Confirmation of the novel association at the BTNL2 locus with ulcerative colitis

S. Pathan, R. E. Gowdy, R. Cooney, J. B. Beckly, L. Hancock, C. Guo, J. C. Barrett, A. Morris, D. P. Jewell

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Linkage in families and association in population case-control investigations have clearly shown that genes within the major histocompatibility complex region on chromosome 6p are relevant to the susceptibility and pathogenesis of ulcerative colitis (UC) and Crohn's disease. However, identifying the causative variants by fine mapping has not been conclusive. In this study using 58 single nucleotide polymorphisms (SNPs) with 616 UC cases, there was significant association with SNP rs2294881 of the (butyrophilin-like 2) BTNL2 gene with odds ratio (OR) = 2.80, confidence interval (CI) = 1.62-4.84 and P = 5.69 × 10-4 (PBonferroni = 3.3 × 10-2) and replication of SNP rs9268480. The missense SNP rs2076523 (K196E) showed novel association with a subset of UC cases with colectomy (n = 126), OR = 0.25, CI = 0.11-0.58 and P = 4.42 × 10-4 (P Bonferroni = 2.56 × 10-2). These three associated variants within the BTNL2 gene were neither in linkage disequilibrium with each other nor correlated with the SNPs tagging the human leukocyte antigen (HLA)-DRB1*1502 and HLA-DRB1*0301 alleles.

Original languageEnglish
Pages (from-to)322-329
Number of pages8
JournalTissue Antigens
Volume74
Issue number4
DOIs
Publication statusPublished - Oct 2009
Externally publishedYes

Fingerprint

Ulcerative Colitis
Single Nucleotide Polymorphism
HLA Antigens
Odds Ratio
Confidence Intervals
Genes
Population Control
Colectomy
Linkage Disequilibrium
Major Histocompatibility Complex
Crohn Disease
Chromosomes
Alleles

Keywords

  • Butyrophilin-like 2
  • Crohn's disease
  • Human leukocyte antigen
  • Inflammatory bowel disease
  • Major histocompatibility complex
  • Ulcerative colitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics

Cite this

Pathan, S., Gowdy, R. E., Cooney, R., Beckly, J. B., Hancock, L., Guo, C., ... Jewell, D. P. (2009). Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. Tissue Antigens, 74(4), 322-329. https://doi.org/10.1111/j.1399-0039.2009.01314.x

Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. / Pathan, S.; Gowdy, R. E.; Cooney, R.; Beckly, J. B.; Hancock, L.; Guo, C.; Barrett, J. C.; Morris, A.; Jewell, D. P.

In: Tissue Antigens, Vol. 74, No. 4, 10.2009, p. 322-329.

Research output: Contribution to journalArticle

Pathan, S, Gowdy, RE, Cooney, R, Beckly, JB, Hancock, L, Guo, C, Barrett, JC, Morris, A & Jewell, DP 2009, 'Confirmation of the novel association at the BTNL2 locus with ulcerative colitis', Tissue Antigens, vol. 74, no. 4, pp. 322-329. https://doi.org/10.1111/j.1399-0039.2009.01314.x
Pathan, S. ; Gowdy, R. E. ; Cooney, R. ; Beckly, J. B. ; Hancock, L. ; Guo, C. ; Barrett, J. C. ; Morris, A. ; Jewell, D. P. / Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. In: Tissue Antigens. 2009 ; Vol. 74, No. 4. pp. 322-329.
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