle

Abstract

Objective: To correlate features of metabolic syndrome with creatine kinase (CK) in women with and without polycystic ovary syndrome (PCOS). Design: Comparative cross-sectional analysis. Methods: Demographic and metabolic data from Qatari women aged 18–40 years from the Qatar Biobank (97 diagnosed with PCOS, 563 controls). The primary outcome was the association between plasma CK and features of metabolic syndrome. Results: CK increased when the waist circumference was >80 cm (p < 0.015) and when associated with 2 or more features of the metabolic syndrome (p < 0.01). CK correlated with BMI (p < 0.003) but not with waist/hip ratio. Overall, CK did not differ between PCOS and controls, rising equally in both as body mass index (BMI) increased. C reactive protein (CRP) was higher in obese PCOS (P < 0.05) compared to controls, but did not correlate with CK (p > 0.05). Conclusion: CK was associated with an increase in BMI, waist circumference >80 cm and 2 or more features of the metabolic syndrome, in accord with the central role of type II skeletal muscle fibers in energy metabolism and obesity. CK was, however, independent of the PCOS phenotype.

Original languageEnglish
Article number659
JournalFrontiers in Endocrinology
Volume10
Issue numberSEP
DOIs
Publication statusPublished - 1 Sep 2019

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Polycystic Ovary Syndrome
Creatine Kinase
Waist Circumference
Qatar
Fast-Twitch Muscle Fibers
Skeletal Muscle Fibers
Energy Metabolism
Obesity
Cross-Sectional Studies
Demography
Phenotype

Keywords

  • Creatine kinase
  • Inflammation
  • Metabolic syndrome
  • Obesity
  • Polycystic ovarian syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Creatine kinase is a marker of metabolic syndrome in qatari women with and without polycystic ovarian syndrome. / Al-Hail, Noora; Butler, Alexandra E.; Dargham, Soha; Seif, Ahmed Abou; Atkin, Stephen.

In: Frontiers in Endocrinology, Vol. 10, No. SEP, 659, 01.09.2019.

Research output: Contribution to journalArticle

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