Covalent grafting of the RGD-peptide onto polyetheretherketone surfaces via schiff base formation

Marc Becker, Steffen Lorenz, Dennis Strand, Christian Friedrich Vahl, Matthias Gabriel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In recent years, the synthetic polymer polyetheretherketone (PEEK) has increasingly been used in a number of orthopedic implementations, due to its excellent mechanical properties, bioinertness, and chemical resistance. For in vivo applications, the surface of PEEK, which does not naturally support cell adhesion, has to be modified to improve tissue integration. In the present work we demonstrate a novel wet-chemical modification of PEEK to modify the surface, enabling the covalent grafting of the cell-adhesive RGD-peptide. Modification of the polymer surface was achieved via Schiff base formation using an aliphatic diamine and subsequent crosslinker-mediated immobilization of the peptide. In cell culture experiments with primary osteoblasts it was shown that the RGD-modified PEEK not only significantly promoted cellular adhesion but also strongly enhanced the proliferation of osteoblasts on the modified polymer surface.

Original languageEnglish
Article number616535
JournalThe Scientific World Journal
Volume2013
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Schiff Bases
peptide
Polymers
polymer
Osteoblasts
adhesion
Diamines
Chemical resistance
Cell adhesion
Chemical modification
Orthopedics
Cell culture
Cell Adhesion
Immobilization
Adhesives
immobilization
mechanical property
Adhesion
Cell Culture Techniques
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Covalent grafting of the RGD-peptide onto polyetheretherketone surfaces via schiff base formation. / Becker, Marc; Lorenz, Steffen; Strand, Dennis; Vahl, Christian Friedrich; Gabriel, Matthias.

In: The Scientific World Journal, Vol. 2013, 616535, 2013.

Research output: Contribution to journalArticle

Becker, Marc ; Lorenz, Steffen ; Strand, Dennis ; Vahl, Christian Friedrich ; Gabriel, Matthias. / Covalent grafting of the RGD-peptide onto polyetheretherketone surfaces via schiff base formation. In: The Scientific World Journal. 2013 ; Vol. 2013.
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