Corroborative assessment of mushroom as the graceful ageing and lifespan promoting agent

Azizur Rahaman, Noorlidah Abdullah, Norhaniza Aminudin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The unprecedented increase in the elderly population poses the threat of “ageing tsunami”. Thus, graceful ageing representing the healthy life span is of immense importance in the modern world. Mushrooms, harboring numerous bio-active components, appear to be a promising anti-ageing agent. Mushroom myco-components’ protective role against cellular ageing mediators, as well as those components’ supportive effects for cellular longevity; have been reviewed in this article. Among multiple strategies, the direct life span extension of model organisms (Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster) and human cell lines, along with oxidative stress attenuating, immune-modulating, anti-ageing, and anti-andropausal effects of mushrooms have been explored in this review. Assessment of edible-medicinal mushrooms with respect to their anti-ageing and lifespan promoting capabilities, stand them in ideal stead as a therapeutic agent for the global ever-mushrooming aged population.

Original languageEnglish
Pages (from-to)2072-2083
Number of pages12
JournalBiointerface Research in Applied Chemistry
Volume7
Issue number3
Publication statusPublished - 1 Jan 2017

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Keywords

  • Ageing hallmarks
  • Free radicals
  • Healthy life span
  • Immunomodulation
  • Mitochondrial decline
  • Oxidative stress

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Biochemistry
  • Biotechnology

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