Coping with stress: Multiple ways to activate p53

Henning Horn, K. H. Vousden

Research output: Contribution to journalReview article

336 Citations (Scopus)

Abstract

Over the years, p53 has been shown to sit at the centre of an increasingly complex web of incoming stress signals and outgoing effector pathways. The number and diversity of stress signals that lead to p53 activation illustrates the breadth of p53's remit - responding to a wide variety of potentially oncogenic insults to prevent tumour development. Interestingly, different stress signals can use different and independent pathways to activate p53, and there is some evidence that different stress signals can mediate different responses. How each of the responses to p53 contributes to inhibition of malignant progression is beginning to be clarified, with the hope that identification of responses that are key to tumour suppression will allow a more focused and effective search for new therapeutic targets. In this review, we will highlight some recently identified roles for p53 in tumour suppression, and discuss some of the numerous mechanisms through which p53 can be regulated and activated.

Original languageEnglish
Pages (from-to)1306-1316
Number of pages11
JournalOncogene
Volume26
Issue number9
DOIs
Publication statusPublished - 26 Feb 2007
Externally publishedYes

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Keywords

  • Apoptosis
  • MDM2
  • p53
  • Tumour suppression
  • Ubiquitination

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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