Continuum of overlapping clones spanning the entire human chromosome 21q

Ilya Chumakov, Philippe Rigault, Sophie Guillou, Pierre Ougen, Alain Billaut, Ghislaine Guasconi, Patricia Gervy, Isabelle LeGall, Pascal Soularue, Laurent Grinas, Lydie Bougueleret, Christine Bellanné-Chantelot, Bruno Lacroix, Emmanuel Barillot, Philippe Gesnouin, Stuart Pook, Guy Vaysseix, Gerard Frelat, Annette Schmitz, Jean Luc SambucyAssumpcio Bosch, Xavier P. Estivill, Jean Weissenbach, Alain Vignal, Harold Riethman, David Cox, David Patterson, Kathleen Gardiner, Masahira Hattori, Yoshiyuki Sakaki, Hitoshi Ichikawa, Misao Ohki, Denis Le Paslier, Roland Heilig, Stylianos Antonarakis, Daniel Cohen

Research output: Contribution to journalArticle

425 Citations (Scopus)

Abstract

A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and ends with subtelomeric loci of 21q. The resulting order of sequence-tagged sites is consistent with other physical and genetic mapping data. This set of overlapping clones will promote our knowledge of the structure of this chromosome and the function of its genes.

Original languageEnglish
Pages (from-to)380-387
Number of pages8
JournalNature
Volume359
Issue number6394
Publication statusPublished - 1992
Externally publishedYes

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Sequence Tagged Sites
Yeast Artificial Chromosomes
Human Chromosomes
Human Artificial Chromosomes
Physical Chromosome Mapping
Clone Cells
Chromosome Structures
Polymerase Chain Reaction
Genes

ASJC Scopus subject areas

  • General

Cite this

Chumakov, I., Rigault, P., Guillou, S., Ougen, P., Billaut, A., Guasconi, G., ... Cohen, D. (1992). Continuum of overlapping clones spanning the entire human chromosome 21q. Nature, 359(6394), 380-387.

Continuum of overlapping clones spanning the entire human chromosome 21q. / Chumakov, Ilya; Rigault, Philippe; Guillou, Sophie; Ougen, Pierre; Billaut, Alain; Guasconi, Ghislaine; Gervy, Patricia; LeGall, Isabelle; Soularue, Pascal; Grinas, Laurent; Bougueleret, Lydie; Bellanné-Chantelot, Christine; Lacroix, Bruno; Barillot, Emmanuel; Gesnouin, Philippe; Pook, Stuart; Vaysseix, Guy; Frelat, Gerard; Schmitz, Annette; Sambucy, Jean Luc; Bosch, Assumpcio; Estivill, Xavier P.; Weissenbach, Jean; Vignal, Alain; Riethman, Harold; Cox, David; Patterson, David; Gardiner, Kathleen; Hattori, Masahira; Sakaki, Yoshiyuki; Ichikawa, Hitoshi; Ohki, Misao; Paslier, Denis Le; Heilig, Roland; Antonarakis, Stylianos; Cohen, Daniel.

In: Nature, Vol. 359, No. 6394, 1992, p. 380-387.

Research output: Contribution to journalArticle

Chumakov, I, Rigault, P, Guillou, S, Ougen, P, Billaut, A, Guasconi, G, Gervy, P, LeGall, I, Soularue, P, Grinas, L, Bougueleret, L, Bellanné-Chantelot, C, Lacroix, B, Barillot, E, Gesnouin, P, Pook, S, Vaysseix, G, Frelat, G, Schmitz, A, Sambucy, JL, Bosch, A, Estivill, XP, Weissenbach, J, Vignal, A, Riethman, H, Cox, D, Patterson, D, Gardiner, K, Hattori, M, Sakaki, Y, Ichikawa, H, Ohki, M, Paslier, DL, Heilig, R, Antonarakis, S & Cohen, D 1992, 'Continuum of overlapping clones spanning the entire human chromosome 21q', Nature, vol. 359, no. 6394, pp. 380-387.
Chumakov I, Rigault P, Guillou S, Ougen P, Billaut A, Guasconi G et al. Continuum of overlapping clones spanning the entire human chromosome 21q. Nature. 1992;359(6394):380-387.
Chumakov, Ilya ; Rigault, Philippe ; Guillou, Sophie ; Ougen, Pierre ; Billaut, Alain ; Guasconi, Ghislaine ; Gervy, Patricia ; LeGall, Isabelle ; Soularue, Pascal ; Grinas, Laurent ; Bougueleret, Lydie ; Bellanné-Chantelot, Christine ; Lacroix, Bruno ; Barillot, Emmanuel ; Gesnouin, Philippe ; Pook, Stuart ; Vaysseix, Guy ; Frelat, Gerard ; Schmitz, Annette ; Sambucy, Jean Luc ; Bosch, Assumpcio ; Estivill, Xavier P. ; Weissenbach, Jean ; Vignal, Alain ; Riethman, Harold ; Cox, David ; Patterson, David ; Gardiner, Kathleen ; Hattori, Masahira ; Sakaki, Yoshiyuki ; Ichikawa, Hitoshi ; Ohki, Misao ; Paslier, Denis Le ; Heilig, Roland ; Antonarakis, Stylianos ; Cohen, Daniel. / Continuum of overlapping clones spanning the entire human chromosome 21q. In: Nature. 1992 ; Vol. 359, No. 6394. pp. 380-387.
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AU - Rigault, Philippe

AU - Guillou, Sophie

AU - Ougen, Pierre

AU - Billaut, Alain

AU - Guasconi, Ghislaine

AU - Gervy, Patricia

AU - LeGall, Isabelle

AU - Soularue, Pascal

AU - Grinas, Laurent

AU - Bougueleret, Lydie

AU - Bellanné-Chantelot, Christine

AU - Lacroix, Bruno

AU - Barillot, Emmanuel

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AU - Pook, Stuart

AU - Vaysseix, Guy

AU - Frelat, Gerard

AU - Schmitz, Annette

AU - Sambucy, Jean Luc

AU - Bosch, Assumpcio

AU - Estivill, Xavier P.

AU - Weissenbach, Jean

AU - Vignal, Alain

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AU - Cox, David

AU - Patterson, David

AU - Gardiner, Kathleen

AU - Hattori, Masahira

AU - Sakaki, Yoshiyuki

AU - Ichikawa, Hitoshi

AU - Ohki, Misao

AU - Paslier, Denis Le

AU - Heilig, Roland

AU - Antonarakis, Stylianos

AU - Cohen, Daniel

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