Controlling metastatic cancer

the role of phytochemicals in cell signaling

Andrea Kapinova, Peter Kubatka, Alena Liskova, Denis Baranenko, Peter Kruzliak, Milan Matta, Dietrich Busselberg, Bibiana Malicherova, Anthony Zulli, Taeg Kyu Kwon, Eva Jezkova, Dana Blahutova, Pavol Zubor, Jan Danko

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose: Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. Results: Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. Conclusions: Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.

Original languageEnglish
JournalJournal of Cancer Research and Clinical Oncology
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Phytochemicals
Neoplasms
Neoplasm Metastasis
Chemoprevention
Cause of Death
Carcinogenesis
Clinical Trials
Health
Research

Keywords

  • Chemoprevention
  • Metastatic cancer
  • Phytochemicals
  • Signaling pathways
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Controlling metastatic cancer : the role of phytochemicals in cell signaling. / Kapinova, Andrea; Kubatka, Peter; Liskova, Alena; Baranenko, Denis; Kruzliak, Peter; Matta, Milan; Busselberg, Dietrich; Malicherova, Bibiana; Zulli, Anthony; Kwon, Taeg Kyu; Jezkova, Eva; Blahutova, Dana; Zubor, Pavol; Danko, Jan.

In: Journal of Cancer Research and Clinical Oncology, 01.01.2019.

Research output: Contribution to journalReview article

Kapinova, A, Kubatka, P, Liskova, A, Baranenko, D, Kruzliak, P, Matta, M, Busselberg, D, Malicherova, B, Zulli, A, Kwon, TK, Jezkova, E, Blahutova, D, Zubor, P & Danko, J 2019, 'Controlling metastatic cancer: the role of phytochemicals in cell signaling', Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-019-02892-5
Kapinova, Andrea ; Kubatka, Peter ; Liskova, Alena ; Baranenko, Denis ; Kruzliak, Peter ; Matta, Milan ; Busselberg, Dietrich ; Malicherova, Bibiana ; Zulli, Anthony ; Kwon, Taeg Kyu ; Jezkova, Eva ; Blahutova, Dana ; Zubor, Pavol ; Danko, Jan. / Controlling metastatic cancer : the role of phytochemicals in cell signaling. In: Journal of Cancer Research and Clinical Oncology. 2019.
@article{f302e016cdfe4beda7f971cdda4d0d9d,
title = "Controlling metastatic cancer: the role of phytochemicals in cell signaling",
abstract = "Purpose: Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90{\%}) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. Results: Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. Conclusions: Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.",
keywords = "Chemoprevention, Metastatic cancer, Phytochemicals, Signaling pathways, Therapy",
author = "Andrea Kapinova and Peter Kubatka and Alena Liskova and Denis Baranenko and Peter Kruzliak and Milan Matta and Dietrich Busselberg and Bibiana Malicherova and Anthony Zulli and Kwon, {Taeg Kyu} and Eva Jezkova and Dana Blahutova and Pavol Zubor and Jan Danko",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00432-019-02892-5",
language = "English",
journal = "Journal of Cancer Research and Clinical Oncology",
issn = "0171-5216",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Controlling metastatic cancer

T2 - the role of phytochemicals in cell signaling

AU - Kapinova, Andrea

AU - Kubatka, Peter

AU - Liskova, Alena

AU - Baranenko, Denis

AU - Kruzliak, Peter

AU - Matta, Milan

AU - Busselberg, Dietrich

AU - Malicherova, Bibiana

AU - Zulli, Anthony

AU - Kwon, Taeg Kyu

AU - Jezkova, Eva

AU - Blahutova, Dana

AU - Zubor, Pavol

AU - Danko, Jan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. Results: Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. Conclusions: Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.

AB - Purpose: Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. Results: Current research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds. Conclusions: Based on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.

KW - Chemoprevention

KW - Metastatic cancer

KW - Phytochemicals

KW - Signaling pathways

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=85064179880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064179880&partnerID=8YFLogxK

U2 - 10.1007/s00432-019-02892-5

DO - 10.1007/s00432-019-02892-5

M3 - Review article

JO - Journal of Cancer Research and Clinical Oncology

JF - Journal of Cancer Research and Clinical Oncology

SN - 0171-5216

ER -