Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index

M. Ribases, M. Gratacos, A. Badia, L. Jimenez, R. Solano, J. Vallejo, F. Fernandez-Aranda, Xavier P. Estivill

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders (ED) with complex genetic and environmental components. Genetic studies and animal models support the participation of brain-derived neurotrophic factor (BDNF) in the vulnerability to AN and BN. We investigated the genetic contribution of the BDNF-specific receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) to the susceptibility to ED. We have screened the entire NTRK2 gene in 91 patients with ED and have identified 14 single-nucleotide polymorphisms (SNPs). A population-based association study with six SNPs from the NTRK2 locus was performed in 164 ED patients and 121 controls. Significant evidence of association for markers -69C > G and IVS13 + 40G > A was detected. We also observed a strong association between the C-A-insC haplotype (-69/IVS13 + 40/2784-2785) and binge-eating/purging AN (ANP, P = 0.006; OR = 2.27), and a reduced frequency of haplotype G-A-delCI in BN patients (P = 0.034; OR = 0.6). The analysis of ED-related phenotypes revealed a clear association between NTRK2, high scores of Harm avoidance measured by the temperament and character inventory (TCI-R; P = 0.003) and minimum body mass index (minBMI; P < 0.001). Our data support a contribution of NTRK2 to the genetic susceptibility of ED, mainly ANP, and ED-related phenotypic traits, such as Harm avoidance and minBMI.

Original languageEnglish
Pages (from-to)851-860
Number of pages10
JournalMolecular Psychiatry
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 2005
Externally publishedYes

Fingerprint

trkB Receptor
Anorexia Nervosa
Genetic Predisposition to Disease
Body Mass Index
Bulimia Nervosa
Haplotypes
Single Nucleotide Polymorphism
Bulimia
Temperament
Genetic Models
Brain-Derived Neurotrophic Factor
Atrial Natriuretic Factor
Feeding and Eating Disorders
Animal Models
Phenotype
Equipment and Supplies

Keywords

  • Anorexia
  • BDNF
  • Bulimia
  • Eating disorders
  • Harm avoidance
  • NTRK2

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index. / Ribases, M.; Gratacos, M.; Badia, A.; Jimenez, L.; Solano, R.; Vallejo, J.; Fernandez-Aranda, F.; Estivill, Xavier P.

In: Molecular Psychiatry, Vol. 10, No. 9, 09.2005, p. 851-860.

Research output: Contribution to journalArticle

Ribases, M, Gratacos, M, Badia, A, Jimenez, L, Solano, R, Vallejo, J, Fernandez-Aranda, F & Estivill, XP 2005, 'Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index', Molecular Psychiatry, vol. 10, no. 9, pp. 851-860. https://doi.org/10.1038/sj.mp.4001670
Ribases, M. ; Gratacos, M. ; Badia, A. ; Jimenez, L. ; Solano, R. ; Vallejo, J. ; Fernandez-Aranda, F. ; Estivill, Xavier P. / Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index. In: Molecular Psychiatry. 2005 ; Vol. 10, No. 9. pp. 851-860.
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