Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in hiv-tuberculosis patients

Basirudeen S. Kabeer, Rajasekaran Sikhamani, Alamelu Raja

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Interferon gamma (IFNγ)-based in-vitro assays have suboptimal sensitivity, especially in immunocompromised individuals, which emphasizes the need for alternative markers for tuberculosis (TB) diagnosis. We compared TB antigens-specific IFNγ and IFNγ-inducible protein-10 levels in culture of whole blood samples from HIV-TB patients. We report that IFNγ-inducible protein-10 detects a greater number of HIV-TB cases than IFNγ and suggest that IFNγ-inducible protein-10 may be a better alternative marker for latent TB infection diagnosis among immunocompromised individuals.

Original languageEnglish
Pages (from-to)323-325
Number of pages3
JournalAIDS
Volume24
Issue number2
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Fingerprint

Chemokine CXCL10
Interferon-gamma
Tuberculosis
HIV
Latent Tuberculosis
Antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in hiv-tuberculosis patients. / Kabeer, Basirudeen S.; Sikhamani, Rajasekaran; Raja, Alamelu.

In: AIDS, Vol. 24, No. 2, 01.2010, p. 323-325.

Research output: Contribution to journalArticle

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