Corneal confocal microscopy

ready for prime time

Ioannis N. Petropoulos, Georgios Ponirakis, Adnan Khan, Hoda Gad, Hamad Almuhannadi, Michael Brines, Anthony Cerami, Rayaz Malik

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Corneal confocal microscopy is a non-invasive ophthalmic imaging modality, which was initially used for the diagnosis and management of corneal diseases. However, over the last 20 years it has come to the forefront as a rapid, non-invasive, reiterative, cost-effective imaging biomarker for neurodegeneration. The human cornea is endowed with the densest network of sensory unmyelinated axons, anywhere in the body. A robust body of evidence shows that corneal confocal microscopy is a reliable and reproducible method to quantify corneal nerve morphology. Changes in corneal nerve morphology precede or relate to clinical manifestations of peripheral and central neurodegenerative conditions. Moreover, in clinical intervention trials, corneal nerve regeneration occurs early and predicts functional gains in trials of neuroprotection. In view of these findings, it is timely to summarise the knowledge in this area of research and to explain why the case for corneal confocal microscopy is sufficiently compelling to argue for its inclusion as a Food and Drug Administration endpoint in clinical trials of peripheral and central neurodegenerative conditions.

Original languageEnglish
JournalClinical and Experimental Optometry
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Confocal Microscopy
Clinical Trials
Corneal Diseases
Nerve Regeneration
United States Food and Drug Administration
Cornea
Axons
Biomarkers
Costs and Cost Analysis
Research
Neuroprotection

Keywords

  • central neurodegeneration
  • corneal confocal microscopy
  • peripheral neuropathy

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

Cite this

Corneal confocal microscopy : ready for prime time. / Petropoulos, Ioannis N.; Ponirakis, Georgios; Khan, Adnan; Gad, Hoda; Almuhannadi, Hamad; Brines, Michael; Cerami, Anthony; Malik, Rayaz.

In: Clinical and Experimental Optometry, 01.01.2019.

Research output: Contribution to journalReview article

@article{3b430182e6d843f2a089456a4d249935,
title = "Corneal confocal microscopy: ready for prime time",
abstract = "Corneal confocal microscopy is a non-invasive ophthalmic imaging modality, which was initially used for the diagnosis and management of corneal diseases. However, over the last 20 years it has come to the forefront as a rapid, non-invasive, reiterative, cost-effective imaging biomarker for neurodegeneration. The human cornea is endowed with the densest network of sensory unmyelinated axons, anywhere in the body. A robust body of evidence shows that corneal confocal microscopy is a reliable and reproducible method to quantify corneal nerve morphology. Changes in corneal nerve morphology precede or relate to clinical manifestations of peripheral and central neurodegenerative conditions. Moreover, in clinical intervention trials, corneal nerve regeneration occurs early and predicts functional gains in trials of neuroprotection. In view of these findings, it is timely to summarise the knowledge in this area of research and to explain why the case for corneal confocal microscopy is sufficiently compelling to argue for its inclusion as a Food and Drug Administration endpoint in clinical trials of peripheral and central neurodegenerative conditions.",
keywords = "central neurodegeneration, corneal confocal microscopy, peripheral neuropathy",
author = "Petropoulos, {Ioannis N.} and Georgios Ponirakis and Adnan Khan and Hoda Gad and Hamad Almuhannadi and Michael Brines and Anthony Cerami and Rayaz Malik",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/cxo.12887",
language = "English",
journal = "Clinical and Experimental Optometry",
issn = "0816-4622",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Corneal confocal microscopy

T2 - ready for prime time

AU - Petropoulos, Ioannis N.

AU - Ponirakis, Georgios

AU - Khan, Adnan

AU - Gad, Hoda

AU - Almuhannadi, Hamad

AU - Brines, Michael

AU - Cerami, Anthony

AU - Malik, Rayaz

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Corneal confocal microscopy is a non-invasive ophthalmic imaging modality, which was initially used for the diagnosis and management of corneal diseases. However, over the last 20 years it has come to the forefront as a rapid, non-invasive, reiterative, cost-effective imaging biomarker for neurodegeneration. The human cornea is endowed with the densest network of sensory unmyelinated axons, anywhere in the body. A robust body of evidence shows that corneal confocal microscopy is a reliable and reproducible method to quantify corneal nerve morphology. Changes in corneal nerve morphology precede or relate to clinical manifestations of peripheral and central neurodegenerative conditions. Moreover, in clinical intervention trials, corneal nerve regeneration occurs early and predicts functional gains in trials of neuroprotection. In view of these findings, it is timely to summarise the knowledge in this area of research and to explain why the case for corneal confocal microscopy is sufficiently compelling to argue for its inclusion as a Food and Drug Administration endpoint in clinical trials of peripheral and central neurodegenerative conditions.

AB - Corneal confocal microscopy is a non-invasive ophthalmic imaging modality, which was initially used for the diagnosis and management of corneal diseases. However, over the last 20 years it has come to the forefront as a rapid, non-invasive, reiterative, cost-effective imaging biomarker for neurodegeneration. The human cornea is endowed with the densest network of sensory unmyelinated axons, anywhere in the body. A robust body of evidence shows that corneal confocal microscopy is a reliable and reproducible method to quantify corneal nerve morphology. Changes in corneal nerve morphology precede or relate to clinical manifestations of peripheral and central neurodegenerative conditions. Moreover, in clinical intervention trials, corneal nerve regeneration occurs early and predicts functional gains in trials of neuroprotection. In view of these findings, it is timely to summarise the knowledge in this area of research and to explain why the case for corneal confocal microscopy is sufficiently compelling to argue for its inclusion as a Food and Drug Administration endpoint in clinical trials of peripheral and central neurodegenerative conditions.

KW - central neurodegeneration

KW - corneal confocal microscopy

KW - peripheral neuropathy

UR - http://www.scopus.com/inward/record.url?scp=85062558734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062558734&partnerID=8YFLogxK

U2 - 10.1111/cxo.12887

DO - 10.1111/cxo.12887

M3 - Review article

JO - Clinical and Experimental Optometry

JF - Clinical and Experimental Optometry

SN - 0816-4622

ER -