Consensus nomenclature for CD8+ T cell phenotypes in cancer

Lionel Apetoh, Mark J. Smyth, Charles G. Drake, Jean Pierre Abastado, Ron N. Apte, Maha Ayyoub, Jean Yves Blay, Marc Bonneville, Lisa H. Butterfield, Anne Caignard, Chiara Castelli, Federica Cavallo, Esteban Celis, Lieping Chen, Mario P. Colombo, Begoña Comin-Anduix, Georges Coukos, Madhav V. Dhodapkar, Glenn Dranoff, Ian H. Frazer & 39 others Wolf Hervé Fridman, Dmitry I. Gabrilovich, Eli Gilboa, Sacha Gnjatic, Dirk Jäger, Pawel Kalinski, Howard L. Kaufman, Rolf Kiessling, John Kirkwood, Alexander Knuth, Roland Liblau, Michael T. Lotze, Enrico Lugli, Francesco Marincola, Ignacio Melero, Cornelis J. Melief, Thorsten R. Mempel, Elizabeth A. Mittendorf, Kunle Odun, Willem W. Overwijk, Anna Karolina Palucka, Giorgio Parmiani, Antoni Ribas, Pedro Romero, Robert D. Schreiber, Gerold Schuler, Pramod K. Srivastava, Eric Tartour, Danila Valmori, Sjoerd H. van der Burg, Pierre van der Bruggen, Benoît J. van den Eynde, Ena Wang, Weiping Zou, Theresa L. Whiteside, Daniel E. Speiser, Drew M. Pardoll, Nicholas P. Restifo, Ana C. Anderson

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T cells in cancer calls for a more precise definition of the CD8+ T cell immune phenotypes in cancer and the abandonment of the generic terms “pro-tumor” and “antitumor.” Based on recent studies investigating the functions of CD8+ T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8+T cells in cancer.

Original languageEnglish
JournalOncoImmunology
Volume4
Issue number4
DOIs
Publication statusPublished - 2015

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Terminology
T-Lymphocytes
Phenotype
Neoplasms
Tumor Microenvironment
Immunity
Guidelines
Cytokines

Keywords

  • Anergy
  • Anticancer immunity
  • CD8 T cells
  • Cytotoxicity
  • Effector
  • Exhaustion
  • IFNγ
  • Senescence
  • Stemness

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

Cite this

Apetoh, L., Smyth, M. J., Drake, C. G., Abastado, J. P., Apte, R. N., Ayyoub, M., ... Anderson, A. C. (2015). Consensus nomenclature for CD8+ T cell phenotypes in cancer. OncoImmunology, 4(4). https://doi.org/10.1080/2162402X.2014.998538

Consensus nomenclature for CD8+ T cell phenotypes in cancer. / Apetoh, Lionel; Smyth, Mark J.; Drake, Charles G.; Abastado, Jean Pierre; Apte, Ron N.; Ayyoub, Maha; Blay, Jean Yves; Bonneville, Marc; Butterfield, Lisa H.; Caignard, Anne; Castelli, Chiara; Cavallo, Federica; Celis, Esteban; Chen, Lieping; Colombo, Mario P.; Comin-Anduix, Begoña; Coukos, Georges; Dhodapkar, Madhav V.; Dranoff, Glenn; Frazer, Ian H.; Fridman, Wolf Hervé; Gabrilovich, Dmitry I.; Gilboa, Eli; Gnjatic, Sacha; Jäger, Dirk; Kalinski, Pawel; Kaufman, Howard L.; Kiessling, Rolf; Kirkwood, John; Knuth, Alexander; Liblau, Roland; Lotze, Michael T.; Lugli, Enrico; Marincola, Francesco; Melero, Ignacio; Melief, Cornelis J.; Mempel, Thorsten R.; Mittendorf, Elizabeth A.; Odun, Kunle; Overwijk, Willem W.; Palucka, Anna Karolina; Parmiani, Giorgio; Ribas, Antoni; Romero, Pedro; Schreiber, Robert D.; Schuler, Gerold; Srivastava, Pramod K.; Tartour, Eric; Valmori, Danila; van der Burg, Sjoerd H.; van der Bruggen, Pierre; van den Eynde, Benoît J.; Wang, Ena; Zou, Weiping; Whiteside, Theresa L.; Speiser, Daniel E.; Pardoll, Drew M.; Restifo, Nicholas P.; Anderson, Ana C.

In: OncoImmunology, Vol. 4, No. 4, 2015.

Research output: Contribution to journalArticle

Apetoh, L, Smyth, MJ, Drake, CG, Abastado, JP, Apte, RN, Ayyoub, M, Blay, JY, Bonneville, M, Butterfield, LH, Caignard, A, Castelli, C, Cavallo, F, Celis, E, Chen, L, Colombo, MP, Comin-Anduix, B, Coukos, G, Dhodapkar, MV, Dranoff, G, Frazer, IH, Fridman, WH, Gabrilovich, DI, Gilboa, E, Gnjatic, S, Jäger, D, Kalinski, P, Kaufman, HL, Kiessling, R, Kirkwood, J, Knuth, A, Liblau, R, Lotze, MT, Lugli, E, Marincola, F, Melero, I, Melief, CJ, Mempel, TR, Mittendorf, EA, Odun, K, Overwijk, WW, Palucka, AK, Parmiani, G, Ribas, A, Romero, P, Schreiber, RD, Schuler, G, Srivastava, PK, Tartour, E, Valmori, D, van der Burg, SH, van der Bruggen, P, van den Eynde, BJ, Wang, E, Zou, W, Whiteside, TL, Speiser, DE, Pardoll, DM, Restifo, NP & Anderson, AC 2015, 'Consensus nomenclature for CD8+ T cell phenotypes in cancer', OncoImmunology, vol. 4, no. 4. https://doi.org/10.1080/2162402X.2014.998538
Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M et al. Consensus nomenclature for CD8+ T cell phenotypes in cancer. OncoImmunology. 2015;4(4). https://doi.org/10.1080/2162402X.2014.998538
Apetoh, Lionel ; Smyth, Mark J. ; Drake, Charles G. ; Abastado, Jean Pierre ; Apte, Ron N. ; Ayyoub, Maha ; Blay, Jean Yves ; Bonneville, Marc ; Butterfield, Lisa H. ; Caignard, Anne ; Castelli, Chiara ; Cavallo, Federica ; Celis, Esteban ; Chen, Lieping ; Colombo, Mario P. ; Comin-Anduix, Begoña ; Coukos, Georges ; Dhodapkar, Madhav V. ; Dranoff, Glenn ; Frazer, Ian H. ; Fridman, Wolf Hervé ; Gabrilovich, Dmitry I. ; Gilboa, Eli ; Gnjatic, Sacha ; Jäger, Dirk ; Kalinski, Pawel ; Kaufman, Howard L. ; Kiessling, Rolf ; Kirkwood, John ; Knuth, Alexander ; Liblau, Roland ; Lotze, Michael T. ; Lugli, Enrico ; Marincola, Francesco ; Melero, Ignacio ; Melief, Cornelis J. ; Mempel, Thorsten R. ; Mittendorf, Elizabeth A. ; Odun, Kunle ; Overwijk, Willem W. ; Palucka, Anna Karolina ; Parmiani, Giorgio ; Ribas, Antoni ; Romero, Pedro ; Schreiber, Robert D. ; Schuler, Gerold ; Srivastava, Pramod K. ; Tartour, Eric ; Valmori, Danila ; van der Burg, Sjoerd H. ; van der Bruggen, Pierre ; van den Eynde, Benoît J. ; Wang, Ena ; Zou, Weiping ; Whiteside, Theresa L. ; Speiser, Daniel E. ; Pardoll, Drew M. ; Restifo, Nicholas P. ; Anderson, Ana C. / Consensus nomenclature for CD8+ T cell phenotypes in cancer. In: OncoImmunology. 2015 ; Vol. 4, No. 4.
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AU - Smyth, Mark J.

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AU - Abastado, Jean Pierre

AU - Apte, Ron N.

AU - Ayyoub, Maha

AU - Blay, Jean Yves

AU - Bonneville, Marc

AU - Butterfield, Lisa H.

AU - Caignard, Anne

AU - Castelli, Chiara

AU - Cavallo, Federica

AU - Celis, Esteban

AU - Chen, Lieping

AU - Colombo, Mario P.

AU - Comin-Anduix, Begoña

AU - Coukos, Georges

AU - Dhodapkar, Madhav V.

AU - Dranoff, Glenn

AU - Frazer, Ian H.

AU - Fridman, Wolf Hervé

AU - Gabrilovich, Dmitry I.

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AU - Lotze, Michael T.

AU - Lugli, Enrico

AU - Marincola, Francesco

AU - Melero, Ignacio

AU - Melief, Cornelis J.

AU - Mempel, Thorsten R.

AU - Mittendorf, Elizabeth A.

AU - Odun, Kunle

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AU - Palucka, Anna Karolina

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AU - Whiteside, Theresa L.

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KW - Anticancer immunity

KW - CD8 T cells

KW - Cytotoxicity

KW - Effector

KW - Exhaustion

KW - IFNγ

KW - Senescence

KW - Stemness

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