Corneal and retinal neuronal degeneration in early stages of diabetic retinopathy

Sangeetha Srinivasan, Cirous Dehghani, Nicola Pritchard, Katie Edwards, Anthony W. Russell, Rayaz Malik, Nathan Efron

Research output: Contribution to journalArticle

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Abstract

PURPOSE. To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR). METHODS. Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), corneal nerve fiber tortuosity (CNFT), full retinal thickness, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), focal (FLV) and global loss volumes (GLV), hemoglobin A1c (HbA1c), nephropathy, neuropathy, and cardiovascular measures were examined. RESULTS. The central zone (P = 0.174), parafoveal thickness (P = 0.090), perifovea (P = 0.592), RNFL (P = 0.866), GCC (P = 0.798), and GCC GLV (P = 0.338) did not differ significantly between the groups. In comparison to the control group, those with very mild NPDR and those with mild NPDR had significantly higher focal loss in GCC volume (P = 0.036). CNFL was significantly lower in those with mild NPDR (P = 0.004) in comparison to the control group and those with no DR. The CNBD (P = 0.094) and CNFT (P = 0.458) did not differ between the groups. CONCLUSIONS. Both corneal and retinal neuronal degeneration may occur in early stages of diabetic retinopathy. Further studies are required to examine these potential markers for neuronal degeneration in the absence of clinical signs of DR.

Original languageEnglish
Pages (from-to)6365-6373
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume58
Issue number14
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Retinal Degeneration
Diabetic Retinopathy
Nerve Fibers
Ganglia
Control Groups
Queensland
Cell Size
Cornea
Retina
Hemoglobins

Keywords

  • Diabetes
  • Ganglion cell complex
  • Optical coherence tomography
  • Retinal thickness
  • Retinopathy

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Srinivasan, S., Dehghani, C., Pritchard, N., Edwards, K., Russell, A. W., Malik, R., & Efron, N. (2017). Corneal and retinal neuronal degeneration in early stages of diabetic retinopathy. Investigative Ophthalmology and Visual Science, 58(14), 6365-6373. https://doi.org/10.1167/iovs.17-22736

Corneal and retinal neuronal degeneration in early stages of diabetic retinopathy. / Srinivasan, Sangeetha; Dehghani, Cirous; Pritchard, Nicola; Edwards, Katie; Russell, Anthony W.; Malik, Rayaz; Efron, Nathan.

In: Investigative Ophthalmology and Visual Science, Vol. 58, No. 14, 01.12.2017, p. 6365-6373.

Research output: Contribution to journalArticle

Srinivasan, S, Dehghani, C, Pritchard, N, Edwards, K, Russell, AW, Malik, R & Efron, N 2017, 'Corneal and retinal neuronal degeneration in early stages of diabetic retinopathy', Investigative Ophthalmology and Visual Science, vol. 58, no. 14, pp. 6365-6373. https://doi.org/10.1167/iovs.17-22736
Srinivasan, Sangeetha ; Dehghani, Cirous ; Pritchard, Nicola ; Edwards, Katie ; Russell, Anthony W. ; Malik, Rayaz ; Efron, Nathan. / Corneal and retinal neuronal degeneration in early stages of diabetic retinopathy. In: Investigative Ophthalmology and Visual Science. 2017 ; Vol. 58, No. 14. pp. 6365-6373.
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AU - Srinivasan, Sangeetha

AU - Dehghani, Cirous

AU - Pritchard, Nicola

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AU - Russell, Anthony W.

AU - Malik, Rayaz

AU - Efron, Nathan

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N2 - PURPOSE. To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR). METHODS. Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), corneal nerve fiber tortuosity (CNFT), full retinal thickness, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), focal (FLV) and global loss volumes (GLV), hemoglobin A1c (HbA1c), nephropathy, neuropathy, and cardiovascular measures were examined. RESULTS. The central zone (P = 0.174), parafoveal thickness (P = 0.090), perifovea (P = 0.592), RNFL (P = 0.866), GCC (P = 0.798), and GCC GLV (P = 0.338) did not differ significantly between the groups. In comparison to the control group, those with very mild NPDR and those with mild NPDR had significantly higher focal loss in GCC volume (P = 0.036). CNFL was significantly lower in those with mild NPDR (P = 0.004) in comparison to the control group and those with no DR. The CNBD (P = 0.094) and CNFT (P = 0.458) did not differ between the groups. CONCLUSIONS. Both corneal and retinal neuronal degeneration may occur in early stages of diabetic retinopathy. Further studies are required to examine these potential markers for neuronal degeneration in the absence of clinical signs of DR.

AB - PURPOSE. To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR). METHODS. Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), corneal nerve fiber tortuosity (CNFT), full retinal thickness, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), focal (FLV) and global loss volumes (GLV), hemoglobin A1c (HbA1c), nephropathy, neuropathy, and cardiovascular measures were examined. RESULTS. The central zone (P = 0.174), parafoveal thickness (P = 0.090), perifovea (P = 0.592), RNFL (P = 0.866), GCC (P = 0.798), and GCC GLV (P = 0.338) did not differ significantly between the groups. In comparison to the control group, those with very mild NPDR and those with mild NPDR had significantly higher focal loss in GCC volume (P = 0.036). CNFL was significantly lower in those with mild NPDR (P = 0.004) in comparison to the control group and those with no DR. The CNBD (P = 0.094) and CNFT (P = 0.458) did not differ between the groups. CONCLUSIONS. Both corneal and retinal neuronal degeneration may occur in early stages of diabetic retinopathy. Further studies are required to examine these potential markers for neuronal degeneration in the absence of clinical signs of DR.

KW - Diabetes

KW - Ganglion cell complex

KW - Optical coherence tomography

KW - Retinal thickness

KW - Retinopathy

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