Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria

Ioannis N. Petropoulos, Patrick Green, Agnes W.S. Chan, Uazman Alam, Hassan Fadavi, Andrew Marshall, Omar Asghar, Nathan Efron, Mitra Tavakoli, Rayaz Malik

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective Corneal innervation is increasingly used as a surrogate marker of human diabetic peripheral neuropathy (DPN) however its temporal relationship with the other microvascular complications of diabetes is not fully established. In this cross-sectional, observational study we aimed to assess whether neuropathy occurred in patients with type 1 diabetes, without retinopathy or microalbuminuria. Materials and Methods All participants underwent detailed assessment of peripheral neuropathy [neuropathy disability score (NDS), vibration perception threshold (VPT), peroneal motor nerve conduction velocity (PMNCV), sural sensory nerve conduction velocity (SSNCV) and in vivo corneal confocal microscopy (IVCCM)], retinopathy (digital fundus photography) and albuminuria status [albumin: creatinine ratio (ACR)]. Results 53 patients with Type 1 diabetes with (n=37) and without retinopathy (n=16) were compared to control subjects (n=27). SSNCV, corneal nerve fibre (CNFD) and branch (CNBD) density and length (CNFL) were reduced significantly (p0.001) in diabetic patients without retinopathy compared to control subjects. Furthermore, CNFD, CNBD and CNFL were also significantly (p0.001) reduced in diabetic patients without microalbuminuria (n=39), compared to control subjects. Greater neuropathic severity was associated with established retinopathy and microalbuminuria.

Original languageEnglish
Article numbere0123517
JournalPLoS One
Volume10
Issue number4
DOIs
Publication statusPublished - 8 Apr 2015

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retinal diseases
peripheral nervous system diseases
insulin-dependent diabetes mellitus
Confocal microscopy
Medical problems
Type 1 Diabetes Mellitus
Confocal Microscopy
Neural Conduction
Sural Nerve
Peripheral Nervous System Diseases
Photography
nerve tissue
Peroneal Nerve
Albuminuria
Diabetic Neuropathies
Albumins
Creatinine
Diabetes Complications
Vibration
Nerve Fibers

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria. / Petropoulos, Ioannis N.; Green, Patrick; Chan, Agnes W.S.; Alam, Uazman; Fadavi, Hassan; Marshall, Andrew; Asghar, Omar; Efron, Nathan; Tavakoli, Mitra; Malik, Rayaz.

In: PLoS One, Vol. 10, No. 4, e0123517, 08.04.2015.

Research output: Contribution to journalArticle

Petropoulos, IN, Green, P, Chan, AWS, Alam, U, Fadavi, H, Marshall, A, Asghar, O, Efron, N, Tavakoli, M & Malik, R 2015, 'Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria', PLoS One, vol. 10, no. 4, e0123517. https://doi.org/10.1371/journal.pone.0123517
Petropoulos, Ioannis N. ; Green, Patrick ; Chan, Agnes W.S. ; Alam, Uazman ; Fadavi, Hassan ; Marshall, Andrew ; Asghar, Omar ; Efron, Nathan ; Tavakoli, Mitra ; Malik, Rayaz. / Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria. In: PLoS One. 2015 ; Vol. 10, No. 4.
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abstract = "Objective Corneal innervation is increasingly used as a surrogate marker of human diabetic peripheral neuropathy (DPN) however its temporal relationship with the other microvascular complications of diabetes is not fully established. In this cross-sectional, observational study we aimed to assess whether neuropathy occurred in patients with type 1 diabetes, without retinopathy or microalbuminuria. Materials and Methods All participants underwent detailed assessment of peripheral neuropathy [neuropathy disability score (NDS), vibration perception threshold (VPT), peroneal motor nerve conduction velocity (PMNCV), sural sensory nerve conduction velocity (SSNCV) and in vivo corneal confocal microscopy (IVCCM)], retinopathy (digital fundus photography) and albuminuria status [albumin: creatinine ratio (ACR)]. Results 53 patients with Type 1 diabetes with (n=37) and without retinopathy (n=16) were compared to control subjects (n=27). SSNCV, corneal nerve fibre (CNFD) and branch (CNBD) density and length (CNFL) were reduced significantly (p0.001) in diabetic patients without retinopathy compared to control subjects. Furthermore, CNFD, CNBD and CNFL were also significantly (p0.001) reduced in diabetic patients without microalbuminuria (n=39), compared to control subjects. Greater neuropathic severity was associated with established retinopathy and microalbuminuria.",
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