Corneal sensitivity is related to established measures of diabetic peripheral neuropathy

Nicola Pritchard, Katie Edwards, Dimitrios Vagenas, Anthony W. Russell, Rayaz Malik, Nathan Efron

Research output: Contribution to journalArticle

15 Citations (Scopus)


Purpose: The objective was to investigate the association between corneal sensitivity and established measures of diabetic peripheral neuropathy (DPN). Methods: Corneal sensitivity was measured in 93 individuals with diabetes, 146 diabetic individuals without neuropathy and 61 control individuals without diabetes or neuropathy using a non-contact corneal aesthesiometer at the baseline visit of a five-year longitudinal natural history study of DPN. The correlation between corneal sensitivity and established measures of neuropathy was estimated and multi-dimensional scaling was used to represent similarities and dissimilarities between variables. Results: The corneal sensitivity threshold was significantly correlated with a majority of established measures of DPN. Correlation coefficients ranged from -0.32 to 0.26. Using multi-dimensional scaling, non-contact corneal aesthesiometry was closer to the neuropathy disability score, diabetic neuropathy symptom score and Neuropad and most dissimilar to electrophysiological parameters and quantitative sensory testing. Conclusion: Corneal sensitivity, although not strongly related, is associated with other functional measures of DPN and might provide a useful adjunct in identifying functional loss of small nerve fibre integrity.

Original languageEnglish
Pages (from-to)355-361
Number of pages7
JournalClinical and Experimental Optometry
Issue number3
Publication statusPublished - May 2012
Externally publishedYes



  • Aesthesiometry
  • Cornea
  • Corneal sensitivity
  • Diabetes
  • Diabetic neuropathy
  • Non-contact corneal aesthesiometry

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

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