COX-2 gene polymorphisms and risk of chronic periodontitis

A case-control study and meta-analysis

G. Prakash, Meenakshi Umar, S. Ajay, D. Bali, R. Upadhyay, K. K. Gupta, J. Dixit, B. Mittal

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Cyclooxygenase-2 (COX-2) enzyme is a major mediator of inflammation in periodontitis, leading to loss of gingival tissues and alveolar bone supporting the teeth. Previous studies have explored the role of COX-2 polymorphisms with the risk of periodontitis in different ethnic groups; however, findings are inconsistent. So, we aimed to investigate the association of COX-2 polymorphisms (rs20417, rs689466, and rs5275) in susceptibility to chronic periodontitis (CP) in northern Indian population. Meta-analysis was also carried out to precisely estimate the effect of COX-2 polymorphisms in CP. Materials and Methods: Genotyping of COX-2 polymorphisms was carried out through PCR-RFLP in 200 CP cases and 200 controls. For risk estimation, binary logistic regression was applied using SPSS, version 15.0, while meta-analysis was carried using MIX 2.0 software. Results: None of the COX-2 polymorphisms independently were associated with the risk of CP. Meta-analysis suggested a significant reduced risk of CP with rs5275+8473 C allele and rs20417 in Chinese population. Conclusions: No association was observed in any of the studied COX-2 polymorphisms with CP in North India. But, the study should be replicated in larger sample size to arrive at a definitive conclusion. Meta-analysis suggested a role of rs5275 COX-2 polymorphisms in susceptibility to overall CP, and on ethnic basis, rs20417 showed reduced risk of CP in Chinese population.

Original languageEnglish
Pages (from-to)38-45
Number of pages8
JournalOral Diseases
Volume21
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Fingerprint

Chronic Periodontitis
Cyclooxygenase 2
Meta-Analysis
Case-Control Studies
Genes
Periodontitis
Population
Inflammation Mediators
Ethnic Groups
Restriction Fragment Length Polymorphisms
Sample Size
India
Tooth
Software
Logistic Models
Alleles
Bone and Bones
Polymerase Chain Reaction
Enzymes

Keywords

  • Cyclooxygenase-2
  • Meta-analysis
  • Periodontitis
  • Susceptibility

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

COX-2 gene polymorphisms and risk of chronic periodontitis : A case-control study and meta-analysis. / Prakash, G.; Umar, Meenakshi; Ajay, S.; Bali, D.; Upadhyay, R.; Gupta, K. K.; Dixit, J.; Mittal, B.

In: Oral Diseases, Vol. 21, No. 1, 01.01.2015, p. 38-45.

Research output: Contribution to journalArticle

Prakash, G, Umar, M, Ajay, S, Bali, D, Upadhyay, R, Gupta, KK, Dixit, J & Mittal, B 2015, 'COX-2 gene polymorphisms and risk of chronic periodontitis: A case-control study and meta-analysis', Oral Diseases, vol. 21, no. 1, pp. 38-45. https://doi.org/10.1111/odi.12203
Prakash, G. ; Umar, Meenakshi ; Ajay, S. ; Bali, D. ; Upadhyay, R. ; Gupta, K. K. ; Dixit, J. ; Mittal, B. / COX-2 gene polymorphisms and risk of chronic periodontitis : A case-control study and meta-analysis. In: Oral Diseases. 2015 ; Vol. 21, No. 1. pp. 38-45.
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AB - Objective: Cyclooxygenase-2 (COX-2) enzyme is a major mediator of inflammation in periodontitis, leading to loss of gingival tissues and alveolar bone supporting the teeth. Previous studies have explored the role of COX-2 polymorphisms with the risk of periodontitis in different ethnic groups; however, findings are inconsistent. So, we aimed to investigate the association of COX-2 polymorphisms (rs20417, rs689466, and rs5275) in susceptibility to chronic periodontitis (CP) in northern Indian population. Meta-analysis was also carried out to precisely estimate the effect of COX-2 polymorphisms in CP. Materials and Methods: Genotyping of COX-2 polymorphisms was carried out through PCR-RFLP in 200 CP cases and 200 controls. For risk estimation, binary logistic regression was applied using SPSS, version 15.0, while meta-analysis was carried using MIX 2.0 software. Results: None of the COX-2 polymorphisms independently were associated with the risk of CP. Meta-analysis suggested a significant reduced risk of CP with rs5275+8473 C allele and rs20417 in Chinese population. Conclusions: No association was observed in any of the studied COX-2 polymorphisms with CP in North India. But, the study should be replicated in larger sample size to arrive at a definitive conclusion. Meta-analysis suggested a role of rs5275 COX-2 polymorphisms in susceptibility to overall CP, and on ethnic basis, rs20417 showed reduced risk of CP in Chinese population.

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