Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes

Rekha Seshadri, Garry S A Myers, Hervé Tettelin, Jonathan A. Eisen, John F. Heidelberg, Robert J. Dodson, Tanja M. Davidsen, Robert T. DeBoy, Derrick E. Fouts, Dan H. Haft, Jeremy Selengut, Qinghu Ren, Lauren M. Brinkac, Ramana Madupu, Jamie Kolonay, Scott A. Durkin, Sean C. Daugherty, Jyoti Shetty, Alla Shvartsbeyn, Elizabeth Gebregeorgis & 19 others Keita Geer, Getahun Tsegaye, Joel Malek, Bola Ayodeji, Sofiya Shatsman, Michael P. McLeod, David Šmajs, Jerrilyn K. Howell, Sangita Pal, Anita Amin, Pankaj Vashisth, Thomas Z. McNeill, Qin Xiang, Erica Sodergren, Ernesto Baca, George M. Weinstock, Steven J. Norris, Claire M. Fraser, Ian T. Paulsen

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome reduction, lineage-specific expansions, and horizontal gene transfer. Genes lost due to reductive evolution appear to be largely involved in metabolism and transport, whereas some of the genes that have arisen due to lineage-specific expansions are implicated in various pathogenic interactions, and genes acquired via horizontal gene transfer are largely phage-related or of unknown function.

Original languageEnglish
Pages (from-to)5646-5651
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number15
DOIs
Publication statusPublished - 13 Apr 2004
Externally publishedYes

Fingerprint

Treponema denticola
Spirochaetales
Genome
Horizontal Gene Transfer
Genes
Treponema pallidum
Genome Size
Dental Plaque
Periodontal Diseases
Syphilis
Bacteriophages
Life Style

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Seshadri, R., Myers, G. S. A., Tettelin, H., Eisen, J. A., Heidelberg, J. F., Dodson, R. J., ... Paulsen, I. T. (2004). Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proceedings of the National Academy of Sciences of the United States of America, 101(15), 5646-5651. https://doi.org/10.1073/pnas.0307639101

Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. / Seshadri, Rekha; Myers, Garry S A; Tettelin, Hervé; Eisen, Jonathan A.; Heidelberg, John F.; Dodson, Robert J.; Davidsen, Tanja M.; DeBoy, Robert T.; Fouts, Derrick E.; Haft, Dan H.; Selengut, Jeremy; Ren, Qinghu; Brinkac, Lauren M.; Madupu, Ramana; Kolonay, Jamie; Durkin, Scott A.; Daugherty, Sean C.; Shetty, Jyoti; Shvartsbeyn, Alla; Gebregeorgis, Elizabeth; Geer, Keita; Tsegaye, Getahun; Malek, Joel; Ayodeji, Bola; Shatsman, Sofiya; McLeod, Michael P.; Šmajs, David; Howell, Jerrilyn K.; Pal, Sangita; Amin, Anita; Vashisth, Pankaj; McNeill, Thomas Z.; Xiang, Qin; Sodergren, Erica; Baca, Ernesto; Weinstock, George M.; Norris, Steven J.; Fraser, Claire M.; Paulsen, Ian T.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 15, 13.04.2004, p. 5646-5651.

Research output: Contribution to journalArticle

Seshadri, R, Myers, GSA, Tettelin, H, Eisen, JA, Heidelberg, JF, Dodson, RJ, Davidsen, TM, DeBoy, RT, Fouts, DE, Haft, DH, Selengut, J, Ren, Q, Brinkac, LM, Madupu, R, Kolonay, J, Durkin, SA, Daugherty, SC, Shetty, J, Shvartsbeyn, A, Gebregeorgis, E, Geer, K, Tsegaye, G, Malek, J, Ayodeji, B, Shatsman, S, McLeod, MP, Šmajs, D, Howell, JK, Pal, S, Amin, A, Vashisth, P, McNeill, TZ, Xiang, Q, Sodergren, E, Baca, E, Weinstock, GM, Norris, SJ, Fraser, CM & Paulsen, IT 2004, 'Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes', Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 15, pp. 5646-5651. https://doi.org/10.1073/pnas.0307639101
Seshadri, Rekha ; Myers, Garry S A ; Tettelin, Hervé ; Eisen, Jonathan A. ; Heidelberg, John F. ; Dodson, Robert J. ; Davidsen, Tanja M. ; DeBoy, Robert T. ; Fouts, Derrick E. ; Haft, Dan H. ; Selengut, Jeremy ; Ren, Qinghu ; Brinkac, Lauren M. ; Madupu, Ramana ; Kolonay, Jamie ; Durkin, Scott A. ; Daugherty, Sean C. ; Shetty, Jyoti ; Shvartsbeyn, Alla ; Gebregeorgis, Elizabeth ; Geer, Keita ; Tsegaye, Getahun ; Malek, Joel ; Ayodeji, Bola ; Shatsman, Sofiya ; McLeod, Michael P. ; Šmajs, David ; Howell, Jerrilyn K. ; Pal, Sangita ; Amin, Anita ; Vashisth, Pankaj ; McNeill, Thomas Z. ; Xiang, Qin ; Sodergren, Erica ; Baca, Ernesto ; Weinstock, George M. ; Norris, Steven J. ; Fraser, Claire M. ; Paulsen, Ian T. / Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. In: Proceedings of the National Academy of Sciences of the United States of America. 2004 ; Vol. 101, No. 15. pp. 5646-5651.
@article{3d469a3e8fe34d0dbc36a6a35fcab01b,
title = "Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes",
abstract = "We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome reduction, lineage-specific expansions, and horizontal gene transfer. Genes lost due to reductive evolution appear to be largely involved in metabolism and transport, whereas some of the genes that have arisen due to lineage-specific expansions are implicated in various pathogenic interactions, and genes acquired via horizontal gene transfer are largely phage-related or of unknown function.",
author = "Rekha Seshadri and Myers, {Garry S A} and Herv{\'e} Tettelin and Eisen, {Jonathan A.} and Heidelberg, {John F.} and Dodson, {Robert J.} and Davidsen, {Tanja M.} and DeBoy, {Robert T.} and Fouts, {Derrick E.} and Haft, {Dan H.} and Jeremy Selengut and Qinghu Ren and Brinkac, {Lauren M.} and Ramana Madupu and Jamie Kolonay and Durkin, {Scott A.} and Daugherty, {Sean C.} and Jyoti Shetty and Alla Shvartsbeyn and Elizabeth Gebregeorgis and Keita Geer and Getahun Tsegaye and Joel Malek and Bola Ayodeji and Sofiya Shatsman and McLeod, {Michael P.} and David Šmajs and Howell, {Jerrilyn K.} and Sangita Pal and Anita Amin and Pankaj Vashisth and McNeill, {Thomas Z.} and Qin Xiang and Erica Sodergren and Ernesto Baca and Weinstock, {George M.} and Norris, {Steven J.} and Fraser, {Claire M.} and Paulsen, {Ian T.}",
year = "2004",
month = "4",
day = "13",
doi = "10.1073/pnas.0307639101",
language = "English",
volume = "101",
pages = "5646--5651",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "15",

}

TY - JOUR

T1 - Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes

AU - Seshadri, Rekha

AU - Myers, Garry S A

AU - Tettelin, Hervé

AU - Eisen, Jonathan A.

AU - Heidelberg, John F.

AU - Dodson, Robert J.

AU - Davidsen, Tanja M.

AU - DeBoy, Robert T.

AU - Fouts, Derrick E.

AU - Haft, Dan H.

AU - Selengut, Jeremy

AU - Ren, Qinghu

AU - Brinkac, Lauren M.

AU - Madupu, Ramana

AU - Kolonay, Jamie

AU - Durkin, Scott A.

AU - Daugherty, Sean C.

AU - Shetty, Jyoti

AU - Shvartsbeyn, Alla

AU - Gebregeorgis, Elizabeth

AU - Geer, Keita

AU - Tsegaye, Getahun

AU - Malek, Joel

AU - Ayodeji, Bola

AU - Shatsman, Sofiya

AU - McLeod, Michael P.

AU - Šmajs, David

AU - Howell, Jerrilyn K.

AU - Pal, Sangita

AU - Amin, Anita

AU - Vashisth, Pankaj

AU - McNeill, Thomas Z.

AU - Xiang, Qin

AU - Sodergren, Erica

AU - Baca, Ernesto

AU - Weinstock, George M.

AU - Norris, Steven J.

AU - Fraser, Claire M.

AU - Paulsen, Ian T.

PY - 2004/4/13

Y1 - 2004/4/13

N2 - We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome reduction, lineage-specific expansions, and horizontal gene transfer. Genes lost due to reductive evolution appear to be largely involved in metabolism and transport, whereas some of the genes that have arisen due to lineage-specific expansions are implicated in various pathogenic interactions, and genes acquired via horizontal gene transfer are largely phage-related or of unknown function.

AB - We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributable to a combination of three phenomena: genome reduction, lineage-specific expansions, and horizontal gene transfer. Genes lost due to reductive evolution appear to be largely involved in metabolism and transport, whereas some of the genes that have arisen due to lineage-specific expansions are implicated in various pathogenic interactions, and genes acquired via horizontal gene transfer are largely phage-related or of unknown function.

UR - http://www.scopus.com/inward/record.url?scp=11144358038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144358038&partnerID=8YFLogxK

U2 - 10.1073/pnas.0307639101

DO - 10.1073/pnas.0307639101

M3 - Article

VL - 101

SP - 5646

EP - 5651

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 15

ER -