Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia

Odelya E. Pagovich, Mary L. Vo, Zoe Z. Zhao, Ioannis N. Petropoulos, Michelle Yuan, Buntitar Lertsuwanroj, Jessica Ciralsky, Edward Lai, Szilard Kiss, Donald J. D'Amico, Jason G. Mezey, Rayaz Malik, Ronald Crystal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Friedreich ataxia (FRDA), an autosomal recessive neurodegenerative disease caused by mutations in the gene encoding for the mitochondrial protein frataxin, is characterized by ataxia and gait instability, immobility, and eventual death. We evaluated corneal confocal microscopy (CCM) quantification of corneal nerve morphology as a novel, noninvasive, in vivo quantitative imaging biomarker for the severity of neurological manifestations in FRDA. Methods: Corneal nerve fiber density, branch density, and fiber length were quantified in individuals with FRDA (n = 23) and healthy age-matched controls (n = 14). All individuals underwent genetic testing and a detailed neurological assessment with the Scale for the Assessment and Rating of Ataxia (SARA) and Friedreich's Ataxia Rating Scale (FARS). A subset of individuals with FRDA who were ambulatory underwent quantitative gait assessment. Results: CCM demonstrated a significant reduction in nerve fiber density and length in FRDA compared to healthy controls. Importantly, CCM parameters correlated with genotype, SARA and FARS neurological scales, and linear regression modeling of CCM nerve parameter–generated equations that predict the neurologic severity of FRDA. Interpretation: Together, the data suggest that CCM quantification of corneal nerve morphology is a rapid, sensitive imaging biomarker for quantifying the severity of neurologic disease in individuals with FRDA. Ann Neurol 2018;84:893–904.

Original languageEnglish
Pages (from-to)893-904
Number of pages12
JournalAnnals of Neurology
Volume84
Issue number6
DOIs
Publication statusPublished - 1 Dec 2018

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Friedreich Ataxia
Nervous System Diseases
Confocal Microscopy
Biomarkers
Ataxia
Nerve Fibers
Gait Ataxia
Mitochondrial Proteins
Genetic Testing
Neurologic Manifestations
Gait
Neurodegenerative Diseases
Nervous System
Linear Models
Genotype
Mutation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Pagovich, O. E., Vo, M. L., Zhao, Z. Z., Petropoulos, I. N., Yuan, M., Lertsuwanroj, B., ... Crystal, R. (2018). Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia. Annals of Neurology, 84(6), 893-904. https://doi.org/10.1002/ana.25355

Corneal confocal microscopy : Neurologic disease biomarker in Friedreich ataxia. / Pagovich, Odelya E.; Vo, Mary L.; Zhao, Zoe Z.; Petropoulos, Ioannis N.; Yuan, Michelle; Lertsuwanroj, Buntitar; Ciralsky, Jessica; Lai, Edward; Kiss, Szilard; D'Amico, Donald J.; Mezey, Jason G.; Malik, Rayaz; Crystal, Ronald.

In: Annals of Neurology, Vol. 84, No. 6, 01.12.2018, p. 893-904.

Research output: Contribution to journalArticle

Pagovich, OE, Vo, ML, Zhao, ZZ, Petropoulos, IN, Yuan, M, Lertsuwanroj, B, Ciralsky, J, Lai, E, Kiss, S, D'Amico, DJ, Mezey, JG, Malik, R & Crystal, R 2018, 'Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia', Annals of Neurology, vol. 84, no. 6, pp. 893-904. https://doi.org/10.1002/ana.25355
Pagovich OE, Vo ML, Zhao ZZ, Petropoulos IN, Yuan M, Lertsuwanroj B et al. Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia. Annals of Neurology. 2018 Dec 1;84(6):893-904. https://doi.org/10.1002/ana.25355
Pagovich, Odelya E. ; Vo, Mary L. ; Zhao, Zoe Z. ; Petropoulos, Ioannis N. ; Yuan, Michelle ; Lertsuwanroj, Buntitar ; Ciralsky, Jessica ; Lai, Edward ; Kiss, Szilard ; D'Amico, Donald J. ; Mezey, Jason G. ; Malik, Rayaz ; Crystal, Ronald. / Corneal confocal microscopy : Neurologic disease biomarker in Friedreich ataxia. In: Annals of Neurology. 2018 ; Vol. 84, No. 6. pp. 893-904.
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