Compression of functional space in HLA-A sequence diversity

Bing Zhao, Adrian Eak H Png, Ee Chee Ren, Prasanna Kolatkar, Venkatarajan Subramaniam Mathura, Meena Kishore Sakharkar, Pandjassarame Kangueane

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) is highly polymorphic and more than 1500 human MHC alleles are known to date. These alleles do not bind to a given peptide with identical affinity. Although MHC alleles are functionally related, it is difficult to quantify the functional variation between them. Three-dimensional structures of known MHC-peptide (MHCp) complexes suggest that specific peptide residues bind selectively to functional pockets in the binding groove. From a set of known MHCp structures we identified 21 critical polymorphic functional residue positions (CPFRP) that significantly reduced functional pocket variability to just 189 among 212 HLA-A alleles. Interestingly 101 HLA-A alleles clustered into 29 clusters such that the six functional pockets formed by the CPFRPs are identical within the cluster.

Original languageEnglish
Pages (from-to)718-728
Number of pages11
JournalHuman Immunology
Volume64
Issue number7
DOIs
Publication statusPublished - 1 Jul 2003
Externally publishedYes

Fingerprint

HLA-A Antigens
Major Histocompatibility Complex
Alleles
Peptides

Keywords

  • Functional pocket
  • MHC
  • Peptide binding

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Zhao, B., Png, A. E. H., Ren, E. C., Kolatkar, P., Mathura, V. S., Sakharkar, M. K., & Kangueane, P. (2003). Compression of functional space in HLA-A sequence diversity. Human Immunology, 64(7), 718-728. https://doi.org/10.1016/S0198-8859(03)00078-8

Compression of functional space in HLA-A sequence diversity. / Zhao, Bing; Png, Adrian Eak H; Ren, Ee Chee; Kolatkar, Prasanna; Mathura, Venkatarajan Subramaniam; Sakharkar, Meena Kishore; Kangueane, Pandjassarame.

In: Human Immunology, Vol. 64, No. 7, 01.07.2003, p. 718-728.

Research output: Contribution to journalArticle

Zhao, B, Png, AEH, Ren, EC, Kolatkar, P, Mathura, VS, Sakharkar, MK & Kangueane, P 2003, 'Compression of functional space in HLA-A sequence diversity', Human Immunology, vol. 64, no. 7, pp. 718-728. https://doi.org/10.1016/S0198-8859(03)00078-8
Zhao, Bing ; Png, Adrian Eak H ; Ren, Ee Chee ; Kolatkar, Prasanna ; Mathura, Venkatarajan Subramaniam ; Sakharkar, Meena Kishore ; Kangueane, Pandjassarame. / Compression of functional space in HLA-A sequence diversity. In: Human Immunology. 2003 ; Vol. 64, No. 7. pp. 718-728.
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