COX-2 gene polymorphisms and risk of chronic periodontitis: A case-control study and meta-analysis

G. Prakash, Meenakshi Umar, S. Ajay, D. Bali, R. Upadhyay, K. K. Gupta, J. Dixit, B. Mittal

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7 Citations (Scopus)


Objective: Cyclooxygenase-2 (COX-2) enzyme is a major mediator of inflammation in periodontitis, leading to loss of gingival tissues and alveolar bone supporting the teeth. Previous studies have explored the role of COX-2 polymorphisms with the risk of periodontitis in different ethnic groups; however, findings are inconsistent. So, we aimed to investigate the association of COX-2 polymorphisms (rs20417, rs689466, and rs5275) in susceptibility to chronic periodontitis (CP) in northern Indian population. Meta-analysis was also carried out to precisely estimate the effect of COX-2 polymorphisms in CP. Materials and Methods: Genotyping of COX-2 polymorphisms was carried out through PCR-RFLP in 200 CP cases and 200 controls. For risk estimation, binary logistic regression was applied using SPSS, version 15.0, while meta-analysis was carried using MIX 2.0 software. Results: None of the COX-2 polymorphisms independently were associated with the risk of CP. Meta-analysis suggested a significant reduced risk of CP with rs5275+8473 C allele and rs20417 in Chinese population. Conclusions: No association was observed in any of the studied COX-2 polymorphisms with CP in North India. But, the study should be replicated in larger sample size to arrive at a definitive conclusion. Meta-analysis suggested a role of rs5275 COX-2 polymorphisms in susceptibility to overall CP, and on ethnic basis, rs20417 showed reduced risk of CP in Chinese population.

Original languageEnglish
Pages (from-to)38-45
Number of pages8
JournalOral Diseases
Issue number1
Publication statusPublished - 1 Jan 2015
Externally publishedYes



  • Cyclooxygenase-2
  • Meta-analysis
  • Periodontitis
  • Susceptibility

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Prakash, G., Umar, M., Ajay, S., Bali, D., Upadhyay, R., Gupta, K. K., Dixit, J., & Mittal, B. (2015). COX-2 gene polymorphisms and risk of chronic periodontitis: A case-control study and meta-analysis. Oral Diseases, 21(1), 38-45.