Conformational analysis of peptides derived from the BRI gene

Victor Lelyveld, Omar Ali El-Agnaf, Giuliano Siligardi, Rohana Hussain, Parvez I. Haris, Maria Lee, Brian Austen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The 34-residue peptides (ABri and ADan) derived from the 3′ end of the gene BRI which is mutated in British and Danish families with dementia, have been synthesized, with and without the predicted intramolecular disulphides. CD measurements show that the oxidised and reduced forms have tendencies to adopt β-structure at neutral pH with prolonged time of incubation. The shift to β-structure is accompanied by oligomer formation. The neurotoxic properties of these oligomers in vitro may explain the cognitive decline seen in the patients. Structural analyses will be useful in the design of therapeutic drugs.

Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalSpectroscopy
Volume15
Issue number3-4
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Oligomers
Genes
Peptides
Disulfides
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Spectroscopy

Cite this

Lelyveld, V., Ali El-Agnaf, O., Siligardi, G., Hussain, R., Haris, P. I., Lee, M., & Austen, B. (2001). Conformational analysis of peptides derived from the BRI gene. Spectroscopy, 15(3-4), 129-139. https://doi.org/10.1155/2001/246251

Conformational analysis of peptides derived from the BRI gene. / Lelyveld, Victor; Ali El-Agnaf, Omar; Siligardi, Giuliano; Hussain, Rohana; Haris, Parvez I.; Lee, Maria; Austen, Brian.

In: Spectroscopy, Vol. 15, No. 3-4, 2001, p. 129-139.

Research output: Contribution to journalArticle

Lelyveld, V, Ali El-Agnaf, O, Siligardi, G, Hussain, R, Haris, PI, Lee, M & Austen, B 2001, 'Conformational analysis of peptides derived from the BRI gene', Spectroscopy, vol. 15, no. 3-4, pp. 129-139. https://doi.org/10.1155/2001/246251
Lelyveld V, Ali El-Agnaf O, Siligardi G, Hussain R, Haris PI, Lee M et al. Conformational analysis of peptides derived from the BRI gene. Spectroscopy. 2001;15(3-4):129-139. https://doi.org/10.1155/2001/246251
Lelyveld, Victor ; Ali El-Agnaf, Omar ; Siligardi, Giuliano ; Hussain, Rohana ; Haris, Parvez I. ; Lee, Maria ; Austen, Brian. / Conformational analysis of peptides derived from the BRI gene. In: Spectroscopy. 2001 ; Vol. 15, No. 3-4. pp. 129-139.
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